2024
Disturbed flow in the juxta-anastomotic area of an arteriovenous fistula correlates with endothelial loss, acute thrombus formation, and neointimal hyperplasia
Bai H, Varsanik M, Thaxton C, Ohashi Y, Gonzalez L, Zhang W, Aoyagi Y, Kano M, Yatsula B, Li Z, Pocivavsek L, Dardik A. Disturbed flow in the juxta-anastomotic area of an arteriovenous fistula correlates with endothelial loss, acute thrombus formation, and neointimal hyperplasia. AJP Heart And Circulatory Physiology 2024, 326: h1446-h1461. PMID: 38578237, DOI: 10.1152/ajpheart.00054.2024.Peer-Reviewed Original ResearchConceptsEndothelial cell lossOutflow veinChronic kidney diseaseJuxta-anastomotic areaMouse AVF modelNeointimal hyperplasiaThrombus formationAcute thrombus formationCell lossHuman AVF maturationGene OntologyAVF maturationAVF patencyEarly thrombus formationArteriovenous fistulaC57BL/6 miceClinical failureWistar ratsEndothelial lossKidney diseaseImmune responseEndothelial cellsHyperplasiaMiceAVF
2021
Roles of MicroRNAs in Peripheral Artery In-Stent Restenosis after Endovascular Treatment
Wang M, Zhang W, Zhang L, Wang L, Li J, Shu C, Li X. Roles of MicroRNAs in Peripheral Artery In-Stent Restenosis after Endovascular Treatment. BioMed Research International 2021, 2021: 9935671. PMID: 34368362, PMCID: PMC8337102, DOI: 10.1155/2021/9935671.Peer-Reviewed Original ResearchConceptsPercutaneous transluminal angioplastyEndovascular repairStent restenosisPeripheral arterial diseaseNovel therapeutic targetPotential therapeutic strategyMajor pathological processesTransluminal angioplastyArterial diseaseEndovascular treatmentLimited complicationsPeripheral arteriesStent implantationEndothelial denudationInflammatory responseClinical studiesNeointimal hyperplasiaTherapeutic strategiesRole of microRNAsTherapeutic targetRestenosisPathological processesLong-term successRole of miRNAsUnderlying mechanism