2024
Heterogeneous gene expression during early arteriovenous fistula remodeling suggests that downregulation of metabolism predicts adaptive venous remodeling
Ohashi Y, Protack C, Aoyagi Y, Gonzalez L, Thaxton C, Zhang W, Kano M, Bai H, Yatsula B, Alves R, Hoshina K, Schneider E, Long X, Perry R, Dardik A. Heterogeneous gene expression during early arteriovenous fistula remodeling suggests that downregulation of metabolism predicts adaptive venous remodeling. Scientific Reports 2024, 14: 13287. PMID: 38858395, PMCID: PMC11164895, DOI: 10.1038/s41598-024-64075-8.Peer-Reviewed Original ResearchConceptsGene expression patternsArteriovenous fistula groupArteriovenous fistulaExpression patternsHeterogeneous gene expressionGene expression changesOutcomes of arteriovenous fistulaVenous remodelingArteriovenous fistula maturationPostoperative day 7Reduce patient morbidityRNA sequencingUpregulation of metabolismBioinformatics analysisGene expressionDownregulation of metabolismMetabolic pathwaysExpression changesGenesAVF maturationAVF remodelingFistula creationC57BL/6 miceClinical outcomesPatient morbidity
2023
Sex hormones impact early maturation and immune response in the arteriovenous fistula mouse model
Satam K, Ohashi Y, Thaxton C, Gonzalez L, Setia O, Bai H, Aoyagi Y, Xie Y, Zhang W, Yatsula B, Martin K, Cai Y, Dardik A. Sex hormones impact early maturation and immune response in the arteriovenous fistula mouse model. AJP Heart And Circulatory Physiology 2023, 325: h77-h88. PMID: 37145957, PMCID: PMC10243550, DOI: 10.1152/ajpheart.00049.2023.Peer-Reviewed Original ResearchConceptsIntact female miceAVF maturationSex hormonesT cellsFemale miceArteriovenous fistulaMale miceMouse modelHigher IL-10Arteriovenous fistula creationImmune cell recruitmentSex-specific therapiesHormone receptor signalingSex differencesHuman AVF maturationAVF surgeryMale patientsClinical outcomesFemale patientsFistula maturationIL-10C57BL/6 miceInferior outcomesVenous adaptationFistula creation
2022
Sex differences in arterial identity correlate with neointimal hyperplasia after balloon injury
Gao M, Gao X, Taniguchi R, Brahmandam A, Matsubara Y, Liu J, Liu H, Zhang W, Dardik A. Sex differences in arterial identity correlate with neointimal hyperplasia after balloon injury. Molecular Biology Reports 2022, 49: 8301-8315. PMID: 35715609, PMCID: PMC9463237, DOI: 10.1007/s11033-022-07644-2.Peer-Reviewed Original ResearchConceptsBalloon injuryFemale ratsArterial remodelingNeointimal proliferationCarotid arteryNeointimal thicknessSex differencesLeft common carotid arteryAtherosclerotic arterial diseaseSmooth muscle cell proliferationRight carotid arteryCarotid balloon injuryMale Sprague-DawleyCommon carotid arteryBaseline sex differencesMuscle cell proliferationErythropoietin-producing hepatocellular (Eph) receptorsBackgroundEndovascular treatmentArterial diseaseArterial injuryClinical outcomesSex hormonesUninjured controlsArterial identitySprague-Dawley
2019
Comparison of clinical outcomes of laparoscopic versus open surgery for recurrent hepatocellular carcinoma: a meta-analysis
Cai W, Liu Z, Xiao Y, Zhang W, Tang D, Cheng B, Li Q. Comparison of clinical outcomes of laparoscopic versus open surgery for recurrent hepatocellular carcinoma: a meta-analysis. Surgical Endoscopy 2019, 33: 3550-3557. PMID: 31342257, DOI: 10.1007/s00464-019-06996-4.Peer-Reviewed Original ResearchConceptsRecurrent hepatocellular carcinomaOpen liver resectionLaparoscopic liver resectionShorter postoperative hospital stayPostoperative hospital stayLiver resectionLess blood lossLaparoscopic groupHospital stayBlood lossClinical outcomesOperative timeOpen groupHepatocellular carcinomaSafe alternative treatment strategyConclusionLaparoscopic liver resectionHospital complication ratesSatisfactory postoperative outcomeSimilar operative timeAlternative treatment strategiesHospital complicationsComplication ratePostoperative outcomesOpen surgeryResultsSix studies