2019
Structural basis for the clamping and Ca2+ activation of SNARE-mediated fusion by synaptotagmin
Grushin K, Wang J, Coleman J, Rothman JE, Sindelar CV, Krishnakumar SS. Structural basis for the clamping and Ca2+ activation of SNARE-mediated fusion by synaptotagmin. Nature Communications 2019, 10: 2413. PMID: 31160571, PMCID: PMC6546687, DOI: 10.1038/s41467-019-10391-x.Peer-Reviewed Original ResearchConceptsCryo-electron microscopy structureActivation of SNAREsDependent membrane interactionsAnionic lipid headgroupsFusion clampActivator functionSNARE bundleSNARE proteinsMicroscopy structureC2B domainStructural basisSynaptotagmin-1SNAREpinsAliphatic loopsMembrane interactionsComplete assemblyLipid headgroupsLipid membranesNeurotransmitter releaseMembraneKey determinantSynaptotagminSyt1Calcium influxPartial insertion
2011
Structural Basis of WHAMM to Regulate Golgi Membrane Transportation via Interacting with Both Microtubules and Membranes
Shen Q, Campellone K, Sindelar C, Welch M, Wang H. Structural Basis of WHAMM to Regulate Golgi Membrane Transportation via Interacting with Both Microtubules and Membranes. Biophysical Journal 2011, 100: 49a. DOI: 10.1016/j.bpj.2010.12.466.Peer-Reviewed Original Research