Grace Chen, PhD
Assistant ProfessorDownloadHi-Res Photo
Cards
Appointments
Immunobiology
Primary
Genetics
Secondary
Contact Info
Immunobiology
300 Cedar Street, TAC S641C, PO Box 208011
New Haven, CT 06520-8011
United States
About
Titles
Assistant Professor
Biography
Grace Chen received her undergraduate training in the College of Chemistry at UC Berkeley. She attended Harvard University for her PhD where she worked in David Liu's laboratory to discover and characterize novel RNA modifications. Her postdoctoral research was at Stanford University in Howard Chang's group, where she investigated circular RNA immunity. Grace joined Yale University as a faculty in the Department of Immunobiology in 2019. Her research focuses on the functions and regulations of circular RNAs and RNA modifications in health and disease.
Appointments
Immunobiology
Assistant ProfessorPrimaryGenetics
Assistant ProfessorSecondary
Other Departments & Organizations
- Cancer Immunology
- Center for RNA Science and Medicine
- Genetics
- Immunobiology
- Immunology
- Molecular Cell Biology, Genetics and Development
- Yale Cancer Center
- Yale Combined Program in the Biological and Biomedical Sciences (BBS)
Education & Training
- Postdoctoral Fellow
- Stanford University (2018)
- PhD
- Harvard University, Chemical Biology (2012)
- BS
- UC Berkeley, Chemical Biology (2005)
Research
Overview
Medical Research Interests
Autoimmune Diseases; Immune System; Immunotherapy; Mass Spectrometry; RNA, Circular; RNA, Double-Stranded
ORCID
0000-0003-3574-5734
Research at a Glance
Yale Co-Authors
Frequent collaborators of Grace Chen's published research.
Research Interests
Research topics Grace Chen is interested in exploring.
Antariksh Tyagi, PhD
RNA, Circular
Publications
2024
A scalable and cost-efficient rRNA depletion approach to enrich RNAs for molecular biology investigations
Singh A, Xue A, Tai J, Mbadugha F, Obi P, Mascarenhas R, Tyagi A, Siena A, Chen Y. A scalable and cost-efficient rRNA depletion approach to enrich RNAs for molecular biology investigations. RNA 2024, 30: rna.079761.123. PMID: 38485192, PMCID: PMC11098455, DOI: 10.1261/rna.079761.123.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsDepleting rRNACellular processesAbundance of rRNAMolecular biological investigationsNon-rRNA transcriptsComplex regulatory networkInvestigate gene expressionRRNA removalRRNA moleculesHistone mRNARegulatory networksSmall RNAsPositive selectionRRNARNA inputBiological investigationsTranscriptome analysisLong noncoding RNAsGene expressionRegulatory mechanismsRNAOff-target effectsNoncoding RNAsCircular RNAsTranscription
2023
Differences in the immunogenicity of engineered circular RNAs
Tai J, Chen Y. Differences in the immunogenicity of engineered circular RNAs. Journal Of Molecular Cell Biology 2023, 15: mjad002. PMID: 36787893, PMCID: PMC10257478, DOI: 10.1093/jmcb/mjad002.Peer-Reviewed Original ResearchCitationsMeSH Keywords
2022
circCsnk1g3- and circAnkib1-regulated interferon responses in sarcoma promote tumorigenesis by shaping the immune microenvironment
Piras R, Ko E, Barrett C, De Simone M, Lin X, Broz M, Tessaro F, Castillo-Martin M, Cordon-Cardo C, Goodridge H, Di Vizio D, Batish M, Lawrenson K, Chen Y, Chan K, Guarnerio J. circCsnk1g3- and circAnkib1-regulated interferon responses in sarcoma promote tumorigenesis by shaping the immune microenvironment. Nature Communications 2022, 13: 7243. PMID: 36433954, PMCID: PMC9700836, DOI: 10.1038/s41467-022-34872-8.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsNon-coding RNA speciesExonic circular RNAsViral RNA sensorsRNA speciesInterferon-related genesSpecific circRNAsCircular RNAsSarcoma cellsCircRNAsRNA sensorsCancer progressionFunctional contributionInterferon responseSoft tissue sarcoma cellsImmune cell recruitmentPro-tumorigenic microenvironmentCellsTumor growthSarcoma growthTumor cellsPro-inflammatory elementsCell recruitmentActivationPro-inflammatory factorsMicroenvironment
Academic Achievements & Community Involvement
honor Allens Distinguished Investigators
National AwardDetails12/03/2021United Stateshonor Rita Allen Foundation Scholars
National AwardDetails09/01/2020United States
News & Links
Get In Touch
Contacts
Mailing Address
Immunobiology
300 Cedar Street, TAC S641C, PO Box 208011
New Haven, CT 06520-8011
United States
Locations
Chen Laboratory
Lab
The Anlyan Center
300 Cedar Street, Ste S540
New Haven, CT 06519