SEICHE Center for Health and Justice

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What Makes a Successful Heart Failure Drug Work?
Researchers across Yale School of Medicine published a new study in The Journal of Clinical Investigation that sheds light on how SGLT2 inhibitors work to protect the heart.
18 Feb 2025
News
Metabolism Expert Cline Retires From YSM
Metabolism Expert Cline Retires From YSM
6 Aug 2021
News
Discoveries & Impact (December 2020)
Discoveries & Impact (December 2020)
16 Dec 2020
News
Discoveries & Impact (September 2020)
Discoveries & Impact (September 2020)
17 Sep 2020
News
PET Imaging of Beta Cell Mass Featured in Journal of Nuclear Medicine
Type 1 diabetes mellitus (T1DM) is characterized by a loss of β-cells in the islets of Langerhans of the pancreas and subsequent deficient insulin secretion in response to hyperglycemia. Development of an in vivo test to measure β-cell mass (BCM) would greatly enhance the ability to track diabetes therapies.
Source: The Journal of Nuclear Medicine
1 Aug 2018
News
Study reveals how a very low calorie diet can reverse type 2 diabetes
In a new study, a Yale-led research team uncovers how a very low calorie diet can rapidly reverse type 2 diabetes in animal models. If confirmed in people, the insight provides potential new drug targets for treating this common chronic disease, said the researchers.
8 Nov 2017
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Fructose is generated in the human brain
Fructose, a form of sugar linked to obesity and diabetes, is converted in the human brain from glucose, according to a new Yale study. The finding raises questions about fructose’s effects on the brain and eating behavior.
22 Feb 2017
News
Gut bacteria differs in obese youth
Obese children and teens have different bacteria living in their digestive tracts than their leaner peers, according to a Yale-led study. The findings could help researchers develop strategies to target specific gut microbes with the goal of preventing or treating obesity in youth, said the researchers.
21 Sep 2016
News
Study reveals how altered gut microbes cause obesity
Obesity is linked to changes in our gut microbes — the trillions of tiny organisms that inhabit our intestines. But the mechanism has not been clear. In a new study published in Nature, a Yale-led team of researchers has identified how an altered gut microbiota causes obesity.
8 Jun 2016
News
Yale Team Receives ACTS Award for Diabetes Research
A team of Yale investigators has been awarded the 2016 Team Science Award from the Association for Clinical and Translational Science (ACTS) for its pioneering work in advancing our understanding of the mechanisms underlying type 2 diabetes.
9 May 2016
News
Diabetes debate: Triglycerides form in liver despite insulin resistance
Solving one of the great mysteries of type 2 diabetes, a team of Yale researchers found that triglycerides, a type of fat in the blood and liver, are produced in the liver independent of insulin action in the liver.
6 Jan 2015
News
How leptin, the ‘satiety hormone,’ reverses diabetes
Treatment with leptin, the hormone associated with fullness or satiety, reverses hyperglycemia in animals models of poorly controlled type 1 (T1D) and type 2 (T2D) diabetes by suppressing the neuroendocrine pathways that cause blood glucose levels to soar, a Yale-led team of researchers has found. The study appears in the Advance Online Publication of Nature Medicine.
16 Jun 2014
News
Reversing key precursors to diabetes
Yale researchers have found a way to disrupt the biological underpinnings of disorders that predispose a person to type 2 diabetes (T2D), raising the possibility of developing therapies to reverse these conditions. The study appears in the journal Cell Metabolism.
4 Nov 2013
News
Mapmakers of the living human body
Imagine trying to develop a drug and being able to see how and where that drug acts inside the body of a living person. Just such a tool is provided by positron emission tomography (PET), an imaging technology that is aiding drug development and research on the mechanisms of disease at the School of Medicine’s state-of-the-art PET Center.
Source: Medicine@Yale
4 Apr 2013
News
Preventing diabetes: Yale researchers measure loss of human pancreas cells
A Yale University-led research team has developed a way to measure the loss of insulin-producing islet cells in the human pancreas. The death of those beta cells leads to diabetes. The finding is a crucial step in developing therapies to preserve insulin production and slow or halt the progress of diabetes.
1 Jun 2012
News
Yale Researchers Enlist a New Recruit in Battle of the Bulge
In the battle against obesity, Yale University researchers may have discovered a new weapon — a naturally occurring molecule secreted by the gut that makes rats and mice less hungry after fatty meals. The findings are published in the Nov. 26 issue of the journal Cell.
25 Nov 2008
News
Brain Plays Key Role in Appetite by Regulating Free Radicals
Researchers at Yale School of Medicine have found the brain’s appetite center uses fat for fuel by involving oxygen free radicals—molecules associated with aging and neurodegeneration. The findings, reported in the journal Nature, suggest that antioxidants could play a role in weight control.
30 Jul 2008
News
Yale's Shulman Honored for Diabetes Research
Gerald I. Shulman, M.D., professor of internal medicine and cellular & molecular physiology at the Yale School of Medicine, is the 2008 recipient of the Stanley J. Korsmeyer award for his outstanding contributions to the understanding of insulin resistance and type 2 diabetes.
15 Apr 2008