2016
WAC Regulates mTOR Activity by Acting as an Adaptor for the TTT and Pontin/Reptin Complexes
David-Morrison G, Xu Z, Rui Y, Charng W, Jaiswal M, Yamamoto S, Xiong B, Zhang K, Sandoval H, Duraine L, Zuo Z, Zhang S, Bellen H. WAC Regulates mTOR Activity by Acting as an Adaptor for the TTT and Pontin/Reptin Complexes. Developmental Cell 2016, 36: 139-151. PMID: 26812014, PMCID: PMC4730548, DOI: 10.1016/j.devcel.2015.12.019.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAutophagyCarrier ProteinsDNA HelicasesDrosophila melanogasterDrosophila ProteinsMonomeric GTP-Binding ProteinsProtein MultimerizationSignal TransductionTOR Serine-Threonine KinasesConceptsPontin/Reptin complexMTOR activityRapamycin complex 1Energy statusRegulation of metabolismEnergy-dependent activationDrosophila screenEnergy-dependent mannerTTT complexRAG interactionsMTORC1 activityMechanistic targetReptinPhysical interactionRegulatorDimerizationNeuronal dysfunctionComplexesPontinHomologActivationComplexes 1AdaptorAutophagyMTOR
2015
A rapid, membrane-dependent pathway directs furrow formation through RalA in the early Drosophila embryo
Holly R, Mavor L, Zuo Z, Blankenship J. A rapid, membrane-dependent pathway directs furrow formation through RalA in the early Drosophila embryo. Development 2015, 142: 2316-2328. PMID: 26092850, PMCID: PMC4510590, DOI: 10.1242/dev.120998.Peer-Reviewed Original ResearchConceptsEarly Drosophila embryoDrosophila embryosFurrow formationPlasma membraneRalA functionMembrane trafficking pathwaysEarly syncytial Drosophila embryoExocyst complex subunitsEarly fly embryoSyncytial Drosophila embryosWild-type embryosMyosin II functionF-actin recruitmentExocyst complexExocytic vesiclesMembrane traffickingFly embryoTrafficking pathwaysComplex subunitsFurrow ingressionChromosomal segregationCytoskeletal remodelingCell divisionCytokinetic furrowRalA