Uncoupling neuronal death and dysfunction in Drosophila models of neurodegenerative disease
Chouhan A, Guo C, Hsieh Y, Ye H, Senturk M, Zuo Z, Li Y, Chatterjee S, Botas J, Jackson G, Bellen H, Shulman J. Uncoupling neuronal death and dysfunction in Drosophila models of neurodegenerative disease. Acta Neuropathologica Communications 2016, 4: 62. PMID: 27338814, PMCID: PMC4918017, DOI: 10.1186/s40478-016-0333-4.Peer-Reviewed Original ResearchMeSH KeywordsAgingAlpha-SynucleinAmyloid beta-PeptidesAnimalsAnimals, Genetically ModifiedCell DeathDisease Models, AnimalDrosophilaElectroretinographyFemaleHumansMembrane PotentialsMicroelectrodesMicroscopy, Electron, TransmissionNeurodegenerative DiseasesNeuronsPeptide FragmentsRetinaTau ProteinsVision, OcularConceptsAdult Drosophila retinaToxic protein speciesDisease-relevant proteinsMicrotubule-associated protein tauMedium-throughput assaysProgressive photoreceptor cell deathCodon-optimized transgeneCommon neurodegenerative proteinopathiesAdult nervous systemDrosophila retinaNeuronal deathProtein speciesGlial cell typesDrosophila modelParkinson's diseaseNervous systemAlzheimer's diseaseAge-dependent neuronal lossPhotoreceptor cell deathCell deathCell typesProtein tauDrosophilaExpression of tauPotential degenerative changes