Featured Publications
Disparities in Excess Mortality Associated with COVID-19 — United States, 2020
Rossen LM, Ahmad FB, Anderson RN, Branum AM, Du C, Krumholz HM, Li SX, Lin Z, Marshall A, Sutton PD, Faust JS. Disparities in Excess Mortality Associated with COVID-19 — United States, 2020. MMWR Morbidity And Mortality Weekly Report 2021, 70: 1114-1119. PMID: 34411075, PMCID: PMC8375709, DOI: 10.15585/mmwr.mm7033a2.Peer-Reviewed Original ResearchConceptsMortality incidence ratesIncidence rateExcess mortalityAge groupsHighest excess mortality ratesExcess Mortality AssociatedGreater excess mortalityExcess mortality ratesAI/AN populationsNon-Hispanic American IndianNon-Hispanic blacksNational Vital Statistics SystemCOVID-19 pandemicPublic health messagingNon-Hispanic white populationRace/ethnicityVital Statistics SystemMortality AssociatedLack of adjustmentMortality rateExcess deathsAN populationsEthnic groupsHealth messagingHispanic persons
2024
Racial and Ethnic Disparities in Age-Specific All-Cause Mortality During the COVID-19 Pandemic
Faust J, Renton B, Bongiovanni T, Chen A, Sheares K, Du C, Essien U, Fuentes-Afflick E, Haywood T, Khera R, King T, Li S, Lin Z, Lu Y, Marshall A, Ndumele C, Opara I, Loarte-Rodriguez T, Sawano M, Taparra K, Taylor H, Watson K, Yancy C, Krumholz H. Racial and Ethnic Disparities in Age-Specific All-Cause Mortality During the COVID-19 Pandemic. JAMA Network Open 2024, 7: e2438918. PMID: 39392630, PMCID: PMC11581672, DOI: 10.1001/jamanetworkopen.2024.38918.Peer-Reviewed Original ResearchConceptsCOVID-19 public health emergencyNon-HispanicPublic health emergencyOther Pacific IslanderExcess mortalityAlaska NativesUS populationExcess deathsRates of excess mortalityCross-sectional study analyzed dataYears of potential lifeMortality relative riskNon-Hispanic whitesCross-sectional studyPacific IslandersStudy analyzed dataAll-cause mortalityEthnic groupsMortality disparitiesMortality ratioTotal populationDeath certificatesEthnic disparitiesMain OutcomesDecedent age
2020
Seroprevalence of SARS-CoV-2-Specific IgG Antibodies Among Adults Living in Connecticut: Post-Infection Prevalence (PIP) Study
Mahajan S, Srinivasan R, Redlich CA, Huston SK, Anastasio KM, Cashman L, Massey DS, Dugan A, Witters D, Marlar J, Li SX, Lin Z, Hodge D, Chattopadhyay M, Adams MD, Lee C, Rao LV, Stewart C, Kuppusamy K, Ko AI, Krumholz HM. Seroprevalence of SARS-CoV-2-Specific IgG Antibodies Among Adults Living in Connecticut: Post-Infection Prevalence (PIP) Study. The American Journal Of Medicine 2020, 134: 526-534.e11. PMID: 33130124, PMCID: PMC7598362, DOI: 10.1016/j.amjmed.2020.09.024.Peer-Reviewed Original ResearchConceptsSARS-CoV-2-specific IgG antibodiesWeighted seroprevalenceIgG antibodiesSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2) antibodiesSARS-CoV-2-specific antibodiesConnecticut residentsSelf-reported adherenceImmunoglobulin G antibodiesSARS-CoV-2Symptomatic illnessSerology testingSeroprevalence studyG antibodiesPrevalence studyGeneral populationPercentage of peopleSeroprevalenceLack antibodiesMajority of respondentsAntibodiesHispanic subpopulationsConvenience sampleHispanic populationCOVID-19Risk mitigation behaviors
2018
The influence of sociodemographic factors on operative decision-making in small bowel obstruction
Jean RA, Chiu AS, O'Neill KM, Lin Z, Pei KY. The influence of sociodemographic factors on operative decision-making in small bowel obstruction. Journal Of Surgical Research 2018, 227: 137-144. PMID: 29804845, DOI: 10.1016/j.jss.2018.02.029.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAged, 80 and overClinical Decision-MakingDigestive System Surgical ProceduresFemaleHealth Care CostsHealthcare DisparitiesHospitalizationHumansInpatientsInsurance CoverageIntestinal ObstructionIntestine, SmallLength of StayMaleMiddle AgedPractice Guidelines as TopicRacial GroupsRetrospective StudiesSocioeconomic FactorsTime-to-TreatmentUnited StatesYoung AdultConceptsSmall bowel obstructionOperative managementOperative delaySociodemographic factorsBowel obstructionHospital factorsInsurance statusMedicare patientsUtilization Project National Inpatient SampleMedicare insurance coverageOverall study populationNational Inpatient SampleHospital mortalityNonoperative therapyNonoperative managementHospital clusteringPrimary outcomeHispanic patientsBlack patientsPrimary diagnosisInpatient SampleCurrent guidelinesSociodemographic disparitiesStudy populationHealthcare costsDefining Multiple Chronic Conditions for Quality Measurement
Drye EE, Altaf FK, Lipska KJ, Spatz ES, Montague JA, Bao H, Parzynski CS, Ross JS, Bernheim SM, Krumholz HM, Lin Z. Defining Multiple Chronic Conditions for Quality Measurement. Medical Care 2018, 56: 193-201. PMID: 29271820, DOI: 10.1097/mlr.0000000000000853.Peer-Reviewed Original ResearchConceptsMultiple chronic conditionsChronic conditionsMedicare feeService beneficiariesMedicare Chronic Conditions WarehouseMCC cohortBroad cohortChronic Conditions WarehouseRisk-standardized ratesNational quality measuresUnplanned admissionsFinal cohortTotal admissionsAdmission riskAccountable care organizationsAdmission ratesOutcome measuresAdmissionCohortCohort conditionCare organizationsPatientsStakeholder inputNarrow cohortBeneficiaries
2015
National trends in hospital length of stay for acute myocardial infarction in China
Li Q, Lin Z, Masoudi FA, Li J, Li X, Hernández-Díaz S, Nuti SV, Li L, Wang Q, Spertus JA, Hu FB, Krumholz HM, Jiang L. National trends in hospital length of stay for acute myocardial infarction in China. BMC Cardiovascular Disorders 2015, 15: 9. PMID: 25603877, PMCID: PMC4360951, DOI: 10.1186/1471-2261-15-9.Peer-Reviewed Original Research
2010
Telemonitoring in Patients with Heart Failure
Chaudhry SI, Mattera JA, Curtis JP, Spertus JA, Herrin J, Lin Z, Phillips CO, Hodshon BV, Cooper LS, Krumholz HM. Telemonitoring in Patients with Heart Failure. New England Journal Of Medicine 2010, 363: 2301-2309. PMID: 21080835, PMCID: PMC3237394, DOI: 10.1056/nejmoa1010029.Peer-Reviewed Original ResearchConceptsPrimary end pointUsual care groupSecondary end pointsHeart failureEnd pointHeart failure outcomesNumber of hospitalizationsTelephone-based interactive voice response systemUsual careAdverse eventsPatient's clinicianMedian ageCare groupLarge trialsInteractive voice response systemPatientsSmall studyVoice response systemNumber of daysHospitalizationReadmissionTelemonitoringSignificant differencesCliniciansDeath
2007
Changes in outcomes for internal medicine inpatients after work-hour regulations.
Horwitz LI, Kosiborod M, Lin Z, Krumholz HM. Changes in outcomes for internal medicine inpatients after work-hour regulations. Annals Of Internal Medicine 2007, 147: 97-103. PMID: 17548401, DOI: 10.7326/0003-4819-147-2-200707170-00163.Peer-Reviewed Original ResearchConceptsIntensive care unit utilizationLength of stayDrug-drug interactionsWork-hour regulationsNonteaching servicesHospital deathPharmacist interventionsReadmission ratesConsecutive patientsRetrospective cohort studyInternal medicine patientsInternal medicine inpatientsUnit utilizationAdverse drug-drug interactionsTeaching serviceAcademic medical centerCohort studyDischarge dispositionMedicine inpatientsMedicine patientsFatigue-related errorsMedical CenterRehabilitation facilityRate of dischargePatients
2003
Gender differences in recovery after coronary artery bypass surgery
Vaccarino V, Lin ZQ, Kasl SV, Mattera JA, Roumanis SA, Abramson JL, Krumholz HM. Gender differences in recovery after coronary artery bypass surgery. Journal Of The American College Of Cardiology 2003, 41: 307-314. PMID: 12535827, DOI: 10.1016/s0735-1097(02)02698-0.Peer-Reviewed Original ResearchConceptsPhysical functionCABG surgeryDepressive symptomsHospital readmissionCoronary artery bypass graft surgeryArtery bypass graft surgeryCoronary artery bypass surgeryBypass graft surgeryArtery bypass surgeryCongestive heart failureLow physical functionMore depressive symptomsFirst CABGGraft surgeryBaseline characteristicsBypass surgeryPatient characteristicsHeart failureIllness severityMedical recordsWorse outcomesClinical dataFemale genderHigh riskSide effects
2000
Impact of Guglielmi detachable coils on outcomes of patients with intracranial aneurysms treated by a multidisciplinary team at a single institution.
Sturaitis M, Rinne J, Chaloupka J, Kaynar M, Lin Z, Awad I. Impact of Guglielmi detachable coils on outcomes of patients with intracranial aneurysms treated by a multidisciplinary team at a single institution. Journal Of Neurosurgery 2000, 93: 569-80. PMID: 11014534, DOI: 10.3171/jns.2000.93.4.0569.Peer-Reviewed Original ResearchConceptsIntensive care unitInflation-adjusted hospital chargesHospital chargesClinical outcomesTherapeutic optionsIntracranial aneurysmsDuration of hospitalOutcomes of patientsPoor surgical risksAcademic referral centerLength of stayOverall management outcomeGuglielmi detachable coilsHigher clinical gradeEffectiveness of treatmentDisease severity parametersComputerized tomography scanningGDC procedureHospital stayIntradural aneurysmsReferral centerSurgical riskCare unitTertiary careOutcome parameters