2023
Radiobiological evaluation of the stepping-source effect in single-fraction monotherapy high-dose-rate prostate brachytherapy
Tien C, Chen Z. Radiobiological evaluation of the stepping-source effect in single-fraction monotherapy high-dose-rate prostate brachytherapy. Brachytherapy 2023, 22: 593-606. PMID: 37263898, DOI: 10.1016/j.brachy.2023.03.003.Peer-Reviewed Original ResearchDose prescription and reporting in stereotactic body radiotherapy: A multi-institutional study
Das I, Yadav P, Andersen A, Chen Z, Huang L, Langer M, Lee C, Li L, Popple R, Rice R, Schiff P, Zhu T, Abazeed M. Dose prescription and reporting in stereotactic body radiotherapy: A multi-institutional study. Radiotherapy And Oncology 2023, 182: 109571. PMID: 36822361, PMCID: PMC10121952, DOI: 10.1016/j.radonc.2023.109571.Peer-Reviewed Original ResearchConceptsDose prescriptionTreatment-related toxicityClinical outcome comparisonStereotactic body radiotherapyMulti-institutional studyTreatment guidelinesTreatment disparitiesBody radiotherapyPTV volumeClinical trialsTreatment protocolOutcome comparisonsTreatment efficacyAbstractTextHypofractionated treatmentDosimetric parametersDose parametersDosimetric variabilityDosimetric variationsStandardized reportingLack of standardizationPreliminary dosimetric comparison between fixed and rotating source stereotactic radiosurgery systems
Draeger E, Chen Z, Hansen J, Chiang V, Tien C. Preliminary dosimetric comparison between fixed and rotating source stereotactic radiosurgery systems. Journal Of Applied Clinical Medical Physics 2023, 24: e13907. PMID: 36660774, PMCID: PMC10161057, DOI: 10.1002/acm2.13907.Peer-Reviewed Original ResearchConceptsConformity indexRadiation Therapy Oncology Group conformity indexGK plansSuperior conformity indexNon-metastatic casesPaddick conformity indexDosimetric plan qualityGK patientsBrain metastasesRadiosurgery systemTrigeminal neuralgiaPrescription dosesGamma Knife systemMetastatic casesArteriovenous malformationsPituitary adenomasConformality indexLarge cohortDosimetric comparisonStereotactic radiosurgery systemGK IconPatientsCohortTreatment timeDosimetric results
2022
Frequency of errors in the transfer of treatment parameters from the treatment planning system to the oncology information system in a multi‐vendor environment
Donahue W, Draeger E, Han D, Chen Z. Frequency of errors in the transfer of treatment parameters from the treatment planning system to the oncology information system in a multi‐vendor environment. Journal Of Applied Clinical Medical Physics 2022, 24: e13868. PMID: 36527239, PMCID: PMC10113690, DOI: 10.1002/acm2.13868.Peer-Reviewed Original ResearchConceptsInformation systemsTransfer of dataPlanning systemSoftware systemsOncology information systemMultiple vendorsData transferField labelsData inputTimer settingsNumber of errorsTechnological advancementsErrorSystemVendorsAdvancementTreatment planning systemFrequency of errorsMOSAIQCommon errorsLabelsInformationA small footprint couch‐top support device for image‐guided radiotherapy of heavy patients
Chen H, Morley K, Rodriguez R, Draeger E, Hassan M, Chen Z. A small footprint couch‐top support device for image‐guided radiotherapy of heavy patients. Journal Of Applied Clinical Medical Physics 2022, 23: e13788. PMID: 36267043, PMCID: PMC9797158, DOI: 10.1002/acm2.13788.Peer-Reviewed Original ResearchSkin dose distributions between Stanford and rotational techniques in total skin electron therapy (TSET)
Ding G, Chen Z, Zhong W, Zhu T. Skin dose distributions between Stanford and rotational techniques in total skin electron therapy (TSET). Medical Physics 2022, 49: 6646-6653. PMID: 35972019, DOI: 10.1002/mp.15907.Peer-Reviewed Original ResearchConceptsTotal skin electron therapyDose coverageStanford techniqueAdvanced-stage cutaneous T-cell lymphomaCutaneous T-cell lymphomaSkin dose distributionRotational techniqueT-cell lymphomaPatient's postureSimilar dose coverageDose distributionExtended treatment distancesElectron therapyMean doseEffective treatmentSame patientSmall dose differencesClinical settingPatient treatmentSkin dosesRealistic clinical settingsSkin doseDoseDifferent posturesDistribution of doseDosimetric study of Varian Universal Multi-Channel Cylinder System for High-Dose-Rate 192Ir Brachytherapy
Tien CJ, Damast S, Chen ZJ. Dosimetric study of Varian Universal Multi-Channel Cylinder System for High-Dose-Rate 192Ir Brachytherapy. Brachytherapy 2022, 21: 244-254. PMID: 34996715, DOI: 10.1016/j.brachy.2021.11.001.Peer-Reviewed Original Research
2021
Reflections on Anthony Zietman From Gastrointestinal Cancer and Physics Editors
Willett GCECG, Chang DT, Czito BG, Liauw SL, Wo JY, Klein PEE, Chen Z, Carlson DJ, Chetty IJ. Reflections on Anthony Zietman From Gastrointestinal Cancer and Physics Editors. International Journal Of Radiation Oncology • Biology • Physics 2021, 111: 1114-1117. PMID: 34793734, DOI: 10.1016/j.ijrobp.2021.09.007.Peer-Reviewed Original Research
2020
Clinically-implementable template plans for multidwell treatments using Leipzig-style applicators in 192Ir surface brachytherapy
Draeger E, Pinkham DW, Chen ZJ, Tien CJ. Clinically-implementable template plans for multidwell treatments using Leipzig-style applicators in 192Ir surface brachytherapy. Brachytherapy 2020, 20: 401-409. PMID: 33288488, DOI: 10.1016/j.brachy.2020.09.019.Peer-Reviewed Original ResearchA prototype open-ended multichannel intracavitary-interstitial hybrid applicator for gynecological high-dose-rate brachytherapy
Tien CJ, Chen Z. A prototype open-ended multichannel intracavitary-interstitial hybrid applicator for gynecological high-dose-rate brachytherapy. Radiological Physics And Technology 2020, 13: 187-194. PMID: 32424632, DOI: 10.1007/s12194-020-00567-2.Peer-Reviewed Original ResearchConceptsPrescription doseRate brachytherapyHybrid applicatorPrior patientsRisk doseMinimum doseOAR D2ccMultichannel applicatorCentral tandemDoseTarget coverageInterstitial needlesPatientsApplicator bodyBrachytherapyDistal endOpen distal endsPeripheral needlesPeripheral channelsSilico studiesNeedleBowelBladderD2ccRectumFeasibility of using multiple-dwell positions in 192Ir Leipzig-style brachytherapy surface applicators to expand target coverage and clinical application
Tien CJ, Pinkham DW, Chen ZJ. Feasibility of using multiple-dwell positions in 192Ir Leipzig-style brachytherapy surface applicators to expand target coverage and clinical application. Brachytherapy 2020, 19: 532-543. PMID: 32327342, DOI: 10.1016/j.brachy.2020.03.002.Peer-Reviewed Original Research
2019
Deployment and performance of model-based dose calculation algorithm in 192Ir shielded cylinder brachytherapy
Tien CJ, Chen ZJ. Deployment and performance of model-based dose calculation algorithm in 192Ir shielded cylinder brachytherapy. Brachytherapy 2019, 18: 883-889. PMID: 31444132, DOI: 10.1016/j.brachy.2019.07.006.Peer-Reviewed Original ResearchHigh-dose-rate brachytherapy as monotherapy for prostate cancer: The impact of cellular repair and source decay
Tien CJ, Carlson DJ, Nath R, Chen ZJ. High-dose-rate brachytherapy as monotherapy for prostate cancer: The impact of cellular repair and source decay. Brachytherapy 2019, 18: 701-710. PMID: 31109870, DOI: 10.1016/j.brachy.2019.04.005.Peer-Reviewed Original ResearchAdaptive Imaging Versus Periodic Surveillance for Intrafraction Motion Management During Prostate Cancer Radiotherapy
Ma X, Yan H, Nath R, Chen Z, Li H, Liu W. Adaptive Imaging Versus Periodic Surveillance for Intrafraction Motion Management During Prostate Cancer Radiotherapy. Technology In Cancer Research & Treatment 2019, 18: 1533033819844489. PMID: 31177934, PMCID: PMC6558533, DOI: 10.1177/1533033819844489.Peer-Reviewed Original ResearchConceptsIntensity-modulated radiation therapyRadiation therapyCouch shiftsAutomatic motion compensationAdaptive imagingAutomatic correctionCurrent clinical situationProstate cancer radiotherapyImaging surveillanceMotion compensationPeriodic imaging surveillanceProstate cancerPeriodic surveillanceClinical situationsSurveillance strategiesBenefits of adaptivePeriodic imagingArc therapyMean percentageTherapyIntrafraction motion managementCancer radiotherapyRadiation therapy simulationTherapy simulationBeam delivery
2018
Extended duration of dilator use beyond 1 year may reduce vaginal stenosis after intravaginal high-dose-rate brachytherapy
Stahl JM, Qian JM, Tien CJ, Carlson DJ, Chen Z, Ratner ES, Park HS, Damast S. Extended duration of dilator use beyond 1 year may reduce vaginal stenosis after intravaginal high-dose-rate brachytherapy. Supportive Care In Cancer 2018, 27: 1425-1433. PMID: 30187220, DOI: 10.1007/s00520-018-4441-5.Peer-Reviewed Original ResearchConceptsVaginal stenosisEndometrial carcinomaMultivariable Cox proportional hazardsMultivariable Cox regression analysisVD useAcademic tertiary referral centerTertiary referral centerCox regression analysisLog-rank testCox proportional hazardsDevelopment of gradeDilator usePelvic radiotherapyReferral centerNoncompliant patientsPrimary outcomeAdjuvant brachytherapyEC patientsConclusionsThe riskRate brachytherapyProportional hazardsOptimal durationPatientsBrachytherapyStudy period
2017
On the use of bolus for pacemaker dose measurement and reduction in radiation therapy
Yan H, Guo F, Zhu D, Stryker S, Trumpore S, Roberts K, Higgins S, Nath R, Chen Z, Liu W. On the use of bolus for pacemaker dose measurement and reduction in radiation therapy. Journal Of Applied Clinical Medical Physics 2017, 19: 125-131. PMID: 29152840, PMCID: PMC5768029, DOI: 10.1002/acm2.12229.Peer-Reviewed Original ResearchDose-Volume Predictors of Esophagitis After Thoracic Stereotactic Body Radiation Therapy
Harder EM, Chen Z, Park HS, Mancini BR, Decker RH. Dose-Volume Predictors of Esophagitis After Thoracic Stereotactic Body Radiation Therapy. American Journal Of Clinical Oncology 2017, 40: 477-482. PMID: 26017483, DOI: 10.1097/coc.0000000000000195.Peer-Reviewed Original ResearchConceptsStepwise selection techniqueRadiation therapyThoracic stereotactic body radiation therapyStereotactic hypofractionated radiation therapyStereotactic body radiation therapyDose-volume predictorsNormal tissue complication probabilityHypofractionated radiation therapyMultivariate logistic regressionProbability estimatesBody radiation therapyPlanning target volumeEsophageal toxicityEsophagitis ratesCTCAE v4.0Dosimetric predictorsPulmonary tumorsInstitutional databaseRadiotherapy parametersLocal DNA Repair Inhibition for Sustained Radiosensitization of High-Grade Gliomas
King AR, Corso CD, Chen EM, Song E, Bongiorni P, Chen Z, Sundaram RK, Bindra RS, Saltzman WM. Local DNA Repair Inhibition for Sustained Radiosensitization of High-Grade Gliomas. Molecular Cancer Therapeutics 2017, 16: 1456-1469. PMID: 28566437, PMCID: PMC5545124, DOI: 10.1158/1535-7163.mct-16-0788.Peer-Reviewed Original ResearchConceptsHigh-grade gliomasPoor blood-brain barrier penetrationLocal disease progressionBlood-brain barrier penetrationEffect of radiotherapyIntrinsic pontine gliomaTreatment of glioblastomaMol Cancer TherCranial radiationDosing schedulesMultimodal treatmentIntracranial gliomasDisease progressionExtracranial tumorsPontine gliomaAggressive phenotypeRadiotherapy approachesGliomasMinimal toxicityRadiotherapyGlioblastomaBarrier penetrationTreatmentRadiosensitizerChemotherapyIncorporating patient-specific CT-based ophthalmic anatomy in modeling iodine-125 eye plaque brachytherapy dose distributions
Tien CJ, Astrahan MA, Kim JM, Materin M, Chen Z, Nath R, Liu W. Incorporating patient-specific CT-based ophthalmic anatomy in modeling iodine-125 eye plaque brachytherapy dose distributions. Brachytherapy 2017, 16: 1057-1064. PMID: 28778599, DOI: 10.1016/j.brachy.2017.06.014.Peer-Reviewed Original ResearchConceptsEye modelDisc distanceDose differenceTumor apexPrescription doseOcular parametersPlaque SimulatorOcular structuresSubstantial dose differencesTarget volumePlaque positionDosimetric parametersPatientsClinical planningDosimetric impactSignificant differencesBrachytherapy planningSeed strengthPlaquesBrachytherapy dose distributionsDose distributionPatient-specific modelsDifferencesTumorsRetinaComparison of 2D and 3D modeled tumor motion estimation/prediction for dynamic tumor tracking during arc radiotherapy
Liu W, Ma X, Yan H, Chen Z, Nath R, Li H. Comparison of 2D and 3D modeled tumor motion estimation/prediction for dynamic tumor tracking during arc radiotherapy. Physics In Medicine And Biology 2017, 62: n168-n179. PMID: 28263949, DOI: 10.1088/1361-6560/aa64c8.Peer-Reviewed Original ResearchConceptsSystem latencyMotion trackingReal-time imaging techniqueMotion compensation frameworkTracking accuracyBeam directionRespiratory motion dataEstimation/predictionPotential dosimetric advantagesAdditional kVTumor trackingDepth directionTracking latencyView planeDosimetric advantagesMotion dataTracking errorDynamic tumor trackingImaging techniquesBlockage problemDetection errorBlockage issueUnresolved motionTrackingCompensation framework