2017
The portal hypertension syndrome: etiology, classification, relevance, and animal models
Bosch J, Iwakiri Y. The portal hypertension syndrome: etiology, classification, relevance, and animal models. Hepatology International 2017, 12: 1-10. PMID: 29064029, DOI: 10.1007/s12072-017-9827-9.BooksMeSH KeywordsAdrenergic beta-AntagonistsAnimalsAscitesCarcinoma, HepatocellularEarly Detection of CancerEsophageal and Gastric VaricesGastrointestinal HemorrhageHealthy LifestyleHemorrhageHepatic EncephalopathyHepatic VeinsHumansHypertension, PortalHypolipidemic AgentsLigationLiver CirrhosisLiver NeoplasmsModels, AnimalPrognosisSimvastatinConceptsHepatic vein pressure gradientNon-bleeding complicationsPortal hypertensionLiver transplantationDisease stagePortal hypertension syndromeAccurate risk stratificationDevelopment of varicesEndoscopic band ligationAim of treatmentPresent day therapyHealthy life styleBackgroundPortal hypertensionDecompensated patientsHVPG responseRefractory ascitesVariceal bleedingClinical decompensationLarge varicesBand ligationDay therapyHepatic encephalopathyBetter prognosisRisk stratificationEtiologic treatment
2013
Carvedilol for preventing recurrent variceal bleeding: Waiting for convincing evidence
Bosch J, Groszmann R, Iwakiri Y, Taddei T. Carvedilol for preventing recurrent variceal bleeding: Waiting for convincing evidence. Hepatology 2013, 57: 1665-1667. PMID: 23359118, DOI: 10.1002/hep.26279.Peer-Reviewed Original ResearchCarvedilol groupSevere adverse eventsVariceal bleedingAdverse eventsVariceal rebleedingRecurrent bleedingI groupControl of acute esophageal variceal bleedingPrevention of gastroesophageal variceal rebleedingPreventing recurrent variceal bleedingAcute esophageal variceal bleedingDecrease portal pressureRecurrent upper gastrointestinal bleedingRecurrent variceal bleedingEsophageal variceal bleedingUpper gastrointestinal bleedingMedian followEsophageal varicesGastric varicesPortal pressureGastrointestinal bleedingIsosorbide mononitrateBleedingCarvedilolPatients