2020
Origin and Function of Stress-Induced IL-6 in Murine Models
Qing H, Desrouleaux R, Israni-Winger K, Mineur YS, Fogelman N, Zhang C, Rashed S, Palm NW, Sinha R, Picciotto MR, Perry RJ, Wang A. Origin and Function of Stress-Induced IL-6 in Murine Models. Cell 2020, 182: 372-387.e14. PMID: 32610084, PMCID: PMC7384974, DOI: 10.1016/j.cell.2020.05.054.Peer-Reviewed Original ResearchMeSH KeywordsAdipose Tissue, BrownAnimalsBone Marrow CellsBone Marrow TransplantationBrainChemokinesCytokinesDisease Models, AnimalGluconeogenesisHyperglycemiaInterleukin-6LiverMaleMiceMice, Inbred C57BLMice, KnockoutReceptors, Adrenergic, beta-3Receptors, Interleukin-6Stress, PsychologicalUncoupling Protein 1ConceptsInterleukin-6Subsequent inflammatory challengeAcute psychological stressBrown adipose tissueDominant cytokineImmunometabolic reprogrammingInflammatory challengeEndocrine organMurine modelMouse modelAdipose tissueNeuropsychiatric diseasesAcute stressHepatic gluconeogenesisStress hormonesBrown adipocytesPsychological stressDependent fashionDiseaseInstructive signalsHyperglycemiaInflammationCytokinesMortalityHormone
2016
Comparative mRNA analysis of behavioral and genetic mouse models of aggression
Malki K, Tosto MG, Pain O, Sluyter F, Mineur YS, Crusio WE, de Boer S, Sandnabba KN, Kesserwani J, Robinson E, Schalkwyk LC, Asherson P. Comparative mRNA analysis of behavioral and genetic mouse models of aggression. American Journal Of Medical Genetics Part B Neuropsychiatric Genetics 2016, 171: 427-436. PMID: 26888158, DOI: 10.1002/ajmg.b.32424.Peer-Reviewed Original ResearchConceptsProbe setsExpression of genesGenetic mouse studiesGene hubsGene networksProtein degradationCandidate genesERG2 geneNetwork analysisGenetic mouse modelsDiscovery-replication designRedox pathwaysGenesP38 MAPKAggression-related traitsMouse modelMouse brain tissueGenetic modelsMRNA studiesMRNA analysisDiscovery studiesDiscovery setPathwayMouse studiesSignificant overlap
2015
Pervasive and opposing effects of Unpredictable Chronic Mild Stress (UCMS) on hippocampal gene expression in BALB/cJ and C57BL/6J mouse strains
Malki K, Mineur YS, Tosto MG, Campbell J, Karia P, Jumabhoy I, Sluyter F, Crusio WE, Schalkwyk LC. Pervasive and opposing effects of Unpredictable Chronic Mild Stress (UCMS) on hippocampal gene expression in BALB/cJ and C57BL/6J mouse strains. BMC Genomics 2015, 16: 262. PMID: 25879669, PMCID: PMC4412144, DOI: 10.1186/s12864-015-1431-6.Peer-Reviewed Original ResearchConceptsWeighted gene coexpression network analysisGene networksGene expressionStress responseHippocampal gene expressionGene coexpression network analysisNumber of genesCandidate gene selectionCoexpression network analysisUbiquitin C geneGene expression studiesGenomic levelGENDEP projectGene pathwaysCandidate genesExpression studiesPathway analysisMolecular mechanismsC geneEnvironmental stressorsGenesGene selectionCREB1 geneBALB/cJAdverse environments