A Novel CaV1.2 N Terminus Expressed in Smooth Muscle Cells of Resistance Size Arteries Modifies Channel Regulation by Auxiliary Subunits*
Cheng X, Liu J, Asuncion-Chin M, Blaskova E, Bannister J, Dopico A, Jaggar J. A Novel CaV1.2 N Terminus Expressed in Smooth Muscle Cells of Resistance Size Arteries Modifies Channel Regulation by Auxiliary Subunits*. Journal Of Biological Chemistry 2007, 282: 29211-29221. PMID: 17699517, PMCID: PMC2276565, DOI: 10.1074/jbc.m610623200.Peer-Reviewed Original ResearchConceptsExon 1cN-terminusExon 1bAuxiliary subunitsRich N-terminusCysteine-rich N-terminusNovel alternative splicingResistance-size cerebral arteriesPlasma membrane insertionExon 1Arterial myocytesMultiple vascular functionsIsoform-dependent differencesWhole-cell current densityN-terminal variantsAlternative splicingMembrane insertionChannel regulationExon 1AMolecular identityHuman diseasesSubunitsTerminusEntry pathwaySmooth muscle cellsMyocytes of resistance‐size arteries express CaV1.2 channels with a novel N‐terminus
Cheng X, Liu J, Blaskova E, Asuncion‐Chin M, Bondarenko A, Dopico A, Jaggar J. Myocytes of resistance‐size arteries express CaV1.2 channels with a novel N‐terminus. The FASEB Journal 2007, 21: a1240-a1240. DOI: 10.1096/fasebj.21.6.a1240-c.Peer-Reviewed Original ResearchResistance-size arteriesIBa densityVoltage-dependent L-type Ca2Resistance-sized cerebral arteriesL-type Ca2Tissue-specific Ca2Cerebral arteryArterial myocytesSmall arteriesVascular pressuresBlood flowArteryCav1.2 geneCardiac myocytesMyocytesCav1.2 channelsCaV1.2 currentsCav1.2 subunitCysteine-rich N-terminusEntry pathwayHalf activationSpecific Ca2Principal Ca2ß-subunitHalf inactivation