2018
The Role of Melanin-Concentrating Hormone in the Regulation of the Sleep/Wake Cycle: Sleep Promoter or Arousal Modulator?
Gao X. The Role of Melanin-Concentrating Hormone in the Regulation of the Sleep/Wake Cycle: Sleep Promoter or Arousal Modulator? 2018, 57-74. DOI: 10.1007/978-3-319-75765-0_3.Peer-Reviewed Original ResearchMelanin-concentrating hormoneLower vertebratesHigher animalsNeuropeptide melanin-concentrating hormonePhysiological functionsRole of MCHPhysiological implicationsCritical brain functionsHomeostatic functionsRegulation of sleepSleep/wake cycleRegulationLateral hypothalamusSleep promoterBrain circuitryNeuronal systemsBrain functionSleep homeostasisWake cycleMCH systemRecent evidenceNeural activityVertebratesAnimalsPromoter
2006
Adenosine Inhibits Activity of Hypocretin/Orexin Neurons by the A1 Receptor in the Lateral Hypothalamus: A Possible Sleep-Promoting Effect
Liu ZW, Gao XB. Adenosine Inhibits Activity of Hypocretin/Orexin Neurons by the A1 Receptor in the Lateral Hypothalamus: A Possible Sleep-Promoting Effect. Journal Of Neurophysiology 2006, 97: 837-848. PMID: 17093123, PMCID: PMC1783688, DOI: 10.1152/jn.00873.2006.Peer-Reviewed Original ResearchMeSH KeywordsAction PotentialsAdenosineAdenosine A1 Receptor AgonistsAnimalsArousalCalcium ChannelsDose-Response Relationship, DrugExcitatory Postsynaptic PotentialsGreen Fluorescent ProteinsHypothalamic Area, LateralImmunohistochemistryIntracellular Signaling Peptides and ProteinsMiceMice, TransgenicNeural InhibitionNeuronsNeuropeptidesOrexinsOrgan Culture TechniquesPertussis ToxinReceptor, Adenosine A1SleepSynaptic TransmissionConceptsHypocretin/orexin neuronsOrexin neuronsSleep-promoting effectsLateral hypothalamusBasal forebrainA1 receptorsMiniature excitatory postsynaptic currentsVoltage-dependent calcium currentsAdenosine-mediated inhibitionHypocretin/orexin systemExcitatory postsynaptic potentialsExcitatory synaptic transmissionExcitatory postsynaptic currentsEffects of adenosineHypocretin/orexinPostsynaptic currentsOrexin systemPostsynaptic potentialsCalcium currentSynaptic transmissionBrain slicesPertussis toxinSleep promoterAdenosine receptorsAction potentials