1991
The biosynthesis of endothelin-1 by human polymorphonuclear leukocytes
Sessa W, Kaw S, Hecker M, Vane J. The biosynthesis of endothelin-1 by human polymorphonuclear leukocytes. Biochemical And Biophysical Research Communications 1991, 174: 613-618. PMID: 1993057, DOI: 10.1016/0006-291x(91)91461-k.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsEndothelinsGlycopeptidesHumansIn Vitro TechniquesJugular VeinsKineticsLeucineMuscle, Smooth, VascularNeutrophilsN-Formylmethionine Leucyl-PhenylalaninePepstatinsPhenylmethylsulfonyl FluorideProtease InhibitorsRabbits
1990
Release of a neutrophil‐derived vascoconstrictor agent which augments platelet‐induced contractions of blood vessels in vitro
Sessa W, Mullane K. Release of a neutrophil‐derived vascoconstrictor agent which augments platelet‐induced contractions of blood vessels in vitro. British Journal Of Pharmacology 1990, 99: 553-559. PMID: 2110018, PMCID: PMC1917347, DOI: 10.1111/j.1476-5381.1990.tb12967.x.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAorta, ThoracicBlood PlateletsCalcimycinIn Vitro TechniquesLipoxygenase InhibitorsMaleMolecular WeightMuscle ContractionMuscle TonusMuscle, Smooth, VascularNeutrophilsN-Formylmethionine Leucyl-PhenylalanineRabbitsSerotoninSerotonin AntagonistsTetradecanoylphorbol AcetateVasoconstrictor AgentsConceptsContractile factorsVascular toneBlood vesselsEnd-organ antagonistNeutrophil-derived productsPlatelet-induced contractionsConcentration-dependent contractionsInhibition of contractionRat stomach stripCyclo-oxygenase enzymeTimes more plateletsRabbit thoracic aortaPhorbol myristate acetateFree radical scavengerContractile responseInhibitors of lipoxygenaseOrgan bathAngiotensin IIReceptor antagonistStomach stripIntact endotheliumNeutrophil activationThoracic aortaActivated neutrophilsDesArg9-bradykinin