2003
Mesenteric vasoconstriction is responsible for the initial eNOS upregulation in the superior mesenteric artery of portal hypertensive rats
Tsai M, Iwakiri Y, Cadelina G, Sessa W, Groszmann R. Mesenteric vasoconstriction is responsible for the initial eNOS upregulation in the superior mesenteric artery of portal hypertensive rats. Hepatology 2003, 38: 176-177. DOI: 10.1016/s0270-9139(03)80088-5.Peer-Reviewed Original Research
1999
NO overproduction by eNOS precedes hyperdynamic splanchnic circulation in portal hypertensive rats
Wiest R, Shah V, Sessa W, Groszmann R. NO overproduction by eNOS precedes hyperdynamic splanchnic circulation in portal hypertensive rats. American Journal Of Physiology 1999, 276: g1043-g1051. PMID: 10198349, DOI: 10.1152/ajpgi.1999.276.4.g1043.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBlood Flow VelocityBlood PressureEndothelium, VascularHypertension, PortalKineticsLuminescent MeasurementsMaleMesenteric Artery, SuperiorMethoxamineNitric OxideNitric Oxide SynthaseNitric Oxide Synthase Type IIINitroarginineRatsRats, Sprague-DawleySplanchnic CirculationStress, MechanicalConceptsHyperdynamic splanchnic circulationSuperior mesenteric arterySplanchnic circulationSham ratsNitric oxide synthase upregulationHyperdynamic circulatory syndromeNO metabolites concentrationPortal hypertensive ratsENOS protein levelsHigh blood flowSignificant hyporesponsivenessArterial vasodilatationL-NNAPortal hypertensionPVL ratsAgonist methoxamineCirculatory syndromeENOS upregulationHypertensive ratsMesenteric arteryNomega-nitroNO inhibitorBlood flowDay 3L-arginine
1990
Stz-Induced Diabetes in Shr and Renovascular Hypertensive Rats: Dissociation Between Changes in Arterial Pressure and Vascular Collagen Synthesis
Mariani M, Sessa W, Chichester C, Rodgers R. Stz-Induced Diabetes in Shr and Renovascular Hypertensive Rats: Dissociation Between Changes in Arterial Pressure and Vascular Collagen Synthesis. Clinical And Experimental Hypertension 1990, 12: 1003-1019. PMID: 2245511, DOI: 10.3109/10641969009073514.Peer-Reviewed Original ResearchConceptsRenovascular hypertensive ratsVascular collagen synthesisArterial pressureHypertensive ratsCollagen synthesisSTZ induced diabetesLeft renal arteryNormotensive WKY ratsSTZ-induced diabetesWistar-Kyoto ratsNondiabetic SHRRVH ratsRenovascular hypertensionWKY controlsNormotensive controlsRenal arteryWKY ratsProlyl hydroxylase activitySHRDiabetesRatsHydroxylase activityProline incorporationHypertensionWKY
1989
Manipulation of cytochrome P-450 dependent renal thromboxane synthase activity in spontaneously hypertensive rats
Sessa W, Abraham N, Escalante B, Schwartzman M. Manipulation of cytochrome P-450 dependent renal thromboxane synthase activity in spontaneously hypertensive rats. Journal Of Hypertension 1989, 7: 37-42. PMID: 2708811, DOI: 10.1097/00004872-198901000-00006.Peer-Reviewed Original ResearchConceptsHeme oxygenase activityThromboxane synthase activityHypertensive ratsRenal heme oxygenase activitySeven-week-old SHRRenal cortical microsomesSystolic blood pressureMicrosomal heme oxygenase activityRenal cytochrome PCytochrome PSynthase activityThromboxane A2 formationCortical microsomesBlood pressureOxygenase activityBody weightA2 formationHemoprotein synthesisConsecutive daysControl levelsThromboxane synthaseSHRRatsHeme contentHeme availability