Aberrant zonal recycling of germinal center B cells impairs appropriate selection in lupus
Sanchez G, Hirsch E, VanValkenburg A, Mayer D, Gbedande K, Francis R, Song W, Antao O, Brimmer K, Lemenze A, Stephens R, Johnson W, Weinstein J. Aberrant zonal recycling of germinal center B cells impairs appropriate selection in lupus. Cell Reports 2024, 43: 114978. PMID: 39527476, DOI: 10.1016/j.celrep.2024.114978.Peer-Reviewed Original ResearchGerminal centersB cellsDifferentiation of autoreactive B cellsLoss of MYCResponse to CD40 signalingPolyclonal B cell activationB cell dysregulationAccumulation of plasma cellsAutoreactive B cellsB cell activationGC B cellsB cell cycleProduction of autoantibodiesB cell signalingDecreased mutation frequencyRepertoire diversityPlasma cellsAutoimmune diseasesPersistent infectionCD40 signalingDisease progressionMutation frequencyReduced proliferationLupusLight zone