2024
T Follicular Helper Cell Heterogeneity
Song W, Craft J. T Follicular Helper Cell Heterogeneity. Annual Review Of Immunology 2024, 42: 127-152. PMID: 38060987, DOI: 10.1146/annurev-immunol-090222-102834.Peer-Reviewed Original ResearchTfh cellsHumoral immune memoryTfh cell subsetsFollicular helper cellsGerminal center responseCell subsetsHelper cellsHumoral immunityImmune memoryCenter responseCell responsesImmunoglobulin affinity maturationAffinity maturationCritical contributorCellsPublication dateClass switch recombinationImmunoglobulin class switch recombinationCell heterogeneity
2022
High-affinity, neutralizing antibodies to SARS-CoV-2 can be made without T follicular helper cells
Chen JS, Chow RD, Song E, Mao T, Israelow B, Kamath K, Bozekowski J, Haynes WA, Filler RB, Menasche BL, Wei J, Alfajaro MM, Song W, Peng L, Carter L, Weinstein JS, Gowthaman U, Chen S, Craft J, Shon JC, Iwasaki A, Wilen CB, Eisenbarth SC. High-affinity, neutralizing antibodies to SARS-CoV-2 can be made without T follicular helper cells. Science Immunology 2022, 7: eabl5652. PMID: 34914544, PMCID: PMC8977051, DOI: 10.1126/sciimmunol.abl5652.Peer-Reviewed Original ResearchConceptsSARS-CoV-2 infectionSARS-CoV-2Follicular helper cellsB cell responsesHelper cellsAntibody productionCell responsesSARS-CoV-2 vaccinationB-cell receptor sequencingSevere COVID-19Cell receptor sequencingIndependent antibodiesT cell-B cell interactionsViral inflammationAntiviral antibodiesImmunoglobulin class switchingVirus infectionGerminal centersViral infectionClonal repertoireInfectionAntibodiesClass switchingCOVID-19Patients