2024
Aberrant zonal recycling of germinal center B cells impairs appropriate selection in lupus
Sanchez G, Hirsch E, VanValkenburg A, Mayer D, Gbedande K, Francis R, Song W, Antao O, Brimmer K, Lemenze A, Stephens R, Johnson W, Weinstein J. Aberrant zonal recycling of germinal center B cells impairs appropriate selection in lupus. Cell Reports 2024, 43: 114978. PMID: 39527476, DOI: 10.1016/j.celrep.2024.114978.Peer-Reviewed Original ResearchGerminal centersB cellsDifferentiation of autoreactive B cellsLoss of MYCResponse to CD40 signalingPolyclonal B cell activationB cell dysregulationAccumulation of plasma cellsAutoreactive B cellsB cell activationGC B cellsB cell cycleProduction of autoantibodiesB cell signalingDecreased mutation frequencyRepertoire diversityPlasma cellsAutoimmune diseasesPersistent infectionCD40 signalingDisease progressionMutation frequencyReduced proliferationLupusLight zone
2023
The ion transporter Na+-K+-ATPase enables pathological B cell survival in the kidney microenvironment of lupus nephritis
Chernova I, Song W, Steach H, Hafez O, Al Souz J, Chen P, Chandra N, Cantley L, Veselits M, Clark M, Craft J. The ion transporter Na+-K+-ATPase enables pathological B cell survival in the kidney microenvironment of lupus nephritis. Science Advances 2023, 9: eadf8156. PMID: 36724234, PMCID: PMC9891690, DOI: 10.1126/sciadv.adf8156.Peer-Reviewed Original ResearchConceptsB cellsAutoimmune diseasesAmelioration of proteinuriaLupus nephritis biopsiesB cell infiltrationSodium-potassium adenosine triphosphataseB cell survivalPotassium adenosine triphosphataseLupus nephritisCell infiltrationKidney microenvironmentTissue injuryTherapeutic targetPharmacological inhibitionElevated sodium concentrationLupusHostile microenvironmentHigh expressionKidneySodium concentrationGenetic knockoutCell survivalDiseaseCellsAdenosine triphosphatase