2023
Can peripheral psychophysiological markers predict response to exposure-based cognitive behavioral therapy in youth with severely impairing irritability? A study protocol
Grasser L, Erjo T, Goodwin M, Naim R, German R, White J, Cullins L, Tseng W, Stoddard J, Brotman M. Can peripheral psychophysiological markers predict response to exposure-based cognitive behavioral therapy in youth with severely impairing irritability? A study protocol. BMC Psychiatry 2023, 23: 926. PMID: 38082431, PMCID: PMC10712194, DOI: 10.1186/s12888-023-05421-4.Peer-Reviewed Original ResearchConceptsExposure-based cognitive-behavioral therapyCognitive behavioral therapyPhysiological arousalBehavioral therapyAffective Reactivity IndexMultiple baseline trialClinical Global Impression ScaleAnger-inducing stimuliPeripheral physiological indicatorsIndividual differencesPsychophysiological markersPerson changesExposure sessionsMultilevel modelingPsychophysiological indicatorsHR/HRVInitial evidenceMental healthReasons youthReactivity indexYouthAppropriate Institutional Review BoardTreatment mechanismsGlobal Impression ScaleCourse of treatment
2021
Functional connectivity during frustration: a preliminary study of predictive modeling of irritability in youth
Scheinost D, Dadashkarimi J, Finn ES, Wambach CG, MacGillivray C, Roule AL, Niendam TA, Pine DS, Brotman MA, Leibenluft E, Tseng WL. Functional connectivity during frustration: a preliminary study of predictive modeling of irritability in youth. Neuropsychopharmacology 2021, 46: 1300-1306. PMID: 33479511, PMCID: PMC8134471, DOI: 10.1038/s41386-020-00954-8.Peer-Reviewed Original ResearchConceptsFunctional connectivityAttention-deficit/hyperactivity disorderCognitive flexibility taskDisruptive mood dysregulation disorderAffective Reactivity IndexLevels of irritabilityPreliminary fMRI studyCognitive flexibilityFlexibility taskIndividual differencesTransdiagnostic sampleFrontal networkFMRI studyHyperactivity disorderTask difficultyNeural mechanismsParent reportAnxiety symptomsSalience networkAnxiety disordersFrustrative nonrewardDimensional measuresPreliminary evidenceReactivity indexChild psychiatry