1992
Adjunctive therapy in bacterial meningitis--what make sense?
Quagliarello V, Scheld W. Adjunctive therapy in bacterial meningitis--what make sense? Infectious Agents And Disease 1992, 1: 167-71. PMID: 1365542.Peer-Reviewed Original ResearchConceptsAdjunctive therapyBacterial meningitisCerebrospinal fluidAdjunctive corticosteroidsNeurologic outcomeCSF inflammationAntibiotic therapyBrain edemaCerebral microvasculatureInflammatory cytokinesTherapyMeningitisInflammationPathophysiologyChildrenCorticosteroidsMorbidityEdemaCytokinesMortalityMicrovasculature
1991
Ultrastructural localization of albumin transport across the cerebral microvasculature during experimental meningitis in the rat.
Quagliarello V, Ma A, Stukenbrok H, Palade G. Ultrastructural localization of albumin transport across the cerebral microvasculature during experimental meningitis in the rat. Journal Of Experimental Medicine 1991, 174: 657-672. PMID: 1875166, PMCID: PMC2118932, DOI: 10.1084/jem.174.3.657.Peer-Reviewed Original ResearchConceptsBlood-brain barrierBBB injuryExperimental meningitisCerebral microvasculatureOpen intercellular junctionsSpecific therapeutic interventionsBacterial meningitisBrain barrierIntracisternal inoculationMeningitisBrain cortexInjury mechanismMicrovascular segmentsTherapeutic interventionsIntercellular junctionsInducible increaseAu-BSAInjuryAbluminal sidePrecise mechanismSimilar uptakeAlbumin transportColloidal carbonTracer perfusionVenular leaks