2021
Association of Race and Ethnicity with Sedation Management in Pediatric Intensive Care.
Natale J, Asaro L, Joseph J, Ulysse C, Ascenzi J, Bowens C, Wypij D, Curley M, Curley M, Wypij D, Allen G, Angus D, Asaro L, Ascenzi J, Bateman S, Borasino S, Bowens C, Bysani G, Cheifetz I, Cowl A, Dodson B, Faustino E, Fineman L, Flori H, Franck L, Gedeit R, Grant M, Harabin A, Haskins-Kiefer C, Hertzog J, Hutchins L, Kirby A, Lebet R, Matthay M, McLaughlin G, Natale J, Oren P, Polavarapu N, Schneider J, Schwarz A, Shanley T, Simone S, Singer L, Sorce L, Truemper E, Vander Heyden M, Watson R, Wells C. Association of Race and Ethnicity with Sedation Management in Pediatric Intensive Care. Annals Of The American Thoracic Society 2021, 18: 93-102. PMID: 32776853, PMCID: PMC7780975, DOI: 10.1513/annalsats.201912-872oc.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentBlack PeopleChildChild, PreschoolCritical CareEthnicityFemaleHealthcare DisparitiesHispanic or LatinoHumansInfantInfant, NewbornIntensive Care Units, PediatricMaleMulticenter Studies as TopicPainPain ManagementRandomized Controlled Trials as TopicRespiration, ArtificialRespiratory InsufficiencyWhite PeopleConceptsSedation managementPain managementClinical trialsU.S. pediatric intensive care unitsPediatric intensive care unitCluster-randomized clinical trialRacial disparitiesIatrogenic withdrawal syndromeAcute respiratory failureEpisodes of painPlanned secondary analysisIntensive care unitPediatric intensive careAssociation of raceEthnicity groupsNon-Hispanic blacksPercentage of daysRespiratory failureUsual careCumulative dosingPediatric patientsWithdrawal syndromeBlack patientsCare unitIntervention arm
2020
Surfactant Protein D Is Associated With Severe Pediatric ARDS, Prolonged Ventilation, and Death in Children With Acute Respiratory Failure
Dahmer M, Flori H, Sapru A, Kohne J, Weeks H, Curley M, Matthay M, Quasney M, Network B, Bateman S, Berg M, Borasino S, Bysani G, Cowl A, Bowens C, Faustino E, Fineman L, Godshall A, Hirshberg E, Kirby A, McLaughlin G, Medar S, Oren P, Schneider J, Schwarz A, Shanley T, Sorce L, Truemper E, Vander Heyden M, Wittmayer K, Zuppa A, Wypij D. Surfactant Protein D Is Associated With Severe Pediatric ARDS, Prolonged Ventilation, and Death in Children With Acute Respiratory Failure. CHEST Journal 2020, 158: 1027-1035. PMID: 32275979, PMCID: PMC7478231, DOI: 10.1016/j.chest.2020.03.041.Peer-Reviewed Original ResearchConceptsAcute respiratory failureSP-D levelsPediatric ARDSRespiratory failureLung injurySurfactant protein DPlasma SPPrimary diagnosisPlasma SP-D levelsHigher oxygenation indexProtein DDays of intubationProspective cohort studyChronic lung diseaseRespiratory distress syndromeMulti-center studyYears of ageEnzyme-linked immunosorbentPediatric RiskPICU lengthOxygenation indexProlonged ventilationCohort studyMortality IIIDistress syndrome50 Years Ago in T he J ournal of P ediatrics Thromboses Due to Catheterization in Infants and Children
Kandil S, Faustino EV. 50 Years Ago in T he J ournal of P ediatrics Thromboses Due to Catheterization in Infants and Children. The Journal Of Pediatrics 2020, 216: 100. PMID: 31843106, DOI: 10.1016/j.jpeds.2019.07.067.Peer-Reviewed Original Research
2018
Sedation Management for Critically Ill Children with Pre-Existing Cognitive Impairment
Best K, Asaro L, Curley M, Investigators R, Wypij D, Allen G, Angus D, Ascenzi J, Bateman S, Borasino S, Bowens C, Bysani G, Cheifetz I, Cowl A, Dodson B, Faustino E, Fineman L, Flori H, Franck L, Gedeit R, Grant M, Harabin A, Haskins-Kiefer C, Hertzog J, Hutchins L, Kirby A, Lebet R, Matthay M, McLaughlin G, Natale J, Oren P, Polavarapu N, Schneider J, Schwarz A, Shanley T, Simone S, Singer L, Sorce L, Truemper E, Vander Heyden M, Watson R, Wells C. Sedation Management for Critically Ill Children with Pre-Existing Cognitive Impairment. The Journal Of Pediatrics 2018, 206: 204-211.e1. PMID: 30527750, PMCID: PMC6389364, DOI: 10.1016/j.jpeds.2018.10.042.Peer-Reviewed Original ResearchConceptsPediatric intensive care unitIntensive care unitCognitive impairmentSedation managementCare unitIll childrenStudy daysSevere pediatric acute respiratory distress syndromePediatric acute respiratory distress syndromePediatric Cerebral Performance CategoryAcute respiratory distress syndromePre-existing cognitive impairmentSedation management practicesAcute respiratory failureCerebral Performance CategoryEpisodes of painDevelopment of painRespiratory distress syndromeSedation assessment toolsIatrogenic withdrawal symptomsNeurotypical subjectsMore study daysAssessment toolSedative requirementsRespiratory failure
2017
Racial and Ethnic Disparities in Parental Refusal of Consent in a Large, Multisite Pediatric Critical Care Clinical Trial
Natale J, Lebet R, Joseph J, Ulysse C, Ascenzi J, Wypij D, Curley M, Investigators R, Curley M, Wypij D, Allen G, Angus D, Asaro L, Ascenzi J, Bateman S, Borasino S, Bowens C, Bysani G, Cheifetz I, Cowl A, Dodson B, Faustino E, Fineman L, Flori H, Franck L, Gedeit R, Grant M, Harabin A, Haskins-Kiefer C, Hertzog J, Hutchins L, Kirby A, Lebet R, Matthay M, McLaughlin G, Natale J, Oren P, Polavarapu N, Schneider J, Schwarz A, Shanley T, Simone S, Singer L, Sorce L, Truemper E, Vander Heyden M, Watson R, Wells C. Racial and Ethnic Disparities in Parental Refusal of Consent in a Large, Multisite Pediatric Critical Care Clinical Trial. The Journal Of Pediatrics 2017, 184: 204-208.e1. PMID: 28410087, DOI: 10.1016/j.jpeds.2017.02.006.Peer-Reviewed Original ResearchConceptsCritical care clinical trialsCare clinical trialsRespiratory failureClinical trialsParental refusalHispanic childrenAcute respiratory failureMultivariable logistic regressionWhite childrenNon-Hispanic blacksNon-Hispanic whitesRace/ethnicitySedation TitrationSedation managementIntervention armMechanical ventilationParents of childrenEnrollment criteriaPatient raceControl armIll childrenStudy consentEthnic disparitiesSecondary analysisRandomized EvaluationTight Glycemic Control in Critically Ill Children
Agus M, Wypij D, Hirshberg E, Srinivasan V, Faustino E, Luckett P, Alexander J, Asaro L, Curley M, Steil G, Nadkarni V. Tight Glycemic Control in Critically Ill Children. New England Journal Of Medicine 2017, 376: 729-741. PMID: 28118549, PMCID: PMC5444653, DOI: 10.1056/nejmoa1612348.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentBlood GlucoseCardiovascular Surgical ProceduresChildChild, PreschoolCritical IllnessFemaleGlucoseHospital MortalityHumansHyperglycemiaHypoglycemic AgentsInfantInfant, NewbornInsulinIntensive Care Units, PediatricIntention to Treat AnalysisLength of StayMalePostoperative PeriodConceptsHigher-target groupLower-target groupTight glycemic controlBlood glucose levelsGlycemic controlIll childrenGlucose levelsCardiac surgeryHealth care-associated infectionsICU-free daysVentilator-free daysCritically Ill ChildrenNormal blood glucose levelsIntensive care unitCare-associated infectionsSafety monitoring boardAverage glucose levelsHigh rateContinuous glucose monitoringIll adultsOrgan dysfunctionPrimary outcomeSevere hypoglycemiaTreat analysisCare unit