2024
Presence of Mood and/or Anxiety Disorders Does Not Affect Success of Weight Management Therapies in Metabolic Dysfunction-Associated Steatotic Liver Disease
Bollinger B, Cotter R, Deng Y, Ilagan-Ying Y, Gupta V. Presence of Mood and/or Anxiety Disorders Does Not Affect Success of Weight Management Therapies in Metabolic Dysfunction-Associated Steatotic Liver Disease. Digestive Diseases And Sciences 2024, 1-8. PMID: 39604664, DOI: 10.1007/s10620-024-08724-y.Peer-Reviewed Original ResearchTotal body weight lossBody weight lossPhentermine-topiramateBariatric surgeryHepatology practiceWeight lossAnxiety disordersLiver diseaseSteatotic liver diseaseFIB-4 scorePredictors of weight lossPresence of psychiatric diseaseRetrospective cohort studyMultivariate logistic regression modelWeight management therapySignificant predictorsHepatic outcomesFIB-4Logistic regression modelsCohort studyICD-10 diagnosisPatient populationPresence of moodPrimary outcomeSecondary outcomes
2021
Cell and Tissue Therapy for the Treatment of Chronic Liver Disease
Bram Y, Nguyen DT, Gupta V, Park J, Richardson C, Chandar V, Schwartz RE. Cell and Tissue Therapy for the Treatment of Chronic Liver Disease. Annual Review Of Biomedical Engineering 2021, 23: 1-30. PMID: 33974812, PMCID: PMC8864721, DOI: 10.1146/annurev-bioeng-112619-044026.Peer-Reviewed Original ResearchConceptsLiver diseaseLiver transplantationOrgan transplantationNonalcoholic fatty liver diseaseTissue-based therapiesChronic liver diseaseFatty liver diseaseSolid organ transplantationCommon solid organ transplantationImportant clinical problemCause of deathLiver failureRisk factorsClinical problemAvailable organsTransplantationTherapyDiseaseGold standardRegenerative therapyTissue therapyTreatmentCellsSteatohepatitisMorbidity
2020
Hedgehog Signaling Demarcates a Niche of Fibrogenic Peribiliary Mesenchymal Cells
Gupta V, Gupta I, Park J, Bram Y, Schwartz RE. Hedgehog Signaling Demarcates a Niche of Fibrogenic Peribiliary Mesenchymal Cells. Gastroenterology 2020, 159: 624-638.e9. PMID: 32289375, PMCID: PMC8204800, DOI: 10.1053/j.gastro.2020.03.075.Peer-Reviewed Original ResearchConceptsCholestatic injuryStellate cellsLiver tissueStromal cellsLiver diseaseBile ductBiliary treePortal tractsMesenchymal cellsPrimary sclerosing cholangitisAlcoholic liver diseaseEpithelial cellsMyofibroblast phenotypeQuantitative reverse transcription polymerase chain reactionBile duct ligationReverse transcription-polymerase chain reactionTranscription-polymerase chain reactionCanals of HeringControl liver tissueHedgehog signalingSclerosing cholangitisHepatic injuryHepatocellular injuryNonalcoholic steatohepatitisPortal fibroblasts