2022
Adipocyte plasticity in tissue regeneration, repair, and disease
Horsley V. Adipocyte plasticity in tissue regeneration, repair, and disease. Current Opinion In Genetics & Development 2022, 76: 101968. PMID: 35988318, DOI: 10.1016/j.gde.2022.101968.Peer-Reviewed Original ResearchMeSH KeywordsAdipocytesAdipokinesAnimalsFibrosisHumansLipidsMammalsRegenerative MedicineWound HealingConceptsMammalian tissue repairTissue repairEssential regulatorAdipocyte plasticityFunction of adipocytesCritical regulatorLipid-filled cellsMultiple tissuesTissue functionRegenerative medicineAdipocytesSkeletal muscleBioactive productsRegulatorMammary glandTherapeutic avenuesFibrotic lesionsEndocrine functionTissue regenerationPlasticityWound healingContractile fibroblastsTissueRepairTumorigenesis
2021
Skin Fibrosis and Recovery Is Dependent on Wnt Activation via DPP4
Jussila AR, Zhang B, Caves E, Kirti S, Steele M, Hamburg-Shields E, Lydon J, Ying Y, Lafyatis R, Rajagopalan S, Horsley V, Atit RP. Skin Fibrosis and Recovery Is Dependent on Wnt Activation via DPP4. Journal Of Investigative Dermatology 2021, 142: 1597-1606.e9. PMID: 34808238, PMCID: PMC9120259, DOI: 10.1016/j.jid.2021.10.025.Peer-Reviewed Original ResearchConceptsWnt/β-catenin-responsive geneWnt activationExtracellular matrix homeostasisGenetic evidenceHuman fibrotic diseasesLipid-filled cellsFunctional mediatorsExtracellular matrixDermal adipocytesMatrix homeostasisGenetic modelsNew targetsWntKey targetMechanisms of fibrosisFibrotic diseasesTherapeutic avenuesDermal remodelingExtracellular matrix expansionExcessive accumulationRemodelingFibrosis severitySkin fibrosisFibrotic remodelingDPP4 inhibitors
2019
Thin Skinned: Aged Adipocyte Atrophy Impacts Innate Immunity
Wasko RR, Horsley V. Thin Skinned: Aged Adipocyte Atrophy Impacts Innate Immunity. Trends In Immunology 2019, 40: 175-177. PMID: 30713009, DOI: 10.1016/j.it.2019.01.009.Peer-Reviewed Original Research
2018
Myofibroblast proliferation and heterogeneity are supported by macrophages during skin repair
Shook BA, Wasko RR, Rivera-Gonzalez GC, Salazar-Gatzimas E, López-Giráldez F, Dash BC, Muñoz-Rojas AR, Aultman KD, Zwick RK, Lei V, Arbiser JL, Miller-Jensen K, Clark DA, Hsia HC, Horsley V. Myofibroblast proliferation and heterogeneity are supported by macrophages during skin repair. Science 2018, 362 PMID: 30467144, PMCID: PMC6684198, DOI: 10.1126/science.aar2971.Peer-Reviewed Original ResearchConceptsDifferential gene expressionAdipocyte precursorsExtracellular matrix moleculesGene expressionTransplantation assaysMatrix moleculesFactor C.Factor 1Insulin-like growth factor-1Cell populationsTissue resilienceDistinct subpopulationsGrowth factor-1Profibrotic cellsTissue repairMultiple mouse modelsECM depositionSkin repairTissue dysfunctionProliferationMouse modelMyofibroblastsWoundingMacrophagesRepair
2015
Origin of fibrosing cells in systemic sclerosis
Ebmeier S, Horsley V. Origin of fibrosing cells in systemic sclerosis. Current Opinion In Rheumatology 2015, 27: 555-562. PMID: 26352735, PMCID: PMC4639394, DOI: 10.1097/bor.0000000000000217.Peer-Reviewed Original ResearchConceptsSystemic sclerosisEndothelial cellsInjury-induced fibrosisEpithelial cellsProgressive fibrosisAutoimmune diseasesTreatment optionsEffective therapyInjury modelFibrosis modelChronic natureAnimal modelsTissue stromaSclerosisCell originFibrosisUnknown originVariety of tissuesCellular originRecent evidenceFibrocytesDiseasePericytesSpecific organsAdipocytes