2015
Nuclear–cytoskeletal linkages facilitate cross talk between the nucleus and intercellular adhesions
Stewart RM, Zubek AE, Rosowski KA, Schreiner SM, Horsley V, King MC. Nuclear–cytoskeletal linkages facilitate cross talk between the nucleus and intercellular adhesions. Journal Of Cell Biology 2015, 209: 403-418. PMID: 25963820, PMCID: PMC4427780, DOI: 10.1083/jcb.201502024.Peer-Reviewed Original ResearchConceptsIntercellular adhesionNuclear positionEpidermal tissue integrityLinker of nucleoskeletonCross talkPrimary mouse keratinocytesCytoskeleton (LINC) complexCytoplasmic cytoskeletonAdhesion functionMicrotubule networkDefective adhesionCytoskeletonSUN2Mouse keratinocytesTissue integrityFollicle structureEpidermal keratinocytesAdhesionNucleoskeletonCellsKeratinocytesAdhesion formationNucleusIntegrityComplexes
2008
NFATc1 Balances Quiescence and Proliferation of Skin Stem Cells
Horsley V, Aliprantis AO, Polak L, Glimcher LH, Fuchs E. NFATc1 Balances Quiescence and Proliferation of Skin Stem Cells. Cell 2008, 132: 299-310. PMID: 18243104, PMCID: PMC2546702, DOI: 10.1016/j.cell.2007.11.047.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntigens, CD34BiomarkersCell NucleusCell ProliferationCells, CulturedCyclin-Dependent Kinase 4CyclosporineDown-RegulationEmbryo, MammalianGene DeletionGene ExpressionGene Expression Regulation, DevelopmentalGenes, ReporterHair FollicleImmunohistochemistryImmunosuppressive AgentsMiceMice, KnockoutMice, NudeMorphogenesisNFATC Transcription FactorsRetroviridaeRNA, MessengerSkinSkin TransplantationStem CellsTranscription FactorsTransgenesTransplantation, HomologousConceptsStem cellsHair growthCell quiescenceStem cell quiescenceExcessive hair growthFollicular growthNFATc1 signalingHair follicle stem cellsFollicle stem cellsGene ablationQuiescent adult stem cellsAdult stem cellsNFATc1Skin stem cellsFunctional roleCellsTissue homeostasisProliferationPatientsInjury