2018
Anatomical, Physiological, and Functional Diversity of Adipose Tissue
Zwick RK, Guerrero-Juarez CF, Horsley V, Plikus MV. Anatomical, Physiological, and Functional Diversity of Adipose Tissue. Cell Metabolism 2018, 27: 68-83. PMID: 29320711, PMCID: PMC6050204, DOI: 10.1016/j.cmet.2017.12.002.Peer-Reviewed Original ResearchConceptsStem cell quiescenceInnate immune barrierNon-traditional functionsFunctional diversityEpithelial stem cell quiescenceMammary glandCell quiescenceOrgan regenerationAdipocyte progenitorsHair folliclesNeighboring cellsMetabolic functionsRange of cancersNovel therapeutic approachesAdipose tissue depotsBacterial invasionAdipocytesProgenitorsAutoimmune disordersImmune barrierTherapeutic approachesClose associationAdipose tissueBone marrowTissue depots
2014
Defining dermal adipose tissue
Driskell RR, Jahoda CA, Chuong C, Watt FM, Horsley V. Defining dermal adipose tissue. Experimental Dermatology 2014, 23: 629-631. PMID: 24841073, PMCID: PMC4282701, DOI: 10.1111/exd.12450.Peer-Reviewed Original ResearchConceptsDevelopment of adipocytesSubcutaneous adipose tissue developmentHair follicle regenerationAdipose tissue developmentDermal adipose tissueTissue developmentEpidermal homeostasisLipid-filled cellsFollicle regenerationCommon precursorRole of adipocytesAdipocytesAdipose tissueDermal fibroblastsDermal white adipose tissueWhite adipose tissueHair folliclesSubcutaneous adiposeInvertebratesCellsTissueRecent dataSpeciesHomeostasisHypodermisDeveloping stratified epithelia: lessons from the epidermis and thymus
Roberts N, Horsley V. Developing stratified epithelia: lessons from the epidermis and thymus. WIREs Mechanisms Of Disease 2014, 3: 389-402. PMID: 25176390, PMCID: PMC4283209, DOI: 10.1002/wdev.146.Peer-Reviewed Original ResearchConceptsSelf-restricted T cellsSkin epidermisNumber of organsSquamous epithelial cellsThymic epitheliumT cellsForeign pathogensMulti-layered epitheliumHair folliclesProgenitor cellsEpithelial cellsThymusEpithelial differentiation programEpitheliumStratified epitheliumEpithelial tissuesMolecular mechanismsEpidermisDifferentiation programTissueCellsNegative selectionEmbryonic germ layers
2012
Unravelling hair follicle–adipocyte communication
Schmidt B, Horsley V. Unravelling hair follicle–adipocyte communication. Experimental Dermatology 2012, 21: 827-830. PMID: 23163647, PMCID: PMC3507425, DOI: 10.1111/exd.12001.Peer-Reviewed Original ResearchHome sweet home: skin stem cell niches
Goldstein J, Horsley V. Home sweet home: skin stem cell niches. Cellular And Molecular Life Sciences 2012, 69: 2573-2582. PMID: 22410738, PMCID: PMC3449145, DOI: 10.1007/s00018-012-0943-3.Peer-Reviewed Original Research
2008
More than one way to skin . . .
Fuchs E, Horsley V. More than one way to skin . . . Genes & Development 2008, 22: 976-985. PMID: 18413712, PMCID: PMC2732395, DOI: 10.1101/gad.1645908.Peer-Reviewed Original ResearchConceptsStem cellsMultiple signaling networksNormal tissue homeostasisStem cell nicheStem cell populationResident stem cellsEpithelial-mesenchymal interactionsCell populationsCell fateSignaling networksSpecific lineagesTissue homeostasisCell nicheEpithelial stem cellsEpithelial lineageRecent cluesNormal homeostasisEpithelial tissuesLineagesWound repairHomeostasisCellsHair folliclesNicheFate
2006
Blimp1 Defines a Progenitor Population that Governs Cellular Input to the Sebaceous Gland
Horsley V, O'Carroll D, Tooze R, Ohinata Y, Saitou M, Obukhanych T, Nussenzweig M, Tarakhovsky A, Fuchs E. Blimp1 Defines a Progenitor Population that Governs Cellular Input to the Sebaceous Gland. Cell 2006, 126: 597-609. PMID: 16901790, PMCID: PMC2424190, DOI: 10.1016/j.cell.2006.06.048.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAnimals, NewbornBromodeoxyuridineCell CountCell DifferentiationCell LineageCell MovementCell ProliferationCells, CulturedEpithelial CellsGene Expression Regulation, DevelopmentalHair FollicleHyperplasiaMiceMice, KnockoutMice, TransgenicMultipotent Stem CellsPositive Regulatory Domain I-Binding Factor 1Proto-Oncogene Proteins c-mycRepressor ProteinsSebaceous GlandsStem CellsTranscription FactorsConceptsMultipotent stem cellsCellular inputsGenetic lineage tracingStem cellsUnipotent progenitor cellsTranscriptional repressor Blimp1Stem cell activityElevated c-myc expressionLineage commitmentC-myc expressionBrdU-labeling experimentsLineage tracingProgenitor populationsLineagesBlimp1Progenitor cellsCell proliferationLabeling experimentsSebaceous glandsCellsCell culture studiesSG homeostasisHair folliclesHomeostasisGland