2023
Cervical Pessary for Prevention of Preterm Birth in Individuals With a Short Cervix
Hoffman M, Clifton R, Biggio J, Saade G, Ugwu L, Longo M, Bousleiman S, Clark K, Grobman W, Frey H, Chauhan S, Dugoff L, Manuck T, Chien E, Rouse D, Simhan H, Esplin M, Macones G, Bickus M, Facco F, Tita A, Grant J, Casey B, Harris S, Harper L, Dunn D, Longo S, Hendricks M, Lata-Arias K, Costantine M, Bartholomew A, Cline D, Harper S, Ward C, Gardner N, Brindle S, Weigand S, McKenna D, Snow E, Fennig K, Habli M, Lambers D, McClellan M, Metz T, Sowles A, Varner M, Hill K, Morby V, Meadows C, Allard D, Werner E, Rousseau J, Milano J, Pettker C, Leventhal J, Gyamfi-Bannerman C, Wapner R, Carmona V, Firman B, Vanneman A, Palomares K, Beche I, Skupski D, Chan-Akeley R, Salazar A, Pacheco L, McCoy L, Saad A, Jain S, Omere C, Clifford C, McDonnold M, Chien E, Dalton W, Polito L, Milluzi C, Kushner K, Maile A, Bell J, Hackney D, Ortiz F, Timlin S, Goodnight W, Manuck T, Beamon C, Nun H, Eichelberger K, Moore A, Hughes B, Ferrara J, Grobman W, Mallett G, Stein L, Miller E, Plunkett B, Kearns K, Palatnik A, Malone T, Parry S, Pizzi C, Craig J, Filipczak A, Thom E, Doherty L, Hubbard A, Erikson P, Pinto T, Marcharchand P, Reddy U, Miodovnik M, Archer S. Cervical Pessary for Prevention of Preterm Birth in Individuals With a Short Cervix. JAMA 2023, 330: 340-348. PMID: 37490086, PMCID: PMC10369212, DOI: 10.1001/jama.2023.10812.Peer-Reviewed Original ResearchConceptsCervical pessaryUsual carePreterm birthShort cervixVaginal progesteroneCervical lengthSingleton pregnanciesFetal deathPrimary outcomeInfant deathPrior spontaneous preterm birthTransvaginal ultrasound cervical lengthCervical pessary placementWeeks 0 daysSpontaneous preterm birthUltrasound cervical lengthWeeks 6 daysThird interim analysisNeonatal/infant mortalityPreterm deliverySingleton gestationsBaseline characteristicsUltrasound evidencePessary placementTransvaginal ultrasound
2021
Chronic hypertension, perinatal mortality and the impact of preterm delivery: a population‐based study
Grover S, Brandt J, Reddy U, Ananth C. Chronic hypertension, perinatal mortality and the impact of preterm delivery: a population‐based study. BJOG An International Journal Of Obstetrics & Gynaecology 2021, 129: 572-579. PMID: 34536318, PMCID: PMC9214277, DOI: 10.1111/1471-0528.16932.Peer-Reviewed Original ResearchConceptsPerinatal mortality rateChronic hypertensionEarly term deliveryPreterm deliveryPerinatal mortalityMortality rateTerm deliverySingleton birthsCausal mediation analysisMaternal chronic hypertensionElevated blood pressureModifiable risk factorsPopulation-based studyWeeks of gestationLate-term gestationCross-sectional analysisNormotensive pregnanciesPreterm birthBlood pressureTerm gestationPerinatal deathRisk factorsHypertensionMAIN OUTCOMEMortalityOutcomes in Twins Compared With Singletons Subsequent to Preterm Prelabor Rupture of Membranes
Bartal M, Ugwu LG, Grobman WA, Bailit JL, Reddy UM, Wapner RJ, Varner MW, Thorp JM, Caritis SN, Prasad M, Tita ATN, Saade GR, Rouse DJ. Outcomes in Twins Compared With Singletons Subsequent to Preterm Prelabor Rupture of Membranes. Obstetrics And Gynecology 2021, 138: 725-731. PMID: 34619719, PMCID: PMC8542618, DOI: 10.1097/aog.0000000000004561.Peer-Reviewed Original ResearchMeSH KeywordsAdultChorioamnionitisCohort StudiesEndometritisEnterocolitis, NecrotizingFemaleFetal Membranes, Premature RuptureGestational AgeHumansInfant, NewbornInfant, PrematureOutcome Assessment, Health CarePerinatal MortalityPregnancyPregnancy OutcomePregnancy, TwinPremature BirthSepsisVenous ThromboembolismWound InfectionYoung AdultConceptsComposite maternal morbidityPreterm prelabor ruptureWeeks of gestationNeonatal morbidityPreterm PROMSingleton gestationsMaternal morbidityPrelabor ruptureTwin gestationsOdds ratioComposite major neonatal morbidityComposite neonatal morbidityMajor neonatal morbidityMedian gestational ageMedian latency periodMajor fetal anomaliesAdjusted odds ratioCoprimary outcomesObstetric cohortNeonatal outcomesTwin neonatesGestational agePotential confoundersFetal anomaliesMorbidity
2019
Severe maternal morbidity during delivery hospitalisation in a large international administrative database, 2008–2013: a retrospective cohort
Lipkind H, Zuckerwise L, Turner E, Collins J, Campbell K, Reddy U, Illuzi J, Merriam A. Severe maternal morbidity during delivery hospitalisation in a large international administrative database, 2008–2013: a retrospective cohort. BJOG An International Journal Of Obstetrics & Gynaecology 2019, 126: 1223-1230. PMID: 31100201, DOI: 10.1111/1471-0528.15818.Peer-Reviewed Original ResearchMeSH KeywordsAdultAustraliaCenters for Disease Control and Prevention, U.S.ComorbidityDatabases, FactualEnglandFemaleHospitalizationHumansMaternal AgeMaternal DeathMiddle AgedObstetric Labor ComplicationsPregnancyPregnancy ComplicationsPregnancy OutcomeRetrospective StudiesRisk FactorsUnited StatesYoung AdultConceptsSevere maternal morbidityMaternal morbidityDelivery hospitalisationRetrospective cohortRisk factorsSevere maternal morbidity ratesMaternal morbidity ratesAcute renal failureLife-threatening diagnosisAdvanced maternal ageLife-saving procedureLarge university hospitalChi-square testMorbidity variesPregnancy complicationsClinical characteristicsIntravascular coagulationRenal failureSevere morbidityMultivariable analysisMorbidity rateAdverse outcomesClinical differencesMaternal ageUniversity Hospital
2018
Cervical funneling or intra‐amniotic debris and preterm birth in nulliparous women with midtrimester cervical length less than 30 mm
Saade G, Thom E, Grobman W, Iams J, Mercer B, Reddy U, Tita A, Rouse D, Sorokin Y, Wapner R, Leveno K, Blackwell S, Esplin M, Tolosa J, Thorp J, Caritis S, Vandorsten J, Network T. Cervical funneling or intra‐amniotic debris and preterm birth in nulliparous women with midtrimester cervical length less than 30 mm. Ultrasound In Obstetrics And Gynecology 2018, 52: 757-762. PMID: 29155504, PMCID: PMC5960623, DOI: 10.1002/uog.18960.Peer-Reviewed Original ResearchConceptsCervical funnelingMidtrimester cervical lengthCervical lengthPreterm birthWeeks' gestationNulliparous womenMedian cervical lengthSecondary cohort analysisNulliparous pregnant womenSecond trimester ultrasoundAsymptomatic nulliparous womenMultivariable adjustmentSingleton gestationsMulticenter trialMultivariable analysisTransvaginal ultrasoundSecond trimesterPregnant womenCohort analysisGestationWomenHigh rateWeeksUltrasoundLtPotentially Preventable Stillbirth in a Diverse U.S. Cohort
Page JM, Thorsten V, Reddy UM, Dudley DJ, Hogue CJR, Saade GR, Pinar H, Parker CB, Conway D, Stoll BJ, Coustan D, Bukowski R, Varner MW, Goldenberg RL, Gibbins K, Silver RM. Potentially Preventable Stillbirth in a Diverse U.S. Cohort. Obstetrics And Gynecology 2018, 131: 336-343. PMID: 29324601, PMCID: PMC5785410, DOI: 10.1097/aog.0000000000002421.Peer-Reviewed Original ResearchConceptsStillbirth Collaborative Research NetworkPreventable stillbirthsPlacental insufficiencyHypertensive disordersMultiple gestationsMedical complicationsPopulation-based case-control studyDiverse U.S. cohortSpontaneous preterm birthMedical record abstractionWeeks of gestationCases of stillbirthCase-control studyCollaborative research networksResearch NetworkStillbirth reductionPreterm laborPreterm birthPlacental pathologyRecord abstractionNonanomalous fetusesMaternal interviewsPostmortem examinationU.S. cohortStillbirth
2016
Stillbirth, hypertensive disorders of pregnancy, and placental pathology
Gibbins KJ, Silver RM, Pinar H, Reddy UM, Parker CB, Thorsten V, Willinger M, Dudley DJ, Bukowski R, Saade GR, Koch MA, Conway D, Hogue CJ, Stoll BJ, Goldenberg RL. Stillbirth, hypertensive disorders of pregnancy, and placental pathology. Placenta 2016, 43: 61-68. PMID: 27324101, PMCID: PMC5893308, DOI: 10.1016/j.placenta.2016.04.020.Peer-Reviewed Original ResearchConceptsPlacental pathologyParenchymal infarctionLive birthsPreterm stillbirthSimilar clinical risk factorsStillbirth Collaborative Research NetworkPopulation-based cohort studyFetal vascular lesionsClinical risk factorsFeto-placental ratioGestational hypertensionRetroplacental hematomaHypertensive disordersCohort studyPlacental lesionsVascular lesionsAvascular villiFibrin depositionRisk factorsVascular thrombiStillbirthPregnancySecondary analysisInfarctionGH
2015
Predictors of response to 17-alpha hydroxyprogesterone caproate for prevention of recurrent spontaneous preterm birth
Manuck TA, Esplin MS, Biggio J, Bukowski R, Parry S, Zhang H, Huang H, Varner MW, Andrews W, Saade G, Sadovsky Y, Reddy UM, Ilekis J, Research E. Predictors of response to 17-alpha hydroxyprogesterone caproate for prevention of recurrent spontaneous preterm birth. American Journal Of Obstetrics And Gynecology 2015, 214: 376.e1-376.e8. PMID: 26692181, PMCID: PMC4803498, DOI: 10.1016/j.ajog.2015.12.010.Peer-Reviewed Original ResearchConceptsSpontaneous preterm birthPrevious spontaneous preterm birthRecurrent spontaneous preterm birthDelivery gestational ageRecurrent preterm birthPreterm birthSimilar gestational ageGestational ageHydroxyprogesterone caproateSingleton spontaneous preterm birthEarly spontaneous preterm birthFirst-degree family historyPreterm birth preventionHigh-risk womenPlanned secondary analysisPredictors of responseChi-square testPenultimate pregnancyPregnancy characteristicsNeonatal morbidityPregnancy coursePreterm pregnanciesBirth preventionCurrent pregnancyRegression modelsA Genome‐Wide Association Study of Early Spontaneous Preterm Delivery
Zhang H, Baldwin DA, Bukowski RK, Parry S, Xu Y, Song C, Andrews WW, Saade GR, Esplin MS, Sadovsky Y, Reddy UM, Ilekis J, Varner M, Biggio JR, Research F. A Genome‐Wide Association Study of Early Spontaneous Preterm Delivery. Genetic Epidemiology 2015, 39: 217-226. PMID: 25599974, PMCID: PMC4366311, DOI: 10.1002/gepi.21887.Peer-Reviewed Original ResearchConceptsSpontaneous preterm birthMaternal single nucleotide polymorphismsSPTB casesPreterm birthValidation cohortSingle nucleotide polymorphismsEarly spontaneous preterm deliveryP-valueTerm controlsTerm delivery controlsSpontaneous preterm deliveryMother-infant pairsCase-control studyIndependent validation cohortRace/ethnicityPreterm deliveryInfant morbidityMaternal ageControl groupMultiple testing adjustmentMultiple comparisonsCohortBirthNucleotide polymorphismsGenome-wide association studies
2014
Maternal serum serpin B7 is associated with early spontaneous preterm birth
Parry S, Zhang H, Biggio J, Bukowski R, Varner M, Xu Y, Andrews WW, Saade GR, Esplin MS, Leite R, Ilekis J, Reddy UM, Sadovsky Y, Blair IA, Research E. Maternal serum serpin B7 is associated with early spontaneous preterm birth. American Journal Of Obstetrics And Gynecology 2014, 211: 678.e1-678.e12. PMID: 24954659, PMCID: PMC4254341, DOI: 10.1016/j.ajog.2014.06.035.Peer-Reviewed Original ResearchConceptsSpontaneous preterm birthEarly spontaneous preterm birthPreterm birthMaternal serumSerum samplesPrevious spontaneous preterm birthSubsequent preterm deliveryProtein expressionLower gestational ageGestational age windowsCase-control studyCandidate protein expressionSerum proteomic analysisIndividual serum samplesPooled serum samplesSpontaneous pretermPreterm deliveryWeeks' gestationGestational ageTerm deliveryPregnant womenSerum biomarkersSerum concentrationsFetal membranesClinical sitesFetal Growth and Risk of Stillbirth: A Population-Based Case–Control Study
Bukowski R, Hansen NI, Willinger M, Reddy UM, Parker CB, Pinar H, Silver RM, Dudley DJ, Stoll BJ, Saade GR, Koch MA, Rowland Hogue CJ, Varner MW, Conway DL, Coustan D, Goldenberg RL, . Fetal Growth and Risk of Stillbirth: A Population-Based Case–Control Study. PLOS Medicine 2014, 11: e1001633. PMID: 24755550, PMCID: PMC3995658, DOI: 10.1371/journal.pmed.1001633.Peer-Reviewed Original ResearchConceptsRisk of stillbirthCase-control studyFetal growthGestational ageLive birthsSevere SGAPopulation-based case-control studyStillbirth prevention strategiesExcessive fetal growthSingleton live birthsFetal growth abnormalitiesNormal fetal growthStillbirth risk factorsGestational age estimatesTiming of deathLGA pregnanciesSingleton stillbirthsIndividualized normsTerm pregnancyAssociation Between Stillbirth and Illicit Drug Use and Smoking During Pregnancy
Varner MW, Silver RM, Hogue C, Willinger M, Parker CB, Thorsten VR, Goldenberg RL, Saade GR, Dudley DJ, Coustan D, Stoll B, Bukowski R, Koch MA, Conway D, Pinar H, Reddy UM. Association Between Stillbirth and Illicit Drug Use and Smoking During Pregnancy. Obstetrics And Gynecology 2014, 123: 113-125. PMID: 24463671, PMCID: PMC3931517, DOI: 10.1097/aog.0000000000000052.Peer-Reviewed Original ResearchConceptsIllicit drug useCotinine assaysDrug useMaternal serum cotinine levelStillbirth Collaborative Research NetworkCannabis useSelf-reported smoking historyRisk of stillbirthLive-birth deliveriesSerum cotinine levelsCase-control studySecond-hand smokeUmbilical cord samplesIllicit drugsDose-response relationshipStillbirth deliverySmoking historyCotinine levelsMaternal serumSerum cotinineBirth deliveryCord homogenateSmoking useCord samplesStillbirth
2013
Bile acids in a multicenter, population-based case-control study of stillbirth
Silver RM, Parker CB, Goldenberg R, Reddy UM, Dudley DJ, Saade GR, Hogue CJ, Coustan D, Varner MW, Koch MA, Conway D, Bukowski R, Pinar H, Stoll B, Moore J, Willinger M. Bile acids in a multicenter, population-based case-control study of stillbirth. American Journal Of Obstetrics And Gynecology 2013, 210: 460.e1-460.e9. PMID: 24215860, PMCID: PMC4413928, DOI: 10.1016/j.ajog.2013.11.017.Peer-Reviewed Original ResearchConceptsPopulation-based case-control studyBile acid levelsCase-control studyLive birthsBile acidsStillbirth Collaborative Research NetworkAcid levelsBaseline risk factorsTerm live birthsPopulation-based studyCases of stillbirthTime of enrollmentProportion of womenMaternal serumClinical evidenceIntrahepatic cholestasisRisk factorsFetal anomaliesStillbirthElevated levelsWomenBirthSimilar proportionsCollaborative research networksResearch NetworkAntiphospholipid Antibodies in Stillbirth
Silver RM, Parker CB, Reddy UM, Goldenberg R, Coustan D, Dudley DJ, Saade GR, Stoll B, Koch MA, Conway D, Bukowski R, Hogue CJ, Pinar H, Moore J, Willinger M, Branch DW. Antiphospholipid Antibodies in Stillbirth. Obstetrics And Gynecology 2013, 122: 641-657. PMID: 23921873, PMCID: PMC5684877, DOI: 10.1097/aog.0b013e3182a1060e.Peer-Reviewed Original ResearchConceptsI antibodiesPopulation-based case-control studyLive-birth deliveriesOdds of stillbirthCase-control studyIgM anticardiolipinStillbirth deliveryAntiphospholipid antibodiesMaternal serumBirth deliveryLive birthsStillbirthElevated levelsAntibodiesIgGDeliveryAnticardiolipinMulticenterImmunoglobulinSerum
2011
Stillbirth Collaborative Research Network: design, methods and recruitment experience
Parker CB, Hogue CJ, Koch MA, Willinger M, Reddy UM, Thorsten VR, Dudley DJ, Silver RM, Coustan D, Saade GR, Conway D, Varner MW, Stoll B, Pinar H, Bukowski R, Carpenter M, Goldenberg R, Network F. Stillbirth Collaborative Research Network: design, methods and recruitment experience. Paediatric And Perinatal Epidemiology 2011, 25: 425-435. PMID: 21819424, PMCID: PMC3665402, DOI: 10.1111/j.1365-3016.2011.01218.x.Peer-Reviewed Original ResearchConceptsStillbirth Collaborative Research NetworkPost-mortem examinationMaternal interviewsPlacental pathological examinationMedical record abstractionCase-control studyCase-control study participantsTime of deliveryHigher consent ratesGeographical catchment areasRecruitment experienceRecruitment hospitalChart abstractionProspective enrollmentPlacental pathologyRecord abstractionWeeks' gestationPathological examinationRisk factorsConsent ratesLivebirthsStillbirthClinical sitesStudy participantsAdditional surveillance