2023
Cannabis Exposure and Adverse Pregnancy Outcomes Related to Placental Function
Metz T, Allshouse A, McMillin G, Greene T, Chung J, Grobman W, Haas D, Mercer B, Parry S, Reddy U, Saade G, Simhan H, Silver R. Cannabis Exposure and Adverse Pregnancy Outcomes Related to Placental Function. JAMA 2023, 330: 2191-2199. PMID: 38085313, PMCID: PMC10716715, DOI: 10.1001/jama.2023.21146.Peer-Reviewed Original ResearchConceptsPrimary composite outcomeAdverse pregnancy outcomesComposite outcomeFirst trimesterCannabis exposurePregnancy outcomesCannabis usePlacental functionPropensity score-weighted analysisNulliparous Pregnancy Outcomes StudyOngoing exposureMaternal cannabis useUrine cotinine assayUrine samplesMedical record abstractionPregnancy outcome dataGestational-age birthsBody mass indexGestational age windowsPregnancy Outcomes StudyUS medical centersOngoing cannabis useAdjudication of outcomesMaternal cannabisHypertensive disordersAssessing Intrauterine Retention according to Microscopic Stillbirth Features: A Cluster Analysis Approach
Cersonsky T, Saade G, Silver R, Reddy U, Dudley D, Pinar H. Assessing Intrauterine Retention according to Microscopic Stillbirth Features: A Cluster Analysis Approach. Fetal And Pediatric Pathology 2023, 42: 860-869. PMID: 37571967, PMCID: PMC10843727, DOI: 10.1080/15513815.2023.2246571.Peer-Reviewed Original ResearchMacroscopic lesions of maternal and fetal vascular malperfusion in stillborn placentas: Diagnosis in the absence of microscopic histopathological examination
Cersonsky T, Silver R, Saade G, Dudley D, Reddy U, Pinar H. Macroscopic lesions of maternal and fetal vascular malperfusion in stillborn placentas: Diagnosis in the absence of microscopic histopathological examination. Placenta 2023, 140: 60-65. PMID: 37536149, PMCID: PMC10530266, DOI: 10.1016/j.placenta.2023.07.296.Peer-Reviewed Original ResearchConceptsFetal vascular malperfusionMaternal vascular malperfusionVascular malperfusionLive birthsFVM lesionsGestational ageMacroscopic findingsAmsterdam Placental Workshop Group Consensus StatementStillbirth Collaborative Research NetworkMicroscopic histopathological examinationMicroscopic pathologic evaluationHistory of hypertensionOdds of stillbirthGroup Consensus StatementMultivariate logistic regressionMVM lesionsPathologic evaluationHistopathological examinationMaternal raceOdds ratioConsensus statementHigher oddsUmbilical cordStillbirthMaternal factorsCopy number variants and fetal structural abnormalities in stillborn fetuses: A secondary analysis of the Stillbirth Collaborative Research Network study
Workalemahu T, Dalton S, Son S, Allshouse A, Carey A, Page J, Blue N, Thorsten V, Goldenberg R, Pinar H, Reddy U, Silver R. Copy number variants and fetal structural abnormalities in stillborn fetuses: A secondary analysis of the Stillbirth Collaborative Research Network study. BJOG An International Journal Of Obstetrics & Gynaecology 2023, 131: 157-162. PMID: 37264725, PMCID: PMC10689565, DOI: 10.1111/1471-0528.17561.Peer-Reviewed Original ResearchConceptsCopy number variantsFetal structural malformationsAbnormal copy number variantsNumber variantsSingle nucleotide polymorphism arrayResearch Network StudyStillbirth casesDNA copy number variantsSpecific copy number variantsCardiac defectsPolymorphism arrayStructural malformationsSecondary analysisCraniofacial defectsGenesSpecific malformation typesFetal structural abnormalitiesWald chi-square testUnknown clinical significanceChi-square testKbSkeletal defectsBenign copy number variantsPathogenic deletionsClinical significancePlacental lesions associated with stillbirth by gestational age, according to feature importance: Results from the stillbirth collaborative research network
Cersonsky T, Cersonsky R, Saade G, Silver R, Reddy U, Goldenberg R, Dudley D, Pinar H. Placental lesions associated with stillbirth by gestational age, according to feature importance: Results from the stillbirth collaborative research network. Placenta 2023, 137: 59-64. PMID: 37080046, PMCID: PMC10192128, DOI: 10.1016/j.placenta.2023.04.005.Peer-Reviewed Original ResearchConceptsStillbirth Collaborative Research NetworkGestational agePlacental lesionsDifferent gestational agesCollaborative research networksResearch NetworkTerm stillbirthFetal mortalityPlacental featuresHistologic changesStillbirthLesionsWeeksStandard protocolPlacentaFurther investigationAgePrincipal covariatesPrevious studiesGestationMortality
2022
Copy number variants and fetal growth in stillbirths
Dalton S, Workalemahu T, Allshouse A, Page J, Reddy U, Saade G, Pinar H, Goldenberg R, Dudley D, Silver R. Copy number variants and fetal growth in stillbirths. American Journal Of Obstetrics And Gynecology 2022, 228: 579.e1-579.e11. PMID: 36356697, PMCID: PMC10149588, DOI: 10.1016/j.ajog.2022.11.1274.Peer-Reviewed Original ResearchConceptsAbnormal copy number variantsFetal growth abnormalitiesGestational ageOdds ratioStillbirth Collaborative Research NetworkGenetic abnormalitiesChromosomal microarrayGestational age outcomesGestational age infantsGrowth abnormalitiesClinical risk factorsCohort study designAdjusted odds ratioCopy number variantsUnknown clinical significancePathogenic copy number variantsPlacental insufficiencyAge infantsNumber variantsFetal growthMaternal ageRisk factorsClinical significanceHigh incidenceStillbirth
2021
Maternal serum fructosamine levels and stillbirth: a case–control study of the Stillbirth Collaborative Research Network
Arslan E, Allshouse A, Page J, Varner M, Thorsten V, Parker C, Dudley D, Saade G, Goldenberg R, Stoll B, Hogue C, Bukowski R, Conway D, Pinar H, Reddy U, Silver R. Maternal serum fructosamine levels and stillbirth: a case–control study of the Stillbirth Collaborative Research Network. BJOG An International Journal Of Obstetrics & Gynaecology 2021, 129: 619-626. PMID: 34529344, DOI: 10.1111/1471-0528.16922.Peer-Reviewed Original ResearchConceptsSerum fructosamine levelsFructosamine levelsCase-control studyTime of deliveryLive birthsStillbirth Collaborative Research NetworkLive birth controlsCases of stillbirthPotential confounding factorsGeographic catchment areaSingleton stillbirthsGlycaemic controlDiabetes statusMulticentre studyRoutine screeningFructosamine measurementsDiabetesStillbirthConfounding factorsSecondary analysisWomenBirthCollaborative research networksBirth controlResearch Network
2020
Stillbirth and fetal anomalies: secondary analysis of a case–control study
Son S, Allshouse A, Page J, Debbink M, Pinar H, Reddy U, Gibbins K, Stoll B, Parker C, Dudley D, Varner M, Silver R. Stillbirth and fetal anomalies: secondary analysis of a case–control study. BJOG An International Journal Of Obstetrics & Gynaecology 2020, 128: 252-258. PMID: 32946651, PMCID: PMC7902300, DOI: 10.1111/1471-0528.16517.Peer-Reviewed Original Research
2019
The impact of induction of labor at 39 weeks in low-risk women on the incidence of stillbirth
Po' G, Oliver EA, Reddy UM, Silver RM, Berghella V. The impact of induction of labor at 39 weeks in low-risk women on the incidence of stillbirth. American Journal Of Obstetrics And Gynecology 2019, 222: 88-90. PMID: 31545942, DOI: 10.1016/j.ajog.2019.09.032.Peer-Reviewed Original Research
2018
Stillbirth, Inflammatory Markers, and Obesity: Results from the Stillbirth Collaborative Research Network
Harrison MS, Thorsten VR, Dudley DJ, Parker CB, Koch MA, Hogue CJR, Stoll BJ, Silver RM, Varner MW, Pinar MH, Coustan DR, Saade GR, Bukowski RK, Conway DL, Willinger M, Reddy UM, Goldenberg RL. Stillbirth, Inflammatory Markers, and Obesity: Results from the Stillbirth Collaborative Research Network. American Journal Of Perinatology 2018, 35: 1071-1078. PMID: 29609190, PMCID: PMC6436964, DOI: 10.1055/s-0038-1639340.Peer-Reviewed Original ResearchConceptsWhite blood cell countElevated white blood cell countBody mass indexBlood cell countSerum ferritin levelsC-reactive protein levelsNormal body mass indexMaternal serum ferritinInflammatory markersNormal-weight womenHistologic chorioamnionitisC-reactive proteinSerum ferritinLive birthsFerritin levelsCell countLogistic regression modelsWeight womenBMI categoriesCategories of BMIMaternal serum ferritin levelsStillbirth Collaborative Research NetworkPrepregnancy body mass indexElevated body mass indexLogistic regressionSmith–Lemli–Opitz Mutations in Unexplained Stillbirths
Gibbins KJ, Reddy UM, Saade GR, Goldenberg RL, Dudley DJ, Parker CB, Thorsten V, Pinar H, Bukowski R, Hogue CJ, Silver RM. Smith–Lemli–Opitz Mutations in Unexplained Stillbirths. American Journal Of Perinatology 2018, 35: 936-939. PMID: 29433144, PMCID: PMC6060008, DOI: 10.1055/s-0038-1626705.Peer-Reviewed Original ResearchConceptsUnexplained stillbirthLive birthsPopulation-based case-control studyCase-control studySmith-LemliAutosomal recessive syndromeObstetric complicationsHistologic featuresExon 3Placental tissueStillbirthRecessive syndromeDeoxyribonucleic acidStrong associationBidirectional sequencingDHCR7 mutationsCompound heterozygotesSyndromeCholesterol biosynthesisOpitz syndromeHomozygote frequencyBirthRepresentative sampleSLOS mutationsDHCR7Potentially Preventable Stillbirth in a Diverse U.S. Cohort
Page JM, Thorsten V, Reddy UM, Dudley DJ, Hogue CJR, Saade GR, Pinar H, Parker CB, Conway D, Stoll BJ, Coustan D, Bukowski R, Varner MW, Goldenberg RL, Gibbins K, Silver RM. Potentially Preventable Stillbirth in a Diverse U.S. Cohort. Obstetrics And Gynecology 2018, 131: 336-343. PMID: 29324601, PMCID: PMC5785410, DOI: 10.1097/aog.0000000000002421.Peer-Reviewed Original ResearchConceptsStillbirth Collaborative Research NetworkPreventable stillbirthsPlacental insufficiencyHypertensive disordersMultiple gestationsMedical complicationsPopulation-based case-control studyDiverse U.S. cohortSpontaneous preterm birthMedical record abstractionWeeks of gestationCases of stillbirthCase-control studyCollaborative research networksResearch NetworkStillbirth reductionPreterm laborPreterm birthPlacental pathologyRecord abstractionNonanomalous fetusesMaternal interviewsPostmortem examinationU.S. cohortStillbirth
2017
Altered fetal growth, placental abnormalities, and stillbirth
Bukowski R, Hansen NI, Pinar H, Willinger M, Reddy UM, Parker CB, Silver RM, Dudley DJ, Stoll BJ, Saade GR, Koch MA, Hogue C, Varner MW, Conway DL, Coustan D, Goldenberg RL, . Altered fetal growth, placental abnormalities, and stillbirth. PLOS ONE 2017, 12: e0182874. PMID: 28820889, PMCID: PMC5562325, DOI: 10.1371/journal.pone.0182874.Peer-Reviewed Original ResearchConceptsFetal growth abnormalitiesAltered fetal growthFetal growthLive birthsPlacental abnormalitiesPlacental findingsGrowth abnormalitiesImpaired placental functionSingleton live birthsCase-control studyCause of deathPatterns of associationSingleton stillbirthsPlacental examinationTerm stillbirthGestational ageRisk factorsPerinatal pathologistsPlacental functionClinical careStillbirthAbnormalitiesStandardized protocolBirthDeathDiagnostic Tests for Evaluation of Stillbirth
Page JM, Christiansen-Lindquist L, Thorsten V, Parker CB, Reddy UM, Dudley DJ, Saade GR, Coustan D, Hogue C, Conway D, Bukowski R, Pinar H, Heuser CC, Gibbins KJ, Goldenberg RL, Silver RM. Diagnostic Tests for Evaluation of Stillbirth. Obstetrics And Gynecology 2017, 129: 699-706. PMID: 28333795, DOI: 10.1097/aog.0000000000001937.Peer-Reviewed Original ResearchConceptsStillbirth Collaborative Research NetworkCause of deathAntiphospholipid antibodiesPlacental pathologyDiagnostic testsEvaluation of stillbirthMedical record abstractionPopulation-based studyCollaborative research networksDeath classification systemResearch NetworkRecord abstractionSyphilis serologyClinical presentationToxicology screenAntibody screenClinical historyMaternal interviewsStillbirthSecondary analysisGenetic testingUseful testBiospecimen collectionStandardized evaluationMost participantsRoute of Delivery in Women With Stillbirth
Boyle A, Preslar JP, Hogue CJ, Silver RM, Reddy UM, Goldenberg RL, Stoll BJ, Varner MW, Conway DL, Saade GR, Bukowski R, Dudley DJ. Route of Delivery in Women With Stillbirth. Obstetrics And Gynecology 2017, 129: 693-698. PMID: 28333794, PMCID: PMC5370197, DOI: 10.1097/aog.0000000000001935.Peer-Reviewed Original ResearchConceptsPrior cesarean deliveryCesarean deliveryObstetric indicationsSingleton stillbirthsUterine ruptureMulticenter case seriesRepeat cesarean deliveryRetrospective chart reviewInduction of laborWeeks of gestationRoute of deliveryMode of deliveryLabor inductionSecondary outcomesChart reviewIntrapartum stillbirthPrimary outcomeSpontaneous laborVaginal deliveryCase seriesMedical recordsTotal casesStillbirthWomenDelivery information
2016
Stillbirth, hypertensive disorders of pregnancy, and placental pathology
Gibbins KJ, Silver RM, Pinar H, Reddy UM, Parker CB, Thorsten V, Willinger M, Dudley DJ, Bukowski R, Saade GR, Koch MA, Conway D, Hogue CJ, Stoll BJ, Goldenberg RL. Stillbirth, hypertensive disorders of pregnancy, and placental pathology. Placenta 2016, 43: 61-68. PMID: 27324101, PMCID: PMC5893308, DOI: 10.1016/j.placenta.2016.04.020.Peer-Reviewed Original ResearchConceptsPlacental pathologyParenchymal infarctionLive birthsPreterm stillbirthSimilar clinical risk factorsStillbirth Collaborative Research NetworkPopulation-based cohort studyFetal vascular lesionsClinical risk factorsFeto-placental ratioGestational hypertensionRetroplacental hematomaHypertensive disordersCohort studyPlacental lesionsVascular lesionsAvascular villiFibrin depositionRisk factorsVascular thrombiStillbirthPregnancySecondary analysisInfarctionGHFactor V Leiden, prothrombin G20210A, and methylene tetrahydrofolate reductase mutations and stillbirth: the Stillbirth Collaborative Research Network
Silver RM, Saade GR, Thorsten V, Parker CB, Reddy UM, Drews-Botsch C, Conway D, Coustan D, Dudley DJ, Bukowski R, Hogue C, Pinar H, Varner MW, Goldenberg R, Willinger M. Factor V Leiden, prothrombin G20210A, and methylene tetrahydrofolate reductase mutations and stillbirth: the Stillbirth Collaborative Research Network. American Journal Of Obstetrics And Gynecology 2016, 215: 468.e1-468.e17. PMID: 27131585, DOI: 10.1016/j.ajog.2016.04.026.Peer-Reviewed Original ResearchConceptsFactor V LeidenStillbirth Collaborative Research NetworkCase-control studyHeritable thrombophiliaV LeidenProthrombin G20210AFetal thrombophiliaOdds ratioPAI-1 4G/4G polymorphismPopulation-based case-control studyMaternal factor V LeidenHomozygous factor V Leiden mutationFactor V Leiden mutationEvaluation of stillbirthTetrahydrofolate reductase mutationOdds of stillbirthV Leiden mutationTetrahydrofolate reductase C677TCollaborative research networksReductase C677TResearch NetworkMaternal thrombophiliaThrombophilia markersSingleton pregnanciesIncreased oddsStillbirths: recall to action in high-income countries
Flenady V, Wojcieszek A, Middleton P, Ellwood D, Erwich J, Coory M, Khong T, Silver R, Smith G, Boyle F, Lawn J, Blencowe H, Leisher S, Gross M, Horey D, Farrales L, Bloomfield F, McCowan L, Brown S, Joseph K, Zeitlin J, Reinebrant H, Cacciatore J, Ravaldi C, Vannacci A, Cassidy J, Cassidy P, Farquhar C, Wallace E, Siassakos D, Heazell A, Storey C, Sadler L, Petersen S, Frøen J, Goldenberg R, Flenady V, Frøen J, Kinney M, de Bernis L, Lawn J, Blencowe H, Heazell A, Leisher S, Ruidiaz J, Carvalho A, Dahlstrom J, East C, Fox J, Gibbons K, Ibiebele I, Kildea S, Gardener G, Lourie R, Wilson P, Gordon A, Jennings B, Kent A, McDonald S, Merchant K, Oats J, Walker S, Raven L, Schirmann A, de Montigny F, Guyon G, Blondel B, de Wall S, Bonham S, Corcoran P, Cregan M, Meany S, Murphy M, Fukui S, Gordijn S, Korteweg F, Cronin R, Mason V, Culling V, Usynina A, Pettersson K, Rådestad I, van Gogh S, Bichara B, Bradley S, Ellis A, Downe S, Draper E, Manktelow B, Scott J, Smith L, Stones W, Lavender T, Duke W, Fretts R, Gold K, McClure E, Reddy U. Stillbirths: recall to action in high-income countries. The Lancet 2016, 387: 691-702. PMID: 26794070, DOI: 10.1016/s0140-6736(15)01020-x.Peer-Reviewed Original ResearchMeSH KeywordsAttitude to HealthData AccuracyDelivery of Health CareDeveloped CountriesFemaleGestational AgeGlobal HealthHealth PolicyHealthcare DisparitiesHospice CareHumansIncomeInternational CooperationPerinatal MortalityPostnatal CarePractice Guidelines as TopicPregnancyPrenatal CareRisk FactorsStereotypingStillbirthConceptsHigh-income countriesStillbirth rateLate gestation stillbirthAdverse socioeconomic circumstancesIntrapartum stillbirthUnexplained stillbirthBereavement careStillbirthCare contributesStillborn childSocioeconomic circumstancesCausal pathwaysAdvantaged counterpartsDisadvantaged familiesEquity gapCareWomen
2014
Fetal Growth and Risk of Stillbirth: A Population-Based Case–Control Study
Bukowski R, Hansen NI, Willinger M, Reddy UM, Parker CB, Pinar H, Silver RM, Dudley DJ, Stoll BJ, Saade GR, Koch MA, Rowland Hogue CJ, Varner MW, Conway DL, Coustan D, Goldenberg RL, . Fetal Growth and Risk of Stillbirth: A Population-Based Case–Control Study. PLOS Medicine 2014, 11: e1001633. PMID: 24755550, PMCID: PMC3995658, DOI: 10.1371/journal.pmed.1001633.Peer-Reviewed Original ResearchConceptsRisk of stillbirthCase-control studyFetal growthGestational ageLive birthsSevere SGAPopulation-based case-control studyStillbirth prevention strategiesExcessive fetal growthSingleton live birthsFetal growth abnormalitiesNormal fetal growthStillbirth risk factorsGestational age estimatesTiming of deathLGA pregnanciesSingleton stillbirthsIndividualized normsTerm pregnancyAssociation Between Stillbirth and Illicit Drug Use and Smoking During Pregnancy
Varner MW, Silver RM, Hogue C, Willinger M, Parker CB, Thorsten VR, Goldenberg RL, Saade GR, Dudley DJ, Coustan D, Stoll B, Bukowski R, Koch MA, Conway D, Pinar H, Reddy UM. Association Between Stillbirth and Illicit Drug Use and Smoking During Pregnancy. Obstetrics And Gynecology 2014, 123: 113-125. PMID: 24463671, PMCID: PMC3931517, DOI: 10.1097/aog.0000000000000052.Peer-Reviewed Original ResearchConceptsIllicit drug useCotinine assaysDrug useMaternal serum cotinine levelStillbirth Collaborative Research NetworkCannabis useSelf-reported smoking historyRisk of stillbirthLive-birth deliveriesSerum cotinine levelsCase-control studySecond-hand smokeUmbilical cord samplesIllicit drugsDose-response relationshipStillbirth deliverySmoking historyCotinine levelsMaternal serumSerum cotinineBirth deliveryCord homogenateSmoking useCord samplesStillbirth