2024
Genetic polymorphisms associated with adverse pregnancy outcomes in nulliparas
Khan R, Guerrero R, Wapner R, Hahn M, Raja A, Salleb-Aouissi A, Grobman W, Simhan H, Silver R, Chung J, Reddy U, Radivojac P, Pe’er I, Haas D. Genetic polymorphisms associated with adverse pregnancy outcomes in nulliparas. Scientific Reports 2024, 14: 10514. PMID: 38714721, PMCID: PMC11076516, DOI: 10.1038/s41598-024-61218-9.Peer-Reviewed Original ResearchMeSH KeywordsAdultDiabetes, GestationalFemaleGenetic Predisposition to DiseaseGenome-Wide Association StudyHumansParityPolymorphism, Single NucleotidePre-EclampsiaPregnancyPregnancy OutcomeConceptsGenome-wide association studiesAdverse pregnancy outcomesMulti-ancestry genome-wide association studyCluster of SNPsGestational diabetesPregnancy outcomesAdmixed AmericansNovel lociPregnancy lossAssociation studiesGenetic markersIncreased risk of pregnancy lossTRMU geneGenetic ancestryAssociated with gestational diabetesRisk of pregnancy lossSub-cohortProportion of pregnanciesCause of morbidityLociAssociation TestSNPsPreterm birthMaternal riskIncreased risk
2023
Searching and visualizing genetic associations of pregnancy traits by using GnuMoM2b
Yan Q, Guerrero R, Khan R, Surujnarine A, Wapner R, Hahn M, Raja A, Salleb-Aouissi A, Grobman W, Simhan H, Blue N, Silver R, Chung J, Reddy U, Radivojac P, Pe’er I, Haas D. Searching and visualizing genetic associations of pregnancy traits by using GnuMoM2b. Genetics 2023, 225: iyad151. PMID: 37602697, PMCID: PMC10691790, DOI: 10.1093/genetics/iyad151.Peer-Reviewed Original ResearchMeSH KeywordsFemaleGenome-Wide Association StudyHumansPhenomicsPhenotypePolymorphism, Single NucleotidePregnancyRisk FactorsConceptsAdverse pregnancy outcomesNulliparous Pregnancy Outcomes StudyPregnancy Outcomes StudyMajor risk factorGenome-wide association studiesPregnancy outcomesGenetic associationMonitoring MothersRisk factorsOutcome studiesWomen's healthPhenome-wide association studySingle nucleotide polymorphismsAssociation studiesGenetic resultsPregnancyNucleotide polymorphisms
2015
Cluster analysis of spontaneous preterm birth phenotypes identifies potential associations among preterm birth mechanisms
Esplin MS, Manuck TA, Varner MW, Christensen B, Biggio J, Bukowski R, Parry S, Zhang H, Huang H, Andrews W, Saade G, Sadovsky Y, Reddy UM, Ilekis J. Cluster analysis of spontaneous preterm birth phenotypes identifies potential associations among preterm birth mechanisms. American Journal Of Obstetrics And Gynecology 2015, 213: 429.e1-429.e9. PMID: 26070700, PMCID: PMC4556543, DOI: 10.1016/j.ajog.2015.06.011.Peer-Reviewed Original ResearchMeSH KeywordsAdultCase-Control StudiesCluster AnalysisFemaleGenetic MarkersGenotypeHumansInsulinLogistic ModelsPhenotypePolymorphism, Single NucleotidePregnancyPremature BirthProspective StudiesRisk FactorsConceptsSpontaneous preterm birthDecidual hemorrhagePlacental dysfunctionProspective case-control multicenter studyCase-control multicenter studyPremature membrane ruptureGroup of womenCommon biologic pathwaysMaternal comorbiditiesPreterm singletonsPreterm birthWeeks' gestationMulticenter studyMaternal stressSecondary analysisBiologic pathwaysFamilial factorsGenetic factorsWomenPhenotypic profileGestationInfectionMembrane ruptureCommon mechanismPhenotypeThe association of beta‐2 adrenoceptor genotype with short‐cervix mediated preterm birth: a case–control study
Miller R, Smiley R, Thom E, Grobman W, Iams J, Mercer B, Saade G, Tita A, Reddy U, Rouse D, Sorokin Y, Blackwell S, Esplin, Tolosa J, Caritis, Network E. The association of beta‐2 adrenoceptor genotype with short‐cervix mediated preterm birth: a case–control study. BJOG An International Journal Of Obstetrics & Gynaecology 2015, 122: 1387-1394. PMID: 25600430, PMCID: PMC4508241, DOI: 10.1111/1471-0528.13243.Peer-Reviewed Original ResearchConceptsShort cervixCervical lengthAR genotypeMaternal-Fetal Medicine Units NetworkEunice Kennedy Shriver National InstituteNormal cervical lengthShort cervical lengthShort cervix groupPreterm birth riskCase-control studyRace/ethnicitySpontaneous PTBNulliparous womenPregnancy outcomesPreterm birthTransvaginal sonogramsPrimary outcomePTB riskSecond trimesterAncillary studiesChild healthBirth riskCervixAdrenoceptor genotypeControl groupA Genome‐Wide Association Study of Early Spontaneous Preterm Delivery
Zhang H, Baldwin DA, Bukowski RK, Parry S, Xu Y, Song C, Andrews WW, Saade GR, Esplin MS, Sadovsky Y, Reddy UM, Ilekis J, Varner M, Biggio JR, Research F. A Genome‐Wide Association Study of Early Spontaneous Preterm Delivery. Genetic Epidemiology 2015, 39: 217-226. PMID: 25599974, PMCID: PMC4366311, DOI: 10.1002/gepi.21887.Peer-Reviewed Original ResearchConceptsSpontaneous preterm birthMaternal single nucleotide polymorphismsSPTB casesPreterm birthValidation cohortSingle nucleotide polymorphismsEarly spontaneous preterm deliveryP-valueTerm controlsTerm delivery controlsSpontaneous preterm deliveryMother-infant pairsCase-control studyIndependent validation cohortRace/ethnicityPreterm deliveryInfant morbidityMaternal ageControl groupMultiple testing adjustmentMultiple comparisonsCohortBirthNucleotide polymorphismsGenome-wide association studies