2023
Cervical Pessary for Prevention of Preterm Birth in Individuals With a Short Cervix
Hoffman M, Clifton R, Biggio J, Saade G, Ugwu L, Longo M, Bousleiman S, Clark K, Grobman W, Frey H, Chauhan S, Dugoff L, Manuck T, Chien E, Rouse D, Simhan H, Esplin M, Macones G, Bickus M, Facco F, Tita A, Grant J, Casey B, Harris S, Harper L, Dunn D, Longo S, Hendricks M, Lata-Arias K, Costantine M, Bartholomew A, Cline D, Harper S, Ward C, Gardner N, Brindle S, Weigand S, McKenna D, Snow E, Fennig K, Habli M, Lambers D, McClellan M, Metz T, Sowles A, Varner M, Hill K, Morby V, Meadows C, Allard D, Werner E, Rousseau J, Milano J, Pettker C, Leventhal J, Gyamfi-Bannerman C, Wapner R, Carmona V, Firman B, Vanneman A, Palomares K, Beche I, Skupski D, Chan-Akeley R, Salazar A, Pacheco L, McCoy L, Saad A, Jain S, Omere C, Clifford C, McDonnold M, Chien E, Dalton W, Polito L, Milluzi C, Kushner K, Maile A, Bell J, Hackney D, Ortiz F, Timlin S, Goodnight W, Manuck T, Beamon C, Nun H, Eichelberger K, Moore A, Hughes B, Ferrara J, Grobman W, Mallett G, Stein L, Miller E, Plunkett B, Kearns K, Palatnik A, Malone T, Parry S, Pizzi C, Craig J, Filipczak A, Thom E, Doherty L, Hubbard A, Erikson P, Pinto T, Marcharchand P, Reddy U, Miodovnik M, Archer S. Cervical Pessary for Prevention of Preterm Birth in Individuals With a Short Cervix. JAMA 2023, 330: 340-348. PMID: 37490086, PMCID: PMC10369212, DOI: 10.1001/jama.2023.10812.Peer-Reviewed Original ResearchConceptsCervical pessaryUsual carePreterm birthShort cervixVaginal progesteroneCervical lengthSingleton pregnanciesFetal deathPrimary outcomeInfant deathPrior spontaneous preterm birthTransvaginal ultrasound cervical lengthCervical pessary placementWeeks 0 daysSpontaneous preterm birthUltrasound cervical lengthWeeks 6 daysThird interim analysisNeonatal/infant mortalityPreterm deliverySingleton gestationsBaseline characteristicsUltrasound evidencePessary placementTransvaginal ultrasoundPROMPT: Prospective Meta-analysis for Pessary Trials Study Protocol
Thom E, Saade G, Askie L, Ugwu L, Mol B, Vayssiere C, Norman J, Pajkrt E, Clifton R, Biggio J, Arnaud C, Berghella V, Canino M, Carreras E, Dugoff L, Hoffman M, Pacagnella R, Reddy U, Saccone G, van 't Hooft J, Dang V, Collaboration F. PROMPT: Prospective Meta-analysis for Pessary Trials Study Protocol. American Journal Of Perinatology 2023, 41: e2230-e2237. PMID: 37429323, PMCID: PMC10776795, DOI: 10.1055/s-0043-1771018.Peer-Reviewed Original ResearchShort cervical lengthPreterm birthIndividual patient dataShort cervixRandomized trialsPessary trialCervical lengthTwin gestationsSubsequent spontaneous preterm birthLong-term neurological disabilityOngoing randomized trialsSpontaneous preterm birthTrial study protocolWeeks of gestationProspective Meta-AnalysisSignificant health issueCervical supportNeonatal morbidityPreterm deliverySingleton gestationsSecondary outcomesFetal deathNeurological disabilityPrimary outcomeWeeks' gestation
2015
The association of beta‐2 adrenoceptor genotype with short‐cervix mediated preterm birth: a case–control study
Miller R, Smiley R, Thom E, Grobman W, Iams J, Mercer B, Saade G, Tita A, Reddy U, Rouse D, Sorokin Y, Blackwell S, Esplin, Tolosa J, Caritis, Network E. The association of beta‐2 adrenoceptor genotype with short‐cervix mediated preterm birth: a case–control study. BJOG An International Journal Of Obstetrics & Gynaecology 2015, 122: 1387-1394. PMID: 25600430, PMCID: PMC4508241, DOI: 10.1111/1471-0528.13243.Peer-Reviewed Original ResearchConceptsShort cervixCervical lengthAR genotypeMaternal-Fetal Medicine Units NetworkEunice Kennedy Shriver National InstituteNormal cervical lengthShort cervical lengthShort cervix groupPreterm birth riskCase-control studyRace/ethnicitySpontaneous PTBNulliparous womenPregnancy outcomesPreterm birthTransvaginal sonogramsPrimary outcomePTB riskSecond trimesterAncillary studiesChild healthBirth riskCervixAdrenoceptor genotypeControl group