2018
Potentially Preventable Stillbirth in a Diverse U.S. Cohort
Page JM, Thorsten V, Reddy UM, Dudley DJ, Hogue CJR, Saade GR, Pinar H, Parker CB, Conway D, Stoll BJ, Coustan D, Bukowski R, Varner MW, Goldenberg RL, Gibbins K, Silver RM. Potentially Preventable Stillbirth in a Diverse U.S. Cohort. Obstetrics And Gynecology 2018, 131: 336-343. PMID: 29324601, PMCID: PMC5785410, DOI: 10.1097/aog.0000000000002421.Peer-Reviewed Original ResearchConceptsStillbirth Collaborative Research NetworkPreventable stillbirthsPlacental insufficiencyHypertensive disordersMultiple gestationsMedical complicationsPopulation-based case-control studyDiverse U.S. cohortSpontaneous preterm birthMedical record abstractionWeeks of gestationCases of stillbirthCase-control studyCollaborative research networksResearch NetworkStillbirth reductionPreterm laborPreterm birthPlacental pathologyRecord abstractionNonanomalous fetusesMaternal interviewsPostmortem examinationU.S. cohortStillbirth
2013
Karyotype Versus Microarray Testing for Genetic Abnormalities After Stillbirth
Reddy U, Page G, Saade G, Silver R, Thorsten V, Parker C, Pinar H, Willinger M, Stoll B, Heim-Hall J, Varner M, Goldenberg R, Bukowski R, Wapner R, Drews-Botsch C, O’Brien B, Dudley D, Levy B. Karyotype Versus Microarray Testing for Genetic Abnormalities After Stillbirth. Obstetrical & Gynecological Survey 2013, 68: 278-280. DOI: 10.1097/01.ogx.0000429295.65513.69.Peer-Reviewed Original ResearchMicroarray analysisUnknown significancePathogenic variantsAntepartum stillbirthPostmortem examinationKaryotype analysisMore abnormalitiesPlacental tissueMicroarray resultsStillbirth Collaborative Research NetworkBenign variantsMicroarray testingPopulation-based studyGenomic abnormalitiesGeographic catchment areaStandard karyotype analysisCopy number variantsCord bloodClinical significanceNonviable tissueClinical relevanceStillbirthAbnormal karyotypeClinical implicationsFetal tissues
2012
Karyotype versus Microarray Testing for Genetic Abnormalities after Stillbirth
Reddy UM, Page GP, Saade GR, Silver RM, Thorsten VR, Parker CB, Pinar H, Willinger M, Stoll BJ, Heim-Hall J, Varner MW, Goldenberg RL, Bukowski R, Wapner RJ, Drews-Botsch CD, O'Brien BM, Dudley DJ, Levy B. Karyotype versus Microarray Testing for Genetic Abnormalities after Stillbirth. New England Journal Of Medicine 2012, 367: 2185-2193. PMID: 23215556, PMCID: PMC4295117, DOI: 10.1056/nejmoa1201569.Peer-Reviewed Original ResearchConceptsGenetic abnormalitiesAntepartum stillbirthCongenital anomaliesMicroarray analysisStillbirth Collaborative Research NetworkCopy number variantsAnalysis of stillbirthPopulation-based studyKaryotype analysisResults of karyotypeGeographic catchment areaSingle nucleotide polymorphism arrayClinical significancePostmortem examinationNonviable tissueStillbirthTrue prevalenceFetal tissuesUnaffected personsAbnormalitiesKaryotype resultsMicroarray testingCollaborative research networksGenetic diagnosisPolymorphism arrayCauses of Death Among Stillbirths
Bukowski R, Carpenter M, Conway D, Coustan D, Dudley D, Goldenberg R, Hogue C, Koch M, Parker C, Pinar H, Reddy U, Saade G, Silver R, Stoll B, Varner M, Willinger M. Causes of Death Among Stillbirths. Obstetrical & Gynecological Survey 2012, 67: 223-225. DOI: 10.1097/ogx.0b013e3182502211.Peer-Reviewed Original ResearchNon-Hispanic black womenCause of deathNon-Hispanic white womenPerinatal postmortem examinationPostmortem examinationStillbirth rateObstetric complicationsOutcome measuresMulticenter population-based case-control studyPopulation-based case-control studyWhite womenBlack womenMaternal medical complicationsCauses of stillbirthUmbilical cord abnormalitiesLive-birth deliveriesPopulation-based cohortCase-control studyComplete postmortem examinationMajority of casesHypertensive disordersPlacental histologyMedical complicationsTertiary careCord abnormalities
2011
The Stillbirth Collaborative Research Network Postmortem Examination Protocol
Pinar H, Koch M, Hawkins H, Heim-Hall J, Abramowsky C, Thorsten V, Carpenter M, Zhou H, Reddy U. The Stillbirth Collaborative Research Network Postmortem Examination Protocol. American Journal Of Perinatology 2011, 29: 187-202. PMID: 21815127, PMCID: PMC4320124, DOI: 10.1055/s-0031-1284228.Peer-Reviewed Original ResearchConceptsPostmortem examinationStillborn infantsEunice Kennedy Shriver National InstitutePerinatal postmortem examinationCauses of stillbirthTertiary care centerPopulation-based studyCare centerPerinatal pathologistsMedical CenterChild healthStillbirthExamination protocolNational InstituteStandardized approachInfantsResearch NetworkWomenTotalPM protocolPathogenesisCliniciansNICHDCenterNovel testing
2010
A New System for Determining the Causes of Stillbirth
Dudley DJ, Goldenberg R, Conway D, Silver RM, Saade GR, Varner MW, Pinar H, Coustan D, Bukowski R, Stoll B, Koch MA, Parker CB, Reddy UM. A New System for Determining the Causes of Stillbirth. Obstetrics And Gynecology 2010, 116: 254-260. PMID: 20664383, PMCID: PMC3832680, DOI: 10.1097/aog.0b013e3181e7d975.Peer-Reviewed Original ResearchConceptsCause of deathStillbirth Collaborative Research NetworkFetal deathInitial causePlacental pathologic findingsPlacental pathology dataCauses of stillbirthMaternal medical conditionsMedical record abstractionStrict diagnostic criteriaHistologic chorioamnionitisObstetric complicationsPlacental infectionFetal infectionPlacental pathologyRecord abstractionGestational agePathologic findingsPathophysiologic sequencePrenatal careClinical evaluationHematologic conditionsMaternal interviewsPostmortem examinationMedical conditions