2018
Smith–Lemli–Opitz Mutations in Unexplained Stillbirths
Gibbins KJ, Reddy UM, Saade GR, Goldenberg RL, Dudley DJ, Parker CB, Thorsten V, Pinar H, Bukowski R, Hogue CJ, Silver RM. Smith–Lemli–Opitz Mutations in Unexplained Stillbirths. American Journal Of Perinatology 2018, 35: 936-939. PMID: 29433144, PMCID: PMC6060008, DOI: 10.1055/s-0038-1626705.Peer-Reviewed Original ResearchConceptsUnexplained stillbirthLive birthsPopulation-based case-control studyCase-control studySmith-LemliAutosomal recessive syndromeObstetric complicationsHistologic featuresExon 3Placental tissueStillbirthRecessive syndromeDeoxyribonucleic acidStrong associationBidirectional sequencingDHCR7 mutationsCompound heterozygotesSyndromeCholesterol biosynthesisOpitz syndromeHomozygote frequencyBirthRepresentative sampleSLOS mutationsDHCR7Potentially Preventable Stillbirth in a Diverse U.S. Cohort
Page JM, Thorsten V, Reddy UM, Dudley DJ, Hogue CJR, Saade GR, Pinar H, Parker CB, Conway D, Stoll BJ, Coustan D, Bukowski R, Varner MW, Goldenberg RL, Gibbins K, Silver RM. Potentially Preventable Stillbirth in a Diverse U.S. Cohort. Obstetrics And Gynecology 2018, 131: 336-343. PMID: 29324601, PMCID: PMC5785410, DOI: 10.1097/aog.0000000000002421.Peer-Reviewed Original ResearchConceptsStillbirth Collaborative Research NetworkPreventable stillbirthsPlacental insufficiencyHypertensive disordersMultiple gestationsMedical complicationsPopulation-based case-control studyDiverse U.S. cohortSpontaneous preterm birthMedical record abstractionWeeks of gestationCases of stillbirthCase-control studyCollaborative research networksResearch NetworkStillbirth reductionPreterm laborPreterm birthPlacental pathologyRecord abstractionNonanomalous fetusesMaternal interviewsPostmortem examinationU.S. cohortStillbirth
2016
Factor V Leiden, prothrombin G20210A, and methylene tetrahydrofolate reductase mutations and stillbirth: the Stillbirth Collaborative Research Network
Silver RM, Saade GR, Thorsten V, Parker CB, Reddy UM, Drews-Botsch C, Conway D, Coustan D, Dudley DJ, Bukowski R, Hogue C, Pinar H, Varner MW, Goldenberg R, Willinger M. Factor V Leiden, prothrombin G20210A, and methylene tetrahydrofolate reductase mutations and stillbirth: the Stillbirth Collaborative Research Network. American Journal Of Obstetrics And Gynecology 2016, 215: 468.e1-468.e17. PMID: 27131585, DOI: 10.1016/j.ajog.2016.04.026.Peer-Reviewed Original ResearchConceptsFactor V LeidenStillbirth Collaborative Research NetworkCase-control studyHeritable thrombophiliaV LeidenProthrombin G20210AFetal thrombophiliaOdds ratioPAI-1 4G/4G polymorphismPopulation-based case-control studyMaternal factor V LeidenHomozygous factor V Leiden mutationFactor V Leiden mutationEvaluation of stillbirthTetrahydrofolate reductase mutationOdds of stillbirthV Leiden mutationTetrahydrofolate reductase C677TCollaborative research networksReductase C677TResearch NetworkMaternal thrombophiliaThrombophilia markersSingleton pregnanciesIncreased odds
2014
Fetal Growth and Risk of Stillbirth: A Population-Based Case–Control Study
Bukowski R, Hansen NI, Willinger M, Reddy UM, Parker CB, Pinar H, Silver RM, Dudley DJ, Stoll BJ, Saade GR, Koch MA, Rowland Hogue CJ, Varner MW, Conway DL, Coustan D, Goldenberg RL, . Fetal Growth and Risk of Stillbirth: A Population-Based Case–Control Study. PLOS Medicine 2014, 11: e1001633. PMID: 24755550, PMCID: PMC3995658, DOI: 10.1371/journal.pmed.1001633.Peer-Reviewed Original ResearchConceptsRisk of stillbirthCase-control studyFetal growthGestational ageLive birthsSevere SGAPopulation-based case-control studyStillbirth prevention strategiesExcessive fetal growthSingleton live birthsFetal growth abnormalitiesNormal fetal growthStillbirth risk factorsGestational age estimatesTiming of deathLGA pregnanciesSingleton stillbirthsIndividualized normsTerm pregnancy
2013
Bile acids in a multicenter, population-based case-control study of stillbirth
Silver RM, Parker CB, Goldenberg R, Reddy UM, Dudley DJ, Saade GR, Hogue CJ, Coustan D, Varner MW, Koch MA, Conway D, Bukowski R, Pinar H, Stoll B, Moore J, Willinger M. Bile acids in a multicenter, population-based case-control study of stillbirth. American Journal Of Obstetrics And Gynecology 2013, 210: 460.e1-460.e9. PMID: 24215860, PMCID: PMC4413928, DOI: 10.1016/j.ajog.2013.11.017.Peer-Reviewed Original ResearchConceptsPopulation-based case-control studyBile acid levelsCase-control studyLive birthsBile acidsStillbirth Collaborative Research NetworkAcid levelsBaseline risk factorsTerm live birthsPopulation-based studyCases of stillbirthTime of enrollmentProportion of womenMaternal serumClinical evidenceIntrahepatic cholestasisRisk factorsFetal anomaliesStillbirthElevated levelsWomenBirthSimilar proportionsCollaborative research networksResearch NetworkAntiphospholipid Antibodies in Stillbirth
Silver RM, Parker CB, Reddy UM, Goldenberg R, Coustan D, Dudley DJ, Saade GR, Stoll B, Koch MA, Conway D, Bukowski R, Hogue CJ, Pinar H, Moore J, Willinger M, Branch DW. Antiphospholipid Antibodies in Stillbirth. Obstetrics And Gynecology 2013, 122: 641-657. PMID: 23921873, PMCID: PMC5684877, DOI: 10.1097/aog.0b013e3182a1060e.Peer-Reviewed Original ResearchConceptsI antibodiesPopulation-based case-control studyLive-birth deliveriesOdds of stillbirthCase-control studyIgM anticardiolipinStillbirth deliveryAntiphospholipid antibodiesMaternal serumBirth deliveryLive birthsStillbirthElevated levelsAntibodiesIgGDeliveryAnticardiolipinMulticenterImmunoglobulinSerumAn Algorithm for the Estimation of Gestational Age at the Time of Fetal Death
Conway DL, Hansen NI, Dudley DJ, Parker CB, Reddy UM, Silver RM, Bukowski R, Pinar H, Stoll BJ, Varner MW, Saade GR, Hogue C, Willinger M, Coustan D, Koch MA, Goldenberg RL, Network E. An Algorithm for the Estimation of Gestational Age at the Time of Fetal Death. Paediatric And Perinatal Epidemiology 2013, 27: 145-157. PMID: 23374059, PMCID: PMC3564237, DOI: 10.1111/ppe.12037.Peer-Reviewed Original ResearchConceptsStillbirth Collaborative Research NetworkFetal foot lengthFetal deathGestational agePopulation-based case-control studyFoot lengthWeeks of diagnosisCase-control studyGeographical catchment areasSingleton stillbirthsStillbirth casesPost-mortem dataStillbirthClinical practiceMore weeksDeathWeeksCollaborative research networksDiagnosisResearch NetworkShort intervalsLivebirthsWomen
2012
Causes of Death Among Stillbirths
Bukowski R, Carpenter M, Conway D, Coustan D, Dudley D, Goldenberg R, Hogue C, Koch M, Parker C, Pinar H, Reddy U, Saade G, Silver R, Stoll B, Varner M, Willinger M. Causes of Death Among Stillbirths. Obstetrical & Gynecological Survey 2012, 67: 223-225. DOI: 10.1097/ogx.0b013e3182502211.Peer-Reviewed Original ResearchNon-Hispanic black womenCause of deathNon-Hispanic white womenPerinatal postmortem examinationPostmortem examinationStillbirth rateObstetric complicationsOutcome measuresMulticenter population-based case-control studyPopulation-based case-control studyWhite womenBlack womenMaternal medical complicationsCauses of stillbirthUmbilical cord abnormalitiesLive-birth deliveriesPopulation-based cohortCase-control studyComplete postmortem examinationMajority of casesHypertensive disordersPlacental histologyMedical complicationsTertiary careCord abnormalities