2024
Pregnancy Outcomes in Patients With Hepatitis C Virus Infection
Hughes B, Sandoval G, Saade G, Clifton R, Reddy U, Bartholomew A, Salazar A, Chien E, Tita A, Thorp J, Metz T, Wapner R, Sabharwal V, Simhan H, Swamy G, Heyborne K, Sibai B, Grobman W, El-Sayed Y, Casey B, Parry S, Macones G, Prasad M. Pregnancy Outcomes in Patients With Hepatitis C Virus Infection. Obstetrics And Gynecology 2024, 144: 501-506. PMID: 39173174, DOI: 10.1097/aog.0000000000005703.Peer-Reviewed Original ResearchSmall-for-gestational-ageHepatitis C virusHepatitis C virus infectionCase groupIncreased oddsPreterm birthNeonatal infectionGestational diabetesMaternal outcomesHCV infectionBirth weightSmall-for-gestational-age birth weightAdmission to neonatal intensive careControl groupIncreased odds of preterm birthPositive hepatitis C virusOdds of NICU admissionOutcomes associated with pregnancyMulticenter prospective cohort studyOdds of preterm birthMaternal HCV infectionMaternal medical comorbiditiesSGA birth weightAdverse maternal outcomesC virus infectionDesign, rationale and protocol for Glycemic Observation and Metabolic Outcomes in Mothers and Offspring (GO MOMs): an observational cohort study
Group T, Scholtens D, LeBlanc E, Vesco K, Amy D, Bays K, Massimino S, Robinson S, Schell K, Walters G, Hillier T, Oshiro C, Cordero S, Howick C, Kim L, Martinez Y, Pishchalenko O, Wastlova V, Zork N, Mourad M, Lonier J, Reddy U, Acevedo J, Castillo J, Gomez M, Peguero B, Facco F, Feghali M, Bocan H, Stramowski S, Powe C, Edlow A, Barth W, Nathan D, Azevedo R, Baez A, Iroajanma C, Larkin M, Maya J, Michalopoulos C, Neamonitaki N, Thangthaeng N, Yee L, Lowe W, Grobman W, Szmuilowicz E, Aguirre A, Guevara E, Mallett G, Matos S, Tyagi S, Spadola A, Catalano P, Azimirad A, Werner E, Rouse D, Malloy M, Parra F, Sherr J, Merriam A, Bitterman S, Considine E, Leventhal J, Perley L, Rink L, Steffen A, Thompson B, Zgorski M, Steffes M, Arends V, Killeen A, Siddique J, Bustamante P, Cheung Y, Freeze C, Grott T, Kuang A, Tull M, Linder B. Design, rationale and protocol for Glycemic Observation and Metabolic Outcomes in Mothers and Offspring (GO MOMs): an observational cohort study. BMJ Open 2024, 14: e084216. PMID: 38851233, PMCID: PMC11163666, DOI: 10.1136/bmjopen-2024-084216.Peer-Reviewed Original ResearchConceptsLarge-for-gestational-age birth weightMetabolic outcomesLarge-for-gestational-ageDiagnosis of gestational diabetesOral glucose tolerance testAdverse pregnancy outcomesVanderbilt University Institutional Review BoardCourse of pregnancyObservational cohort studyGlucose tolerance testNational Institute of DiabetesDigestive and Kidney DiseasesGDM treatmentWeeks gestationDetect such abnormalitiesPerinatal outcomesGDM screeningInstitutional review boardGestational diabetesFirst-trimesterPregnancy outcomesEarly pregnancyGlucose abnormalitiesBirth weightPregnant adultsGenetic polymorphisms associated with adverse pregnancy outcomes in nulliparas
Khan R, Guerrero R, Wapner R, Hahn M, Raja A, Salleb-Aouissi A, Grobman W, Simhan H, Silver R, Chung J, Reddy U, Radivojac P, Pe’er I, Haas D. Genetic polymorphisms associated with adverse pregnancy outcomes in nulliparas. Scientific Reports 2024, 14: 10514. PMID: 38714721, PMCID: PMC11076516, DOI: 10.1038/s41598-024-61218-9.Peer-Reviewed Original ResearchConceptsGenome-wide association studiesAdverse pregnancy outcomesMulti-ancestry genome-wide association studyCluster of SNPsGestational diabetesPregnancy outcomesAdmixed AmericansNovel lociPregnancy lossAssociation studiesGenetic markersIncreased risk of pregnancy lossTRMU geneGenetic ancestryAssociated with gestational diabetesRisk of pregnancy lossSub-cohortProportion of pregnanciesCause of morbidityLociAssociation TestSNPsPreterm birthMaternal riskIncreased risk441 Association of nocturnal heart rate and development of gestational diabetes and hypertensive disorders of pregnancy
Fisher S, Huang X, Khan S, Grimaldi D, Zee P, Greenland P, Facco F, Basner R, Chung J, Grobman W, McNeil R, Pien G, Reddy U, Redline S, Silver R, Yee L. 441 Association of nocturnal heart rate and development of gestational diabetes and hypertensive disorders of pregnancy. American Journal Of Obstetrics And Gynecology 2024, 230: s242-s243. DOI: 10.1016/j.ajog.2023.11.467.Peer-Reviewed Original Research
2023
Community-level social determinants of health and pregestational and gestational diabetes
Field C, Grobman W, Yee L, Johnson J, Wu J, McNeil B, Mercer B, Simhan H, Reddy U, Silver R, Parry S, Saade G, Chung J, Wapner R, Lynch C, Venkatesh K. Community-level social determinants of health and pregestational and gestational diabetes. American Journal Of Obstetrics & Gynecology MFM 2023, 6: 101249. PMID: 38070680, PMCID: PMC11184512, DOI: 10.1016/j.ajogmf.2023.101249.Peer-Reviewed Original ResearchCommunity-level social determinantsGestational diabetesPregestational diabetesAdverse social determinantsSocial determinantsSocioeconomic disadvantageNulliparous Pregnancy Outcomes StudyGestational diabetes diagnosisArea deprivation index scoreMedicaid insurance statusRisk of diabetesPregnancy Outcomes StudyWalkable neighborhoodsDeprivation index scoreArea Deprivation IndexLower household incomeFood desertsGreater socioeconomic disadvantageChronic hypertensionHighest tertileFirst trimesterHigher socioeconomic disadvantageInsurance statusMonitoring MothersMultinomial logistic regression
2022
Association of a Mediterranean Diet Pattern With Adverse Pregnancy Outcomes Among US Women
Makarem N, Chau K, Miller E, Gyamfi-Bannerman C, Tous I, Booker W, Catov J, Haas D, Grobman W, Levine L, McNeil R, Merz C, Reddy U, Wapner R, Wong M, Bello N. Association of a Mediterranean Diet Pattern With Adverse Pregnancy Outcomes Among US Women. JAMA Network Open 2022, 5: e2248165. PMID: 36547978, PMCID: PMC9857221, DOI: 10.1001/jamanetworkopen.2022.48165.Peer-Reviewed Original ResearchConceptsAdverse pregnancy outcomesMediterranean diet patternTime of conceptionPregnancy outcomesDiet patternLower oddsAMED scoresGestational diabetesCohort studyUS womenLower riskRisk of APOsPrepregnancy body mass indexCardiovascular disease risk factorsSemiquantitative food frequency questionnaireAlternate Mediterranean diet scoreNulliparous Pregnancy Outcomes StudyLowest AMED scoresGestational age infantsDisease risk factorsDose-response associationFood frequency questionnaireMediterranean diet scoreBody mass indexCause of morbidityAssociation of Social Determinants of Health and Clinical Factors with Postpartum Hospital Readmissions among Nulliparous Individuals
Kumar N, Grobman W, Haas D, Silver R, Reddy U, Simhan H, Wing D, Mercer B, Yee L. Association of Social Determinants of Health and Clinical Factors with Postpartum Hospital Readmissions among Nulliparous Individuals. American Journal Of Perinatology 2022, 40: 348-355. PMID: 36427510, DOI: 10.1055/s-0042-1758485.Peer-Reviewed Original ResearchConceptsPostpartum readmissionSocial determinantsHypertensive disordersHigher oddsMulticenter prospective cohort studyPostpartum hospital readmissionProspective cohort studyInitial hospital dischargeHemorrhage requiring transfusionSuch risk factorsAntecedent diagnosisHDP patientsNulliparous participantsGestational diabetesIntrapartum complicationsPerinatal morbidityCesarean deliveryCohort studyHospital dischargeClinical factorsHospital readmissionPrimary outcomeBivariable analysisModifiable factorsInsurance status
2019
Effect of Treatment of Mild Gestational Diabetes on Long-Term Maternal Outcomes
Casey B, Rice M, Landon M, Varner M, Reddy U, Wapner R, Rouse D, Biggio J, Thorp J, Chien E, Saade G, Peaceman A, Blackwell S, Van Dorsten J. Effect of Treatment of Mild Gestational Diabetes on Long-Term Maternal Outcomes. American Journal Of Perinatology 2019, 37: 475-482. PMID: 30866027, PMCID: PMC6744360, DOI: 10.1055/s-0039-1681058.Peer-Reviewed Original ResearchConceptsMild gestational diabetes mellitusGestational diabetes mellitusBody mass indexMetabolic syndromeIndex pregnancyTreatment of womenSubsequent diabetesLong-term maternal outcomesMaternal body mass indexOral glucose tolerance testMild gestational diabetesFrequency of diabetesHomeostasis model assessmentGlucose tolerance testRisk of diabetesTreatment of diabetesEffect of treatmentRace/ethnicityGestational diabetesLipid panelMaternal outcomesBlood pressureDiabetes mellitusMedical therapyNutritional counseling