2024
Selective utilization of glucose metabolism guides mammalian gastrulation
Cao D, Bergmann J, Zhong L, Hemalatha A, Dingare C, Jensen T, Cox A, Greco V, Steventon B, Sozen B. Selective utilization of glucose metabolism guides mammalian gastrulation. Nature 2024, 634: 919-928. PMID: 39415005, PMCID: PMC11499262, DOI: 10.1038/s41586-024-08044-1.Peer-Reviewed Original ResearchConceptsCellular metabolismMammalian gastrulationHexosamine biosynthetic pathwayTranscription factor networksCellular signaling pathwaysSignaling morphogensGlucose metabolismCellular programmeBiosynthetic pathwayFate acquisitionCell fateHousekeeping natureGenetic mechanismsMesoderm migrationFactor networksERK activationExpression patternsSignaling pathwayDevelopmental processesStem cell modelCell typesSpecialized functionsDevelopmental contextMammalian embryosMouse embryos
2021
Lung injury in axolotl salamanders induces an organ‐wide proliferation response
Jensen TB, Giunta P, Schultz NG, Griffiths JM, Duerr TJ, Kyeremateng Y, Wong H, Adesina A, Monaghan JR. Lung injury in axolotl salamanders induces an organ‐wide proliferation response. Developmental Dynamics 2021, 250: 866-879. PMID: 33587313, DOI: 10.1002/dvdy.315.Peer-Reviewed Original ResearchConceptsLung regenerationLung massX cranial nervesLung injurySupplemental administrationCranial nervesProliferative responseProliferation responseInjury responseLungInjuryMultiple cell typesMesenchymal cellsNeuregulinAmputationMost tissuesPneumocytesProliferationCell typesResponseAxolotl salamanderCellsNerve
2017
Transcriptional correlates of proximal-distal identify and regeneration timing in axolotl limbs
Voss S, Murrugarra D, Jensen TB, Monaghan JR. Transcriptional correlates of proximal-distal identify and regeneration timing in axolotl limbs. Comparative Biochemistry And Physiology Part C Toxicology & Pharmacology 2017, 208: 53-63. PMID: 29107037, PMCID: PMC5920805, DOI: 10.1016/j.cbpc.2017.10.010.Peer-Reviewed Original ResearchConceptsAxolotl limbsDynamic transcriptional regulationSimilar transcriptional patternsCell cycle transcriptsDifferentiated muscle cellsProximal-distal limb axisExtracellular matrix moleculesMemory genesTranscriptional regulationTranscript abundanceTranscriptional patternsExpression patternsLimb regenerationGene expressionBlastema cellsPositional memoryArm cellsCell adhesionGenesMatrix moleculesCell surfaceEpithelial proteinsPositional informationTissue remodelingTranscriptional correlates
2015
Exploring drug delivery for the DOT1L inhibitor pinometostat (EPZ-5676): Subcutaneous administration as an alternative to continuous IV infusion, in the pursuit of an epigenetic target
Waters NJ, Daigle SR, Rehlaender BN, Basavapathruni A, Campbell CT, Jensen TB, Truitt BF, Olhava EJ, Pollock RM, Stickland KA, Dovletoglou A. Exploring drug delivery for the DOT1L inhibitor pinometostat (EPZ-5676): Subcutaneous administration as an alternative to continuous IV infusion, in the pursuit of an epigenetic target. Journal Of Controlled Release 2015, 220: 758-765. PMID: 26385168, DOI: 10.1016/j.jconrel.2015.09.023.Peer-Reviewed Original ResearchMeSH KeywordsAdministration, OralAnimalsAntineoplastic AgentsBenzimidazolesBiological AvailabilityChemistry, PharmaceuticalDelayed-Action PreparationsDNA MethylationDogsDrug Administration ScheduleDrug CarriersEnzyme InhibitorsEpigenesis, GeneticGene Expression Regulation, LeukemicHistone-Lysine N-MethyltransferaseHumansInfusions, IntravenousInjections, SubcutaneousLeukemia, Biphenotypic, AcuteMaleMethyltransferasesMiceRats, Sprague-DawleyTumor BurdenXenograft Model Antitumor AssaysConceptsXenograft modelRefractory acute leukemia patientsFurther evaluationPhase 1 clinical trialSubcutaneous bolus administrationAcute leukemia patientsTumor growth inhibitionDOT1L inhibitor pinometostatExtended-release formulationRat xenograft modelMLL-r leukemiaThrice dailyPharmacodynamic markersSC administrationBolus administrationClinical trialsSubcutaneous administrationComplete bioavailabilityDOT1L activityLeukemia patientsOral administrationPatient conveniencePreclinical studiesSmall molecule inhibitorsImproved exposure