2016
SILAC based protein profiling data of MKK3 knockout mouse embryonic fibroblasts
Srivastava A, Shinn AS, Lam TT, Lee PJ, Mannam P. SILAC based protein profiling data of MKK3 knockout mouse embryonic fibroblasts. Data In Brief 2016, 7: 418-422. PMID: 26977448, PMCID: PMC4782019, DOI: 10.1016/j.dib.2016.02.034.Peer-Reviewed Original ResearchMouse embryonic fibroblastsYale Protein Expression DatabaseIngenuity Pathway AnalysisEmbryonic fibroblastsKnockout mouse embryonic fibroblastsProtein Expression DatabaseWT mouse embryonic fibroblastsQuantitative mass spectrometryWhole cell lysatesTotal proteomeIntegrated DiscoveryMAP kinasePathway analysisAltered pathwaysCell lysatesMass spectrometry dataSILACPhosphopeptide enrichmentProtein levelsExpression databaseProteinSpectrometry dataPathwayFibroblastsMass spectrometry
2015
MKK3 deletion improves mitochondrial quality
Srivastava A, McGinniss J, Wong Y, Shinn AS, Lam TT, Lee PJ, Mannam P. MKK3 deletion improves mitochondrial quality. Free Radical Biology And Medicine 2015, 87: 373-384. PMID: 26119780, DOI: 10.1016/j.freeradbiomed.2015.06.024.Peer-Reviewed Original ResearchConceptsLPS treatmentMitochondrial membrane potentialIntensive care unitInflammatory cytokine releaseMAP kinase kinase 3Potential therapeutic targetBetter mitochondrial functionMitochondrial functionMitochondrial qualityMouse embryonic fibroblastsCare unitExcessive inflammationCytokine releaseInhibition of mitophagyInflammatory diseasesCytokine secretionInflammatory responseTherapeutic targetLipopolysaccharide (LPS) stimulationSeptic injuryRole of mitophagyMajor causeOxidant productionSevere responseSepsis