2024
High ambient temperature in pregnancy and risk of childhood acute lymphoblastic leukaemia: an observational study
Rogne T, Wang R, Wang P, Deziel N, Metayer C, Wiemels J, Chen K, Warren J, Ma X. High ambient temperature in pregnancy and risk of childhood acute lymphoblastic leukaemia: an observational study. The Lancet Planetary Health 2024, 8: e506-e514. PMID: 38969477, PMCID: PMC11260908, DOI: 10.1016/s2542-5196(24)00121-9.Peer-Reviewed Original ResearchConceptsRisk of childhood acute lymphoblastic leukemiaChildhood acute lymphoblastic leukemiaAcute lymphoblastic leukemiaLymphoblastic leukemiaLatino childrenNon-Latino white childrenAssociated with risk of adverse pregnancy outcomesCalifornia Cancer RegistryRisk of acute lymphoblastic leukemiaCalifornia birth recordsRisk of adverse pregnancy outcomesPre-pregnancy periodAssociated with riskBayesian meta-regressionNational Institutes of HealthCancer RegistryCases of childhood acute lymphoblastic leukemiaNational Center for Advancing Translational SciencesAdverse pregnancy outcomesAcute lymphoblastic leukemia casesInstitutes of HealthInvestigation of mechanistic pathwaysBirth recordsGestational weeks 8Pre-pregnancyMediating Factors in the Association of Maternal Educational Level With Pregnancy Outcomes
Rogne T, Gill D, Liew Z, Shi X, Stensrud V, Nilsen T, Burgess S. Mediating Factors in the Association of Maternal Educational Level With Pregnancy Outcomes. JAMA Network Open 2024, 7: e2351166. PMID: 38206626, PMCID: PMC10784860, DOI: 10.1001/jamanetworkopen.2023.51166.Peer-Reviewed Original ResearchMeSH KeywordsBirth WeightCholesterolCohort StudiesDiabetes Mellitus, Type 2Educational StatusFemaleGenome-Wide Association StudyHumansHyperemesis GravidarumInfant, NewbornLipoproteins, HDLMediation AnalysisMendelian Randomization AnalysisPre-EclampsiaPregnancyPregnancy OutcomePregnancy, EctopicPremature BirthConceptsCardiometabolic risk factorsBody mass indexOffspring birth weightEducational attainmentMendelian randomizationHigh-density lipoprotein cholesterol levelsSystolic blood pressureInverse variance-weighted methodModifiable cardiometabolic risk factorsPregnancy outcomesCohort studyLipoprotein cholesterol levelsMR-Egger regressionMass indexUnivariable MR analysisEffects of educational attainmentAssociated with increased risk of adverse pregnancy outcomesPublic health interventionsMaternal education levelLower educational attainmentRisk factorsRisk of adverse pregnancy outcomesGenome-wide association studiesAssociated with increased riskBirth weight
2023
Dyslipidemia and Risk of Preeclampsia: A Multiancestry Mendelian Randomization Study
Hosier H, Lipkind H, Rasheed H, DeWan A, Rogne T. Dyslipidemia and Risk of Preeclampsia: A Multiancestry Mendelian Randomization Study. Hypertension 2023, 80: 1067-1076. PMID: 36883459, DOI: 10.1161/hypertensionaha.122.20426.Peer-Reviewed Original ResearchConceptsRisk of preeclampsiaProtective effectCholesteryl Ester Transfer Protein InhibitionLack of effectMendelian randomization studyMendelian randomization analysisMaternal morbidityElevated HDLLeading causeLipid levelsObservational studyPreeclampsiaLipid measurementsReduced riskAncestry groupsPharmacological targetsRandomization studyHDLLDLRandomization analysisSingle nucleotide polymorphismsNew targetsDyslipidemiaRiskProtein inhibitionSex‐Specific Reproductive Factors Augment Cardiovascular Disease Risk in Women: A Mendelian Randomization Study
Ardissino M, Slob E, Carter P, Rogne T, Girling J, Burgess S, Ng F. Sex‐Specific Reproductive Factors Augment Cardiovascular Disease Risk in Women: A Mendelian Randomization Study. Journal Of The American Heart Association 2023, 12: e027933. PMID: 36846989, PMCID: PMC10111460, DOI: 10.1161/jaha.122.027933.Peer-Reviewed Original ResearchConceptsCoronary artery diseaseBody mass indexHeart failureCardiovascular diseaseReproductive factorsArtery diseaseIschemic strokeMass indexAtrial fibrillationLive birthsFirst birthCardiovascular disease riskType 2 diabetesBackground Observational studiesMendelian randomizationMendelian randomization studyModifiable mediatorsBlood pressureResidual confoundingObservational studyPrimary analysisRandomization studyDisease riskStrokeClinical interventionsOutdoor artificial light at night, air pollution, and risk of childhood acute lymphoblastic leukemia in the California Linkage Study of Early-Onset Cancers
Zhong C, Wang R, Morimoto L, Longcore T, Franklin M, Rogne T, Metayer C, Wiemels J, Ma X. Outdoor artificial light at night, air pollution, and risk of childhood acute lymphoblastic leukemia in the California Linkage Study of Early-Onset Cancers. Scientific Reports 2023, 13: 583. PMID: 36631468, PMCID: PMC9834257, DOI: 10.1038/s41598-022-23682-z.Peer-Reviewed Original ResearchConceptsAcute lymphoblastic leukemiaRisk of childhoodEarly-onset cancersLymphoblastic leukemiaBirth recordsChildhood acute lymphoblastic leukemiaNon-Hispanic white childrenHispanic childrenCalifornia Cancer RegistryEtiology of childhoodOutdoor artificial lightOutdoor ALANHighest tertileCancer RegistryLinkage studiesRisk factorsBorderline associationElevated riskCancer diagnosisCancerEnvironmental exposuresWhite childrenCommon typeAir pollutionRisk
2022
Iron status and the risk of sepsis and severe COVID-19: a two-sample Mendelian randomization study
Mohus RM, Flatby H, Liyanarachi KV, DeWan AT, Solligård E, Damås JK, Åsvold BO, Gustad LT, Rogne T. Iron status and the risk of sepsis and severe COVID-19: a two-sample Mendelian randomization study. Scientific Reports 2022, 12: 16157. PMID: 36171422, PMCID: PMC9516524, DOI: 10.1038/s41598-022-20679-6.Peer-Reviewed Original ResearchConceptsRisk of sepsisTwo-sample Mendelian randomization studyIron statusMendelian randomization studySerum ironOdds ratioCOVID-19Randomization studyTotal iron binding capacitySevere COVID-19Risk of hospitalizationHigh iron statusIron binding capacitySex-stratified analysesTransferrin saturationSevere infectionsIron biomarkersObservational studyHigh riskSepsisStandard deviation increaseHospitalizationFurther studiesRiskStatusIncidence, recurring admissions and mortality of severe bacterial infections and sepsis over a 22-year period in the population-based HUNT study
Liyanarachi KV, Solligård E, Mohus RM, Åsvold BO, Rogne T, Damås JK. Incidence, recurring admissions and mortality of severe bacterial infections and sepsis over a 22-year period in the population-based HUNT study. PLOS ONE 2022, 17: e0271263. PMID: 35819970, PMCID: PMC9275692, DOI: 10.1371/journal.pone.0271263.Peer-Reviewed Original ResearchConceptsSevere bacterial infectionsPositive blood culturesBacterial infectionsBlood culturesPopulation-based HUNT StudyPositive blood culture rateTrøndelag Health StudyUrinary tract infectionPopulation-based cohortBlood culture rateCommon infectious diseasesInfectious disease burdenRegistry linkageTract infectionsLoss of healthMedian timeHUNT StudyDisease burdenIncidence rateCulture rateGeneral populationHealth StudyHospitalizationImportant causeTotal burdenExplaining sex differences in risk of bloodstream infections using mediation analysis in the population-based HUNT study in Norway
Mohus RM, Gustad LT, Furberg AS, Moen MK, Liyanarachi KV, Askim Å, Åsberg SE, DeWan AT, Rogne T, Simonsen GS, Nilsen TIL, Åsvold BO, Damås JK, Solligård E. Explaining sex differences in risk of bloodstream infections using mediation analysis in the population-based HUNT study in Norway. Scientific Reports 2022, 12: 8436. PMID: 35589812, PMCID: PMC9118181, DOI: 10.1038/s41598-022-12569-8.Peer-Reviewed Original ResearchConceptsIncident bloodstream infectionCardiovascular risk factorsBloodstream infectionsBSI mortalityRisk factorsHigh riskHealth behaviorsFirst-time bloodstream infectionRisk of BSIPotential modifiable risk factorsPopulation-based HUNT StudyModifiable risk factorsSex differencesHospital recordsProspective studyHUNT StudyExcess riskMediation analysisCausal mediation analysisEffects of sexMortalityComorbiditiesWomenMenRiskSmoking and infertility: multivariable regression and Mendelian randomization analyses in the Norwegian Mother, Father and Child Cohort Study
Hernáez Á, Wootton RE, Page CM, Skåra KH, Fraser A, Rogne T, Magnus P, Njølstad PR, Andreassen OA, Burgess S, Lawlor DA, Magnus MC. Smoking and infertility: multivariable regression and Mendelian randomization analyses in the Norwegian Mother, Father and Child Cohort Study. Fertility And Sterility 2022, 118: 180-190. PMID: 35562204, PMCID: PMC7612999, DOI: 10.1016/j.fertnstert.2022.04.001.Peer-Reviewed Original ResearchConceptsChild Cohort StudyCohort studySmoking intensityNorwegian MotherTobacco useMultivariable regressionGreater smoking intensityEffect of smokingHigher smoking intensityMendelian randomizationSelf-reported informationMendelian randomization analysisNationwide cohortProspective studySmoking cessationMendelian randomization resultsMAIN OUTCOMESmokingInfertilityTrue lackGenetic instrumentsRandomization analysisWomenMenRandomization resultsModifiable risk factors for ectopic pregnancy: a Mendelian randomization study
Rogne T, Liew Z, Hernáez Á, Brumpton BM, Magnus MC. Modifiable risk factors for ectopic pregnancy: a Mendelian randomization study. American Journal Of Obstetrics And Gynecology 2022, 227: 339-341.e4. PMID: 35390318, DOI: 10.1016/j.ajog.2022.03.063.Peer-Reviewed Original ResearchSystemic iron status and maternal pregnancy complications: a Mendelian randomization study
Rogne T, Burgess S, Gill D. Systemic iron status and maternal pregnancy complications: a Mendelian randomization study. International Journal Of Epidemiology 2022, 51: 1024-1027. PMID: 35234877, PMCID: PMC7614592, DOI: 10.1093/ije/dyac037.Peer-Reviewed Original Research
2021
Body mass index and subfertility: multivariable regression and Mendelian randomization analyses in the Norwegian Mother, Father and Child Cohort Study
Hernáez Á, Rogne T, Skåra KH, Håberg SE, Page CM, Fraser A, Burgess S, Lawlor DA, Magnus MC. Body mass index and subfertility: multivariable regression and Mendelian randomization analyses in the Norwegian Mother, Father and Child Cohort Study. Human Reproduction 2021, 36: 3141-3151. PMID: 34668019, PMCID: PMC8600658, DOI: 10.1093/humrep/deab224.Peer-Reviewed Original ResearchConceptsCohort studyBMI valuesMendelian randomization analysisMultivariable regressionGreater oddsMultivariable logistic regression modelSTUDY FUNDING/COMPETINGProject number 262700Risk of subfertilityRandomization analysisBody mass indexChild Cohort StudyPARTICIPANTS/MATERIALSUK National InstituteNational InstituteROLE OF CHANCELogistic regression modelsSelf-reported informationAssisted reproduction technologyObese menObese womenHigher BMILower BMIMass indexUS National InstitutesSemiquantitative Real-Time PCR to Distinguish Pneumocystis Pneumonia from Colonization in a Heterogeneous Population of HIV-Negative Immunocompromised Patients
Grønseth S, Rogne T, Hannula R, Åsvold BO, Afset JE, Damås JK. Semiquantitative Real-Time PCR to Distinguish Pneumocystis Pneumonia from Colonization in a Heterogeneous Population of HIV-Negative Immunocompromised Patients. Microbiology Spectrum 2021, 9: 10.1128/spectrum.00026-21. PMID: 34346746, PMCID: PMC8552647, DOI: 10.1128/spectrum.00026-21.Peer-Reviewed Original ResearchConceptsSemiquantitative real-time PCRPneumocystis pneumoniaReal-time PCRCutoff valuePCP statusHigher fungal loadHematological malignanciesPneumocystis jiroveciiHIV-negative immunocompromised patientsHuman immunodeficiency virus (HIV) infectionLower respiratory tract specimensRisk of PCPSolid organ transplant recipientsFungal loadHIV Pneumocystis pneumoniaImmunodeficiency virus infectionOrgan transplant recipientsSolid organ recipientsHIV-negative individualsPCR-positive patientsSolid organ transplantationRespiratory tract specimensVulnerable patient populationLife-threatening infectionsAcute respiratory syndromeEpidemiological and clinical characteristics of immunocompromised patients infected with Pneumocystis jirovecii in a twelve-year retrospective study from Norway
Grønseth S, Rogne T, Hannula R, Åsvold BO, Afset JE, Damås JK. Epidemiological and clinical characteristics of immunocompromised patients infected with Pneumocystis jirovecii in a twelve-year retrospective study from Norway. BMC Infectious Diseases 2021, 21: 659. PMID: 34233631, PMCID: PMC8262122, DOI: 10.1186/s12879-021-06144-1.Peer-Reviewed Original ResearchConceptsHuman immunodeficiency virusRegional incidence ratesRetrospective studyMedical recordsIncidence rateP. jiroveciiTwelve-year retrospective studyMain clinical findingsMajor risk factorPatients' medical recordsHospital mortalityImmunosuppressant usePCP prophylaxisClinical characteristicsMost patientsRadiological featuresPerson yearsClinical findingsImmunodeficiency virusIntensive carePolymerase chain reactionRisk factorsModern chemotherapyCardinal symptomsStudy populationRelationship Between Blood Pressure and Incident Cardiovascular Disease
Malik R, Georgakis MK, Vujkovic M, Damrauer SM, Elliott P, Karhunen V, Giontella A, Fava C, Hellwege JN, Shuey MM, Edwards TL, Rogne T, Åsvold BO, Brumpton BM, Burgess S, Dichgans M, Gill D. Relationship Between Blood Pressure and Incident Cardiovascular Disease. Hypertension 2021, 77: 2004-2013. PMID: 33813844, PMCID: PMC8115430, DOI: 10.1161/hypertensionaha.120.16534.Peer-Reviewed Original ResearchGWAS Identifies LINC01184/SLC12A2 as a Risk Locus for Skin and Soft Tissue Infections
Rogne T, Liyanarachi KV, Rasheed H, Thomas LF, Flatby HM, Stenvik J, Løset M, Gill D, Burgess S, Willer CJ, Hveem K, Åsvold BO, Brumpton BM, DeWan AT, Solligård E, Damås JK. GWAS Identifies LINC01184/SLC12A2 as a Risk Locus for Skin and Soft Tissue Infections. Journal Of Investigative Dermatology 2021, 141: 2083-2086.e8. PMID: 33662382, PMCID: PMC7612997, DOI: 10.1016/j.jid.2021.01.020.Peer-Reviewed Original Research
2020
Body mass index and risk of dying from a bloodstream infection: A Mendelian randomization study
Rogne T, Solligård E, Burgess S, Brumpton BM, Paulsen J, Prescott HC, Mohus RM, Gustad LT, Mehl A, Åsvold BO, DeWan AT, Damås JK. Body mass index and risk of dying from a bloodstream infection: A Mendelian randomization study. PLOS Medicine 2020, 17: e1003413. PMID: 33196656, PMCID: PMC7668585, DOI: 10.1371/journal.pmed.1003413.Peer-Reviewed Original ResearchConceptsBody mass indexHigher body mass indexBloodstream infectionsBSI incidenceBSI mortalityHazard ratioMass indexGeneral populationPopulation-based cohortAnalysis of patientsTerms of mortalityMendelian randomization studyTraditional epidemiological studiesMendelian randomization analysisObesity paradoxMean ageObservational studyEpidemiological studiesRandomization studyCausal associationSepsisMortalityPatientsInfectionRandomization analysisGenome-Wide Linkage Analysis of the Risk of Contracting a Bloodstream Infection in 47 Pedigrees Followed for 23 Years Assembled From a Population-Based Cohort (the HUNT Study).
Rogne T, Damås JK, Solligård E, DeWan AT. Genome-Wide Linkage Analysis of the Risk of Contracting a Bloodstream Infection in 47 Pedigrees Followed for 23 Years Assembled From a Population-Based Cohort (the HUNT Study). Critical Care Medicine 2020, 48: 1580-1586. PMID: 32885941, DOI: 10.1097/ccm.0000000000004520.Peer-Reviewed Original Research
2019
Presenting complaints and mortality in a cohort of 22 000 adult emergency patients at a local hospital in Nepal
Giri S, Rogne T, Uleberg O, Skovlund E, Shrestha SK, Koju R, Damås JK, Solligård E, Risnes KR. Presenting complaints and mortality in a cohort of 22 000 adult emergency patients at a local hospital in Nepal. Journal Of Global Health 2019, 9: 020403. PMID: 31489186, PMCID: PMC6708590, DOI: 10.7189/jogh.09.020403.Peer-Reviewed Original ResearchConceptsLow-resource settingsEmergency departmentAdult emergency patientsPost-discharge mortalityChronic lung diseaseEmergency department populationHealth carePrimary health careEmergency health care systemHealth care needsPost-discharge studyHealth care systemEmergency health careAbdominal complaintsED dischargeAdult patientsMedian ageLung diseaseAppropriate followSex distributionEmergency patientsLocal hospitalCare needsPatientsHigh mortality
2018
Rate of avoidable deaths in a Norwegian hospital trust as judged by retrospective chart review
Rogne T, Nordseth T, Marhaug G, Berg EM, Tromsdal A, Sæther O, Gisvold S, Hatlen P, Hogan H, Solligård E. Rate of avoidable deaths in a Norwegian hospital trust as judged by retrospective chart review. BMJ Quality & Safety 2018, 28: 49. PMID: 30026281, DOI: 10.1136/bmjqs-2018-008053.Peer-Reviewed Original ResearchConceptsHospital deathAvoidable deathsNorwegian hospital trustMandatory reporting systemRetrospective case record reviewHospital trustsRetrospective chart reviewHigh-risk populationCase record reviewReporting systemUnselected sampleChart reviewRecord reviewDeath groupSurgical departmentUnselected populationSuch deathsPatientsHealth policyDeathLife expectancyRegular reviewReport systemGreater proportionReview