2000
Neurons in Layer III of the Entorhinal Cortex: A Role in Epileptogenesis and Epilepsy?
SCHWARCZ R, EID T, DU F. Neurons in Layer III of the Entorhinal Cortex: A Role in Epileptogenesis and Epilepsy? Annals Of The New York Academy Of Sciences 2000, 911: 328-342. PMID: 10911883, DOI: 10.1111/j.1749-6632.2000.tb06735.x.Peer-Reviewed Original ResearchConceptsTemporal lobe epilepsyEntorhinal cortexLayer IIILobe epilepsySeizure-induced cell deathProminent excitatory inputSeizure-induced deathLayer III neuronsAminooxyacetic acidAOAA injectionPreferential lesionGABAergic neuronsNeuron lossLimbic structuresExcitatory inputsPathological changesParahippocampal structuresAnimal modelsEpilepsyNeuronsLesionsCell deathCortexDeathInjection
1995
Differential neuronal vulnerability to amino-oxyacetate and quinolinate in the rat parahippocampal region
Eid T, Du F, Schwarcz R. Differential neuronal vulnerability to amino-oxyacetate and quinolinate in the rat parahippocampal region. Neuroscience 1995, 68: 645-656. PMID: 8577365, DOI: 10.1016/0306-4522(95)00183-j.Peer-Reviewed Original ResearchConceptsAcute behavioral seizuresBehavioral seizuresDizocilpine maleateNeuronal lossEntorhinal cortexEndogenous N-methyl-D-aspartate receptor agonistN-methyl-D-aspartate receptor antagonist dizocilpine maleateLayer IIIN-methyl-D-aspartate receptor agonistParahippocampal regionN-methyl-D-aspartate (NMDA) receptor subtypeDifferential neuronal vulnerabilityDorsal perirhinal cortexPreferential neuronal lossTemporal lobe epilepsyChloral hydrate anesthesiaLower anesthetic doseNeuropathological sequelaeLobe epilepsyNeuropathological changesLayer VNeuronal vulnerabilityPreferential degenerationAnesthetic doseReceptor agonist