2021
Network-Related Changes in Neurotransmitters and Seizure Propagation During Rodent Epileptogenesis
Dhaher R, Gruenbaum SE, Sandhu MRS, Ottestad-Hansen S, Tu N, Wang Y, Lee TW, Deshpande K, Spencer DD, Danbolt NC, Zaveri HP, Eid T. Network-Related Changes in Neurotransmitters and Seizure Propagation During Rodent Epileptogenesis. Neurology 2021, 96: e2261-e2271. PMID: 33722994, PMCID: PMC8166437, DOI: 10.1212/wnl.0000000000011846.Peer-Reviewed Original ResearchConceptsSpontaneous seizuresSeizure propagationSeizure focusMesial temporal lobe epilepsyExtracellular brain levelsTemporal lobe epilepsyExtracellular glutamate levelsRelevant rodent modelsGlutamine synthetase inhibitor methionine sulfoximineTransporter subtype 1Contralateral hippocampusLobe epilepsyBrain levelsBrain microdialysisExtracellular GABANeurotransmitter levelsSeizure initiationGlutamate levelsSeizure onsetEpilepsy networkRodent modelsSubtype 1EpileptogenesisHippocampusBrain regions
2018
5 Oral Administration of Branched-Chain Amino Acids Results in Increased Seizure Threshold and Loss of Hippocampal Neurons in a Rodent Model of Mesial Temporal Lobe Epilepsy
Gruenbaum S, Dhaher R, Rapuano A, Tang A, Eid T. 5 Oral Administration of Branched-Chain Amino Acids Results in Increased Seizure Threshold and Loss of Hippocampal Neurons in a Rodent Model of Mesial Temporal Lobe Epilepsy. American Journal Of Clinical Pathology 2018, 149: s165-s166. DOI: 10.1093/ajcp/aqx149.374.Peer-Reviewed Original ResearchMesial temporal lobe epilepsyTemporal lobe epilepsyBCAA ingestionSeizure thresholdSpontaneous seizuresDays of drinkingRodent modelsLobe epilepsyDentate hilusControl ratsControl groupHilar neuron lossIncreased seizure thresholdInjection of pentylenetetrazoleSingle intraperitoneal injectionRight dentate gyrusRelevant rodent modelsGlutamine synthetase inhibitor methionine sulfoximineBranched-chain amino acid leucineBCAA groupInduced seizuresOral supplementationNeuron lossEpileptic ratsDentate gyrus