2024
Patterns of CNS Failures in Relapse/Refractory Large B-Cell Lymphoma (LBCL) Patients with Secondary CNS Disease Following Chimeric Antigen Receptor T-Cell (CAR T) Therapy
Nakashima J, Khatri V, Cruz-Chamorro R, Zhou J, Patra P, Gaballa S, Khimani F, Mirza S, Shah B, Saeed H, Chavez J, Locke F, Nishihori T, Liu H, Dong N, Lazaryan A, Robinson T, Freeman C, Jain M, Figura N. Patterns of CNS Failures in Relapse/Refractory Large B-Cell Lymphoma (LBCL) Patients with Secondary CNS Disease Following Chimeric Antigen Receptor T-Cell (CAR T) Therapy. International Journal Of Radiation Oncology • Biology • Physics 2024, 120: e646-e647. DOI: 10.1016/j.ijrobp.2024.07.1421.Peer-Reviewed Original ResearchLarge B-cell lymphomaSecondary CNS lymphomaB-cell lymphomaCNS failureCNS recurrenceCNS diseaseCNS lymphomaCAR-TOverall survivalBridging therapyCNS diagnosisRelapsed/refractory large B-cell lymphomaChimeric antigen receptor T cellsCAR-T cell trialsPattern of failure analysisCAR-T cell therapyMedian age of patientsClinical outcomes of patientsCNS-only progressionSystemic disease recurrenceT-cell therapyCAR-T therapyCytokine-release syndromePatterns of recurrenceKaplan-Meier method
2023
CD19 Intron Retention Is Mechanism of CAR-T Treatment Resistance in Non-Hodgkin Lymphoma
Noble J, Locke F, Savid-Frontera C, Jain M, Turner J, Miranda J, Madanayake T, Naderinezhad S, Corallo S, Menges M, Reid K, Robinson T. CD19 Intron Retention Is Mechanism of CAR-T Treatment Resistance in Non-Hodgkin Lymphoma. Blood 2023, 142: 3506. DOI: 10.1182/blood-2023-185074.Peer-Reviewed Original ResearchNon-durable responseProgression free survivalSurface protein expressionB-cell acute lymphoblastic leukemiaCAR-TCAR-T treatmentFlow cytometryProtein expressionFree survivalCell linesWestern blottingRefractory diffuse large B-cell lymphomaMedian expressionChimeric antigen receptor T cellsJeKo-1Associated with progression free survivalDiffuse large B-cell lymphomaPre-treatment tumor biopsiesPre-treatment tumor samplesLarge B-cell lymphomaIntron 2CAR-T failureCD19 surface expressionR/R DLBCL patientsIntron 6