2013
Heart Failure in Hypophosphatemic Rickets: Complications from High-Dose Phosphate Therapy
Sun GE, Suer O, Carpenter TO, Tan CD, Li-Ng M. Heart Failure in Hypophosphatemic Rickets: Complications from High-Dose Phosphate Therapy. Endocrine Practice 2013, 19: e8-e11. PMID: 23186962, DOI: 10.4158/ep12184.cr.Peer-Reviewed Original ResearchConceptsYears of ageHypophosphatemic ricketsPhosphate therapyTertiary hyperparathyroidismHeart failureCardiac calcificationSevere calcific coronary artery diseaseCalcific coronary artery diseaseAortic valve replacementCoronary artery calcificationCongestive heart failureCoronary artery diseaseManagement of patientsHeart valve calcificationImplantable cardioverter defibrillatorPathophysiology of calcificationCalcitriol useCardiac complicationsArtery calcificationRenal failureValve replacementArtery diseaseClinical courseAppropriate therapyHeart block
2008
A translocation causing increased α-Klotho level results in hypophosphatemic rickets and hyperparathyroidism
Brownstein CA, Adler F, Nelson-Williams C, Iijima J, Li P, Imura A, Nabeshima Y, Reyes-Mugica M, Carpenter TO, Lifton RP. A translocation causing increased α-Klotho level results in hypophosphatemic rickets and hyperparathyroidism. Proceedings Of The National Academy Of Sciences Of The United States Of America 2008, 105: 3455-3460. PMID: 18308935, PMCID: PMC2265125, DOI: 10.1073/pnas.0712361105.Peer-Reviewed Original ResearchConceptsHypophosphatemic ricketsAlpha-KlothoExcessive renal lossPhosphate levelsParathyroid massRenal failureRenal osteodystrophyFGF23 levelsMajor complicationsParathyroid hyperplasiaKidney failureRenal lossBeta-glucuronidase activityNormal responseHyperparathyroidismEnergy homeostasisRicketsBone formationSkeletal abnormalitiesPhysiologic processesPhosphate homeostasisHyperphosphatemiaPatientsHyperplasiaBone defects
1986
Progressive tubulointerstitial renal disease in infancy with associated hepatic abnormalities
Harris H, Carpenter T, Shanley P, Rosen S, Levey R, Harmon W. Progressive tubulointerstitial renal disease in infancy with associated hepatic abnormalities. The American Journal Of Medicine 1986, 81: 169-176. PMID: 3524222, DOI: 10.1016/0002-9343(86)90205-6.Peer-Reviewed Original ResearchConceptsHepatic abnormalitiesInfantile polycystic kidney diseaseSignificant renal insufficiencyTubulointerstitial renal diseaseBile duct proliferationProgressive renal failurePolycystic kidney diseaseRenal Fanconi syndromeRenal insufficiencyRenal transplantTubulointerstitial injuryPortal fibrosisRenal failureRenal diseaseDuct proliferationClinical evidenceFat malabsorptionRenal lesionsKidney diseaseHepatic fibrosisMale infantRenal disordersFanconi syndromeMorphologic featuresDiagnostic categories
1985
Serum osteocalcin concentrations in children with metabolic bone disease
Cole D, Carpenter T, Gundberg C. Serum osteocalcin concentrations in children with metabolic bone disease. The Journal Of Pediatrics 1985, 106: 770-776. PMID: 3873533, DOI: 10.1016/s0022-3476(85)80351-6.Peer-Reviewed Original ResearchConceptsMetabolic bone diseaseBone diseaseRenal failureSerum osteocalcinBone metabolismSerum osteocalcin valuesMean serum concentrationSerum osteocalcin concentrationYears of ageForms of ricketsPubertal growth spurtBlood osteocalcinSubacute changesApgar scoreRenal functionPeritoneal dialysisSerum levelsPatient populationSerum concentrationsOsteocalcin levelsRenal clearanceOsteocalcin concentrationsOsteocalcin valuesUseful markerVitamin K