2013
Adaptation Dynamics in Densely Clustered Chemoreceptors
Pontius W, Sneddon MW, Emonet T. Adaptation Dynamics in Densely Clustered Chemoreceptors. PLOS Computational Biology 2013, 9: e1003230. PMID: 24068908, PMCID: PMC3777915, DOI: 10.1371/journal.pcbi.1003230.Peer-Reviewed Original ResearchConceptsOrganisms senseChemotaxis pathwayTransmembrane receptorsNutrient gradientsReceptor methylationProtein abundanceReceptor substrateBacterial chemotaxisReceptor activityModification systemPathway constituentsEscherichia coliIndividual cellsEnvironmental stimuliFunctional robustnessExpression levelsMechanistic relationshipEnzymeModel systemEnzyme kineticsChemotaxis systemPrecise adaptationAdaptation dynamicsReceptor modificationModification kinetics
2010
Single‐cell quantification of IL‐2 response by effector and regulatory T cells reveals critical plasticity in immune response
Feinerman O, Jentsch G, Tkach KE, Coward JW, Hathorn MM, Sneddon MW, Emonet T, Smith KA, Altan-Bonnet G. Single‐cell quantification of IL‐2 response by effector and regulatory T cells reveals critical plasticity in immune response. Molecular Systems Biology 2010, 6: msb201090. PMID: 21119631, PMCID: PMC3010113, DOI: 10.1038/msb.2010.90.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCells, CulturedCoculture TechniquesEnzyme-Linked Immunosorbent AssayImmunity, CellularInterleukin-2Interleukin-2 Receptor alpha SubunitMiceMice, Inbred C57BLMice, TransgenicModels, BiologicalSingle-Cell AnalysisStaining and LabelingT-Lymphocytes, Helper-InducerT-Lymphocytes, RegulatoryConceptsInterleukin-2T cellsImmune responseSingle-cell quantificationSingle-cell measurementsEffector T cellsRegulatory T cellsIL-2 responseSurvival signalsReceptor expression levelsIndividual cellsSuppressive capacityCytokine regulationExpression levelsImmune systemHeterogeneous cellsSpecific suppressionSilico modelingPopulation levelCellsEffectorsResponseCritical plasticityPopulationSuppression