2024
Feasibility of In-Hospital Administration of a Tool to Predict Persistent Post-ICU Functional Impairment Among Older ICU Survivors A Pilot Study
Stevenson J, Murphy T, Tessier-Sherman B, Pisani M, Gill T, Ferrante L. Feasibility of In-Hospital Administration of a Tool to Predict Persistent Post-ICU Functional Impairment Among Older ICU Survivors A Pilot Study. CHEST Critical Care 2024, 2: 100093. DOI: 10.1016/j.chstcc.2024.100093.Peer-Reviewed Original ResearchRisk prediction toolsICU survivorsIn-hospital administrationOlder adultsFunctional impairmentPilot studyIn-hospital mobilityOlder ICU survivorsDevelopment of risk prediction modelsHospital-related factorsIn-hospital factorsPresence of deliriumRisk prediction modelModel discriminationPersistent functional impairmentStatistical significanceHospital settingStudy designFeasibility thresholdDaily activitiesIncreased riskInternational Consensus ConferenceConsensus conferenceSurvivorsCritical illness“Faith and a sunny day”: Association of patient frailty with strain experienced by informal caregivers of older adults with non-muscle-invasive bladder cancer
Garg T, Maheshwari C, Frank K, Johns A, Rabinowitz K, Danella J, Becker H, Kirchner H, Nielsen M, Cohen H, Murphy T, McMullen C. “Faith and a sunny day”: Association of patient frailty with strain experienced by informal caregivers of older adults with non-muscle-invasive bladder cancer. Journal Of Geriatric Oncology 2024, 15: 102060. PMID: 39244892, PMCID: PMC11560472, DOI: 10.1016/j.jgo.2024.102060.Peer-Reviewed Original ResearchCaregiver Strain IndexDeficit accumulation indexInformal caregiversOlder adultsCaregiver strainInformal caregivers of older adultsCaregivers of older adultsAging-related conditionsCoping strategiesQualitative thematic content analysisDyads of older adultsCross-sectional survey studyConditions of older adultsInformal caregiver strainMultivariable negative binomial regressionThematic content analysisMeasures of frailtyCross-sectional studyNegative binomial regressionNon-muscle-invasive bladder cancerPre-frailSocial supportCaregiversSelf-report measuresGeriatric assessmentIn-Hospital Delirium and Disability and Cognitive Impairment After COVID-19 Hospitalization
Kaushik R, McAvay G, Murphy T, Acampora D, Araujo K, Charpentier P, Chattopadhyay S, Geda M, Gill T, Kaminski T, Lee S, Li J, Cohen A, Hajduk A, Ferrante L. In-Hospital Delirium and Disability and Cognitive Impairment After COVID-19 Hospitalization. JAMA Network Open 2024, 7: e2419640. PMID: 38954414, PMCID: PMC11220565, DOI: 10.1001/jamanetworkopen.2024.19640.Peer-Reviewed Original ResearchConceptsIn-hospital deliriumChart-Based Delirium Identification InstrumentOlder adultsFunctional disabilityCOVID-19 hospitalizationCognitive impairmentCohort studyAssociated with increased functional disabilityHospitalized older adultsIncreased functional disabilityAssociation of deliriumPostdischarge follow-upRisk of deliriumTertiary care systemFollow-upPresence of cognitive impairmentProspective cohort studyLogistic regression modelsOlder survivorsCare systemIncreasing cognitive impairmentMain OutcomesCOVID-19Hospital dischargePrimary outcomeSocial Determinants of Health and Delivery of Rehabilitation to Older Adults During ICU Hospitalization
Jain S, Murphy T, Falvey J, Leo-Summers L, O’Leary J, Zang E, Gill T, Krumholz H, Ferrante L. Social Determinants of Health and Delivery of Rehabilitation to Older Adults During ICU Hospitalization. JAMA Network Open 2024, 7: e2410713. PMID: 38728030, PMCID: PMC11087837, DOI: 10.1001/jamanetworkopen.2024.10713.Peer-Reviewed Original ResearchConceptsSocial determinants of healthDeterminants of healthOccupational therapyPhysical therapyOlder adultsRural residentsIntensive care unit hospitalizationRehabilitation deliveryIntensive care unitSocial determinantsSocioeconomic disadvantageNational Health and Aging Trends StudyDelivery of physical therapyIllness hospitalizationFactors associated with lower oddsDelivery of rehabilitationIn-hospital rehabilitationMitigate functional declineMedicaid eligibilityBurden of disabilityHigh school educationDual MedicareTrends StudyMedicare claimsLength of stay
2023
Acute hospital use in older adults following the 2015 Dutch reform of long-term care: an interrupted time series analysis
Wammes J, Bakx P, Wouterse B, Buurman B, Murphy T, Vroomen J. Acute hospital use in older adults following the 2015 Dutch reform of long-term care: an interrupted time series analysis. The Lancet Healthy Longevity 2023, 4: e257-e264. PMID: 37269863, PMCID: PMC10316520, DOI: 10.1016/s2666-7568(23)00064-8.Peer-Reviewed Original ResearchConceptsIncident rate ratiosInterrupted time series analysisHospital dataOlder adultsAcute hospitalisationAcute hospital useAverage hospital lengthNational hospital dataMonthly rateLong-term careSupplementary Materials sectionAdvancing Translational SciencesHospital lengthHospital admissionAverage LOSLTC reformHospitalisationCurative careHospital useLongitudinal increaseRate ratioMedical specialistsNational InstituteAdultsLOSSocial Vulnerability and Delivery of In-hospital Rehabilitation Services to Older Adults With Critical Illness
Jain S, Murphy T, O'Leary Jr J, Leo-Summers L, Zang E, Falvey J, Gill T, Krumholz H, Ferrante L. Social Vulnerability and Delivery of In-hospital Rehabilitation Services to Older Adults With Critical Illness. 2023, a2889-a2889. DOI: 10.1164/ajrccm-conference.2023.207.1_meetingabstracts.a2889.Peer-Reviewed Original Research
2022
GERONTOLOGIC BIOSTATISTICS: MERGING WITH DATA SCIENCE AND TOWARD PERSONALIZED MEDICINE
Shardell M, Murphy T, Allore H. GERONTOLOGIC BIOSTATISTICS: MERGING WITH DATA SCIENCE AND TOWARD PERSONALIZED MEDICINE. Innovation In Aging 2022, 6: 177-177. PMCID: PMC9770254, DOI: 10.1093/geroni/igac059.708.Peer-Reviewed Original ResearchStudy of older personsEpidemiology of agingHealth-related interventionsAssessment of healthHeterogeneity of treatment effectsOlder personsOlder adultsIndividual sessionsTreatment effectsOlder patientsMultifactorial naturePublished studiesData scienceSessionsMultiple streams of dataStreams of dataMultimodal approachPersonalized medicineProgressive deteriorationIntegration of data scienceBehavioral phenotypesPatientsAgeInteractive visualizationPracticeA risk model for decline in health status after acute myocardial infarction among older adults
Hajduk A, Dodson J, Murphy T, Chaudhry S. A risk model for decline in health status after acute myocardial infarction among older adults. Journal Of The American Geriatrics Society 2022, 71: 1228-1235. PMID: 36519774, PMCID: PMC10089939, DOI: 10.1111/jgs.18162.Peer-Reviewed Original ResearchConceptsAcute myocardial infarctionHealth status declineImportant patient-centered outcomesPatient-centered outcomesMyocardial infarctionStatus declineHealth statusOlder adultsShort Form-12 Physical Component ScorePhysical component scoreProspective cohort studyRisk prediction modelLogistic regression modelsOlder adult survivorsPredictive risk modelRisk modelCohort studyPatient ageValidation cohortC-statisticRisk factorsHigh riskLower riskAdult survivorsHospitalizationFactors Associated with Disability Over the 6 Months After a COVID Hospitalization Among Older Adults: The VALIANT (CO V ID-19 in Older A dults: A L ong i tudinal A ssessme nt ) Study
Ferrante L, Hajduk A, Cohen A, McAvay G, Geda M, Chattopadhyay S, Lee S, Acampora D, Gill T, Murphy T. Factors Associated with Disability Over the 6 Months After a COVID Hospitalization Among Older Adults: The VALIANT (CO V ID-19 in Older A dults: A L ong i tudinal A ssessme nt ) Study. 2022, a3696-a3696. DOI: 10.1164/ajrccm-conference.2022.205.1_meetingabstracts.a3696.Peer-Reviewed Original Research
2021
The Effect of Socioeconomic Disadvantage on Development of Functional Decline Following Critical Illness Among Older Adults
Jain S, Murphy T, O'Leary J, Leo-Summers L, Ferrante L. The Effect of Socioeconomic Disadvantage on Development of Functional Decline Following Critical Illness Among Older Adults. 2021, a1214-a1214. DOI: 10.1164/ajrccm-conference.2021.203.1_meetingabstracts.a1214.Peer-Reviewed Original Research
2019
SPOUSAL ASSOCIATIONS IN MONTHLY REPORTS OF DISABILITY IN THE PRECIPITATING EVENTS PROJECT
Monin J, Laws H, Gahbauer E, Murphy T, Gill T. SPOUSAL ASSOCIATIONS IN MONTHLY REPORTS OF DISABILITY IN THE PRECIPITATING EVENTS PROJECT. Innovation In Aging 2019, 3: s672-s672. PMCID: PMC6845752, DOI: 10.1093/geroni/igz038.2484.Peer-Reviewed Original ResearchPrecipitating Events ProjectDisability levelSubsequent disabilitySpousal associationsSelf-reported disabilityAdults age 70Actor-partner interdependence modelFunctional statusPrior disabilityDaily livingOngoing longitudinal studyAge 70Monthly reportsOlder adultsLongitudinal actor-partner interdependence modelMonthly assessmentsDisabilityLongitudinal studySpouse's levelAssociationPartner Interdependence ModelOutcomesSubsequent increasePartner influenceIntimate partners
2011
Bayesian hierarchical modeling for a non‐randomized, longitudinal fall prevention trial with spatially correlated observations
Murphy TE, Allore HG, Leo‐Summers L, Carlin BP. Bayesian hierarchical modeling for a non‐randomized, longitudinal fall prevention trial with spatially correlated observations. Statistics In Medicine 2011, 30: 522-530. PMID: 21294148, PMCID: PMC3477673, DOI: 10.1002/sim.3912.Peer-Reviewed Original ResearchMeSH KeywordsAccidental FallsAgedAged, 80 and overAlgorithmsBayes TheoremComputer SimulationConnecticutControlled Clinical Trials as TopicEmergency Medical ServicesFemaleHumansLongitudinal StudiesMaleMarkov ChainsModels, StatisticalMonte Carlo MethodPatient Education as TopicPoisson DistributionTreatment OutcomeConceptsNon-randomized designFall prevention trialsPersons 70 yearsCommunity-based health interventionsNon-randomized interventionsRandomization of participantsInjurious fallsPrevention trialsEmergency departmentFall preventionInterventional effectsLongitudinal trialCare areasConnecticut CollaborationHealth interventionsInterventional designHealthcare interventionsMedicaid ServicesOlder adultsIntervention areaSerious injuriesZip codesTrialsInterventionInfluential covariates