2016
Default-Mode Network Abnormalities in Pediatric Posttraumatic Stress Disorder
Patriat R, Birn RM, Keding TJ, Herringa RJ. Default-Mode Network Abnormalities in Pediatric Posttraumatic Stress Disorder. Journal Of The American Academy Of Child & Adolescent Psychiatry 2016, 55: 319-327. PMID: 27015723, PMCID: PMC4808564, DOI: 10.1016/j.jaac.2016.01.010.Peer-Reviewed Original ResearchConceptsPediatric posttraumatic stress disorderPosttraumatic stress disorderTask-positive networkAttentional control networkRe-experiencing symptomsDefault mode network abnormalitiesGreater anticorrelationStress disorderDMN connectivityAdult posttraumatic stress disorderFunctional magnetic resonance imaging studyLarge-scale network abnormalitiesTrauma-related thoughtsNetwork abnormalitiesControl networkResting-state functional magnetic resonance imaging studyPrefrontal cortex connectivityIndependent component analysisSeed-based connectivityMagnetic resonance imaging studyAutobiographical memoryResonance imaging studyCortex connectivityHealthy youthNeurodevelopmental factors
2014
Abnormal Structure of Fear Circuitry in Pediatric Post-Traumatic Stress Disorder
Keding TJ, Herringa RJ. Abnormal Structure of Fear Circuitry in Pediatric Post-Traumatic Stress Disorder. Neuropsychopharmacology 2014, 40: 537-545. PMID: 25212487, PMCID: PMC4289962, DOI: 10.1038/npp.2014.239.Peer-Reviewed Original ResearchConceptsGray matter volumeHippocampal volumeAge-related differencesPediatric PTSDHealthy youthPediatric post-traumatic stress disorderPTSD youthPrefrontal cortexStructural brain studiesSubgenual anterior cingulate cortexAge-dependent effectsAmygdala/hippocampusPost-traumatic stress disorderAnatomical brain MRIAnterior cingulate cortexRight anterior hippocampusMedial prefrontal cortexAbnormal structureHigh-resolution MRIPTSD durationCross-sectional designOverall group differencesNeurotoxic processesRe-experiencing symptomsBrain MRI