2021
Longitudinal hippocampal circuit change differentiates persistence and remission of pediatric posttraumatic stress disorder
George G, Keding T, Heyn S, Herringa R. Longitudinal hippocampal circuit change differentiates persistence and remission of pediatric posttraumatic stress disorder. Depression And Anxiety 2021, 39: 8-18. PMID: 34843625, PMCID: PMC8763137, DOI: 10.1002/da.23229.Peer-Reviewed Original ResearchConceptsPediatric posttraumatic stress disorderFunctional magnetic resonance imagingPosttraumatic stress disorderTD youthHippocampal activationStress disorderFunctional connectivityEmotional processing taskFunctional brain substratesHippocampal functional connectivityFunctional connectivity analysisFunctional brain abnormalitiesPTSD youthEmotion processingThreat stimuliNeutral imagesPediatric PTSDBrain substratesPTSD groupActivation findingsConnectivity analysisProcessing tasksVisual cortexLongitudinal studyYouth
2016
Paradoxical Prefrontal–Amygdala Recruitment to Angry and Happy Expressions in Pediatric Posttraumatic Stress Disorder
Keding TJ, Herringa RJ. Paradoxical Prefrontal–Amygdala Recruitment to Angry and Happy Expressions in Pediatric Posttraumatic Stress Disorder. Neuropsychopharmacology 2016, 41: 2903-2912. PMID: 27329685, PMCID: PMC5061882, DOI: 10.1038/npp.2016.104.Peer-Reviewed Original ResearchConceptsPediatric posttraumatic stress disorderPediatric PTSDPosttraumatic stress disorderAngry facesPTSD youthHappy facesMedial prefrontal cortexHealthy youthEmotional facesEmotional expressionStress disorderCross-sectional age-related differencesImplicit emotional faceThreat-related emotionsPositive emotional expressionEmotion processing circuitryTrauma-related psychopathologyEmotional faces taskAbnormal neural responsesPrefrontal-amygdala circuitsWhole-brain analysisAmygdala/hippocampusAge-related differencesAge-related findingsEmotion interaction
2014
Abnormal Structure of Fear Circuitry in Pediatric Post-Traumatic Stress Disorder
Keding TJ, Herringa RJ. Abnormal Structure of Fear Circuitry in Pediatric Post-Traumatic Stress Disorder. Neuropsychopharmacology 2014, 40: 537-545. PMID: 25212487, PMCID: PMC4289962, DOI: 10.1038/npp.2014.239.Peer-Reviewed Original ResearchConceptsGray matter volumeHippocampal volumeAge-related differencesPediatric PTSDHealthy youthPediatric post-traumatic stress disorderPTSD youthPrefrontal cortexStructural brain studiesSubgenual anterior cingulate cortexAge-dependent effectsAmygdala/hippocampusPost-traumatic stress disorderAnatomical brain MRIAnterior cingulate cortexRight anterior hippocampusMedial prefrontal cortexAbnormal structureHigh-resolution MRIPTSD durationCross-sectional designOverall group differencesNeurotoxic processesRe-experiencing symptomsBrain MRI