2021
Differential DNA Methylation Is Associated With Hippocampal Abnormalities in Pediatric Posttraumatic Stress Disorder
Ensink JBM, Keding TJ, Henneman P, Venema A, Papale LA, Alisch RS, Westerman Y, van Wingen G, Zantvoord J, Middeldorp CM, Mannens MMAM, Herringa RJ, Lindauer R. Differential DNA Methylation Is Associated With Hippocampal Abnormalities in Pediatric Posttraumatic Stress Disorder. Biological Psychiatry Cognitive Neuroscience And Neuroimaging 2021, 6: 1063-1070. PMID: 33964519, PMCID: PMC8568739, DOI: 10.1016/j.bpsc.2021.04.016.Peer-Reviewed Original ResearchConceptsPediatric posttraumatic stress disorderPosttraumatic stress disorderStress disorderNon-PTSD control groupAnterior hippocampal volumeDifferential DNA methylationMethylome-wide association studiesAltered gene expressionHippocampal abnormalitiesDutch cohortHippocampal volumeEpigenetic mechanismsDNA methylationU.S. cohortMethylation differencesTreatment targetsControl groupStructural neuroimaging measuresNeural abnormalitiesGene expressionStress responseAssociation studiesBiological pathwaysBrain structuresCohort
2014
Abnormal Structure of Fear Circuitry in Pediatric Post-Traumatic Stress Disorder
Keding TJ, Herringa RJ. Abnormal Structure of Fear Circuitry in Pediatric Post-Traumatic Stress Disorder. Neuropsychopharmacology 2014, 40: 537-545. PMID: 25212487, PMCID: PMC4289962, DOI: 10.1038/npp.2014.239.Peer-Reviewed Original ResearchConceptsGray matter volumeHippocampal volumeAge-related differencesPediatric PTSDHealthy youthPediatric post-traumatic stress disorderPTSD youthPrefrontal cortexStructural brain studiesSubgenual anterior cingulate cortexAge-dependent effectsAmygdala/hippocampusPost-traumatic stress disorderAnatomical brain MRIAnterior cingulate cortexRight anterior hippocampusMedial prefrontal cortexAbnormal structureHigh-resolution MRIPTSD durationCross-sectional designOverall group differencesNeurotoxic processesRe-experiencing symptomsBrain MRI