Diverging Effects of Violence Exposure and Psychiatric Symptoms on Amygdala-Prefrontal Maturation during Childhood and Adolescence
Keding T, Russell J, Zhu X, He Q, Li J, Herringa R. Diverging Effects of Violence Exposure and Psychiatric Symptoms on Amygdala-Prefrontal Maturation during Childhood and Adolescence. Biological Psychiatry Cognitive Neuroscience And Neuroimaging 2024 PMID: 39182725, DOI: 10.1016/j.bpsc.2024.08.003.Peer-Reviewed Original ResearchBasolateral amygdalaFunctional connectivityPsychiatric symptomsViolence exposureCircuit maturationOrbitofrontal cortex functional connectivityDevelopment of psychiatric symptomsResting-state functional connectivityEffects of violence exposureAmygdala-prefrontal cortexSeverity of psychopathologyBrain age gap estimationIncreased psychiatric symptomsPhiladelphia Neurodevelopmental CohortThreat appraisal processEffects of adversityExposure to violenceNeurobiological correlatesAssociated with delayed maturationBrain circuitryNeurodevelopmental mechanismsPsychiatric riskIndividual differencesNeurodevelopmental CohortAtypical neurodevelopment