2019
Analysis of the Impact of Antiretroviral Drug Changes on Survival of Patients with Advanced-Stage AIDS with Multidrug-Resistant HIV Infection
Ma R, Jung TH, Peduzzi PN, Brown ST, Kyriakides TC. Analysis of the Impact of Antiretroviral Drug Changes on Survival of Patients with Advanced-Stage AIDS with Multidrug-Resistant HIV Infection. Journal Of The International Association Of Providers Of AIDS Care (JIAPAC) 2019, 18: 2325958219849101. PMID: 31272313, PMCID: PMC6748500, DOI: 10.1177/2325958219849101.Peer-Reviewed Original ResearchConceptsDrug changesCox proportional hazards regression modelKaplan-Meier survival techniqueMultidrug-resistant HIV infectionProportional hazards regression modelsAdvanced-stage AIDSDrug regimen changesSurvival of patientsHazards regression modelsAntiretroviral clinical trialsClinical biomarker dataCause mortalityMedication changesARV regimenHIV infectionImproved survivalRegimen changeClinical outcomesNonclinical reasonsClinical trialsBiomarker changesTreatment historyMultidrug resistanceTherapy strategiesPatients
2011
Effect of Treatment Interruption and Intensification of Antiretroviral Therapy on Health-Related Quality of Life in Patients with Advanced HIV
Joyce VR, Barnett PG, Chow A, Bayoumi AM, Griffin SC, Sun H, Holodniy M, Brown ST, Kyriakides TC, Cameron DW, Youle M, Sculpher M, Anis AH, Owens DK. Effect of Treatment Interruption and Intensification of Antiretroviral Therapy on Health-Related Quality of Life in Patients with Advanced HIV. Medical Decision Making 2011, 32: 70-82. PMID: 21383086, DOI: 10.1177/0272989x10397615.Peer-Reviewed Original ResearchConceptsVisual analog scaleHIV patientsART intensificationTreatment interruptionClinical eventsMedical Outcomes Study HIV Health SurveyAdvanced HIV patientsAntiretroviral therapy interruptionMultiple treatment failuresTemporary treatment interruptionAdverse clinical eventsHealth-related qualityStandard ARTHealth Utilities IndexStandard gambleQuality of lifeAdvanced HIVART interruptionInferior HRQoLMDR HIVTherapy interruptionAntiretroviral therapyHIV cohortOpen labelHRQoL scores
2009
Health-Related Quality of Life in a Randomized Trial of Antiretroviral Therapy for Advanced HIV Disease
Joyce VR, Barnett PG, Bayoumi AM, Griffin SC, Kyriakides TC, Yu W, Sundaram V, Holodniy M, Brown ST, Cameron W, Youle M, Sculpher M, Anis AH, Owens DK. Health-Related Quality of Life in a Randomized Trial of Antiretroviral Therapy for Advanced HIV Disease. JAIDS Journal Of Acquired Immune Deficiency Syndromes 2009, 50: 27-36. PMID: 19295332, DOI: 10.1097/qai.0b013e31818ce6f3.Peer-Reviewed Original ResearchConceptsHealth Utilities Index Mark 3Treatment-experienced HIV patientsEQ-5DHIV patientsHRQoL scoresClinical variablesMedical Outcomes Study HIV Health SurveyEQ-5D visual analog scaleHealth statusStandard gamblePreference-based health-related qualityAdvanced HIV diseaseBaseline HRQOL scoresConcomitant medication useTreatment-experienced HIVCD4 cell countHIV viral loadHealth-related qualityVisual analog scaleVeterans Affairs hospitalEQ-5D VASCross-sectional studyPreference-based HRQOLQuality of lifeTime trade-off (TTO) technique
2004
Study conduct, monitoring and data management in a trinational trial: the OPTIMA model
Kyriakides TC, Babiker A, Singer J, Piaseczny M, Russo J. Study conduct, monitoring and data management in a trinational trial: the OPTIMA model. Clinical Trials 2004, 1: 277-281. PMID: 16279253, DOI: 10.1191/1740774504cn022oa.Peer-Reviewed Original Research