2019
Open versus Endovascular Repair of Abdominal Aortic Aneurysm
Lederle FA, Kyriakides TC, Stroupe KT, Freischlag JA, Padberg FT, Matsumura JS, Huo Z, Johnson GR. Open versus Endovascular Repair of Abdominal Aortic Aneurysm. New England Journal Of Medicine 2019, 380: 2126-2135. PMID: 31141634, DOI: 10.1056/nejmoa1715955.Peer-Reviewed Original ResearchConceptsEndovascular repair groupOpen repair groupEndovascular repairOpen repairOverall survivalAbdominal aortic aneurysmEuropean trialsAortic aneurysmLong-term overall survivalChronic obstructive lung diseaseWorse long-term outcomesAsymptomatic abdominal aortic aneurysmElective endovascular repairLow perioperative mortalityObstructive lung diseaseTraditional open repairAbdominal aortic aneurysms resultsLong-term outcomesLong-term resultsNumber of patientsLong-term survivalCause mortalityPerioperative mortalityPerioperative periodMore patientsAnalysis of the Impact of Antiretroviral Drug Changes on Survival of Patients with Advanced-Stage AIDS with Multidrug-Resistant HIV Infection
Ma R, Jung TH, Peduzzi PN, Brown ST, Kyriakides TC. Analysis of the Impact of Antiretroviral Drug Changes on Survival of Patients with Advanced-Stage AIDS with Multidrug-Resistant HIV Infection. Journal Of The International Association Of Providers Of AIDS Care (JIAPAC) 2019, 18: 2325958219849101. PMID: 31272313, PMCID: PMC6748500, DOI: 10.1177/2325958219849101.Peer-Reviewed Original ResearchConceptsDrug changesCox proportional hazards regression modelKaplan-Meier survival techniqueMultidrug-resistant HIV infectionProportional hazards regression modelsAdvanced-stage AIDSDrug regimen changesSurvival of patientsHazards regression modelsAntiretroviral clinical trialsClinical biomarker dataCause mortalityMedication changesARV regimenHIV infectionImproved survivalRegimen changeClinical outcomesNonclinical reasonsClinical trialsBiomarker changesTreatment historyMultidrug resistanceTherapy strategiesPatients
2012
Long-Term Comparison of Endovascular and Open Repair of Abdominal Aortic Aneurysm
Lederle FA, Freischlag JA, Kyriakides TC, Matsumura JS, Padberg FT, Kohler TR, Kougias P, Jean-Claude JM, Cikrit DF, Swanson KM. Long-Term Comparison of Endovascular and Open Repair of Abdominal Aortic Aneurysm. New England Journal Of Medicine 2012, 367: 1988-1997. PMID: 23171095, DOI: 10.1056/nejmoa1207481.Peer-Reviewed Original ResearchConceptsEndovascular repair groupOpen repair groupAbdominal aortic aneurysmYears of ageEndovascular repairOpen repairLong-term survivalAortic aneurysmSimilar long-term survivalAsymptomatic abdominal aortic aneurysmVeterans Affairs Medical CenterElective endovascular repairLong-term morbidityTraditional open repairType of treatmentCause mortalityPerioperative mortalityTime of registrationOlder patientsYounger patientsEndovascular approachPrimary outcomeAneurysm ruptureMedical CenterSurvival advantage