Intensity of Renal Support in Critically Ill Patients with Acute Kidney Injury
Palevsky P, Zhang J, O'Connor T, Chertow G, Crowley S, Choudhury D, Finkel K, Kellum J, Paganini E, Schein R, Smith M, Swanson K, Thompson B, Vijayan A, Watnick S, Star R, Peduzzi P. Intensity of Renal Support in Critically Ill Patients with Acute Kidney Injury. New England Journal Of Medicine 2008, 359: 7-20. PMID: 18492867, PMCID: PMC2574780, DOI: 10.1056/nejmoa0802639.Peer-Reviewed Original ResearchConceptsAcute kidney injuryRenal replacement therapyNonrenal organ failureContinuous venovenous hemodiafiltrationIntensive treatment strategiesKidney injuryIll patientsIntensive therapyIntermittent hemodialysisKidney functionOrgan failureRenal supportTreatment strategiesContinuous renal replacement therapyDay 60Intensive renal replacement therapyIntensive renal supportLow-efficiency dialysisCritically Ill PatientsPrimary end pointHemodialysis three timesRate of deathNonrenal organsBaseline characteristicsStable patientsLessons for Successful Study Enrollment from the Veterans Affairs/National Institutes of Health Acute Renal Failure Trial Network Study
Crowley ST, Chertow GM, Vitale J, O'Connor T, Zhang J, Schein RM, Choudhury D, Finkel K, Vijayan A, Paganini E, Palevsky PM, Group F. Lessons for Successful Study Enrollment from the Veterans Affairs/National Institutes of Health Acute Renal Failure Trial Network Study. Clinical Journal Of The American Society Of Nephrology 2008, 3: 955-961. PMID: 18385390, PMCID: PMC2440269, DOI: 10.2215/cjn.05621207.Peer-Reviewed Original ResearchMeSH KeywordsAcute Kidney InjuryBiasClinical Trials as TopicCritical IllnessHemodiafiltrationHumansInformed ConsentIntensive Care UnitsMulticenter Studies as TopicNational Institutes of Health (U.S.)Patient SelectionRandomized Controlled Trials as TopicRenal DialysisResearch DesignTreatment OutcomeUnited StatesUnited States Department of Veterans AffairsConceptsHealth Acute Renal Failure Trial Network studyAcute Renal Failure Trial Network studyVeterans Affairs/National InstitutesAcute kidney injuryEnrollment windowKidney injuryPhysician refusalPotential patientsChronic kidney diseaseRenal replacement therapyNational InstituteEnrollment efficiencyLoss of patientsEligible patientsUnderlying comorbiditiesIll patientsStudy enrollmentKidney diseaseReplacement therapyFuture trialsIntervention trialsClinical equipoiseChronic illnessClinical trialsInclusion criteria