2022
Generalizability of an acute kidney injury prediction model across health systems
Cao J, Zhang X, Shahinian V, Yin H, Steffick D, Saran R, Crowley S, Mathis M, Nadkarni G, Heung M, Singh K. Generalizability of an acute kidney injury prediction model across health systems. Nature Machine Intelligence 2022, 4: 1121-1129. PMID: 38148789, PMCID: PMC10751025, DOI: 10.1038/s42256-022-00563-8.Peer-Reviewed Original ResearchAcute kidney injuryKidney injuryUS veteransAcute kidney injury modelHealth systemKidney injury modelAcademic hospital settingHospital cohortHospitalized patientsInjury prediction modelInjury modelHospital settingInjuryVeterans AffairsEffective interventionsHigher stageVeteransLower stageWorse discriminationRecent studiesMajor barrierPopulationFemalesSample sizeDecision tree model
2009
Intensity of renal replacement therapy in acute kidney injury: perspective from within the Acute Renal Failure Trial Network Study
Palevsky PM, O'Connor TZ, Chertow GM, Crowley ST, Zhang JH, Kellum JA, the US Department of Veterans Affairs/National Institutes of Health Acute Renal Failure Trial Network. Intensity of renal replacement therapy in acute kidney injury: perspective from within the Acute Renal Failure Trial Network Study. Critical Care 2009, 13: 310. PMID: 19678919, PMCID: PMC2750132, DOI: 10.1186/cc7901.Peer-Reviewed Original ResearchConceptsAcute kidney injuryRenal replacement therapyAcute Renal Failure Trial Network studyKidney injuryReplacement therapyStudy therapyRenal supportHealth Acute Renal Failure Trial Network studyVeterans Affairs/National InstitutesCause mortalityIll patientsKidney functionContinuous modalitiesStudy investigatorsOptimal doseClinical practiceTherapyVolume managementInjuryNational InstituteNetwork studiesHypotensionPatientsStudy resultsMortalityAcute Kidney Injury in the Intensive Care Unit
Crowley ST, Peixoto AJ. Acute Kidney Injury in the Intensive Care Unit. Clinics In Chest Medicine 2009, 30: 29-43. PMID: 19186279, DOI: 10.1016/j.ccm.2008.09.002.Peer-Reviewed Original ResearchConceptsAcute kidney injuryKidney injuryManagement of AKIPrognosis of AKITreatment of AKIIntensive insulin therapyUse of erythropoietinIntensive care unitBetter differential diagnosisInsulin therapyRenal functionDialysis modalityIll patientsCare unitDifferential diagnosisDialysis doseNovel biomarkersEarly identificationBioartificial kidneyDiagnosisInjuryModest changesPatientsPrognosisTherapy
2008
Intensity of Renal Support in Critically Ill Patients with Acute Kidney Injury
Palevsky P, Zhang J, O'Connor T, Chertow G, Crowley S, Choudhury D, Finkel K, Kellum J, Paganini E, Schein R, Smith M, Swanson K, Thompson B, Vijayan A, Watnick S, Star R, Peduzzi P. Intensity of Renal Support in Critically Ill Patients with Acute Kidney Injury. New England Journal Of Medicine 2008, 359: 7-20. PMID: 18492867, PMCID: PMC2574780, DOI: 10.1056/nejmoa0802639.Peer-Reviewed Original ResearchConceptsAcute kidney injuryRenal replacement therapyNonrenal organ failureContinuous venovenous hemodiafiltrationIntensive treatment strategiesKidney injuryIll patientsIntensive therapyIntermittent hemodialysisKidney functionOrgan failureRenal supportTreatment strategiesContinuous renal replacement therapyDay 60Intensive renal replacement therapyIntensive renal supportLow-efficiency dialysisCritically Ill PatientsPrimary end pointHemodialysis three timesRate of deathNonrenal organsBaseline characteristicsStable patientsLessons for Successful Study Enrollment from the Veterans Affairs/National Institutes of Health Acute Renal Failure Trial Network Study
Crowley ST, Chertow GM, Vitale J, O'Connor T, Zhang J, Schein RM, Choudhury D, Finkel K, Vijayan A, Paganini E, Palevsky PM, Group F. Lessons for Successful Study Enrollment from the Veterans Affairs/National Institutes of Health Acute Renal Failure Trial Network Study. Clinical Journal Of The American Society Of Nephrology 2008, 3: 955-961. PMID: 18385390, PMCID: PMC2440269, DOI: 10.2215/cjn.05621207.Peer-Reviewed Original ResearchMeSH KeywordsAcute Kidney InjuryBiasClinical Trials as TopicCritical IllnessHemodiafiltrationHumansInformed ConsentIntensive Care UnitsMulticenter Studies as TopicNational Institutes of Health (U.S.)Patient SelectionRandomized Controlled Trials as TopicRenal DialysisResearch DesignTreatment OutcomeUnited StatesUnited States Department of Veterans AffairsConceptsHealth Acute Renal Failure Trial Network studyAcute Renal Failure Trial Network studyVeterans Affairs/National InstitutesAcute kidney injuryEnrollment windowKidney injuryPhysician refusalPotential patientsChronic kidney diseaseRenal replacement therapyNational InstituteEnrollment efficiencyLoss of patientsEligible patientsUnderlying comorbiditiesIll patientsStudy enrollmentKidney diseaseReplacement therapyFuture trialsIntervention trialsClinical equipoiseChronic illnessClinical trialsInclusion criteria