2002
Axotomy does not up-regulate expression of sodium channel Nav1.8 in Purkinje cells
Black J, Dusart I, Sotelo C, Waxman S. Axotomy does not up-regulate expression of sodium channel Nav1.8 in Purkinje cells. Brain Research 2002, 101: 126-131. PMID: 12007840, DOI: 10.1016/s0169-328x(02)00200-0.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAxonsAxotomyCerebellumDisease Models, AnimalFemaleGanglia, SpinalGene Expression RegulationImmunohistochemistryMultiple SclerosisNAV1.8 Voltage-Gated Sodium ChannelNeurons, AfferentNeuropeptidesPurkinje CellsRatsRats, WistarRNA, MessengerSodium ChannelsUp-RegulationZebrafish ProteinsConceptsMultiple sclerosisPurkinje cellsSensory neuron-specific sodium channelsDorsal root ganglion neuronsAberrant expressionSodium channelsHuman multiple sclerosisPrimary sensory neuronsSodium channel Nav1.8Specific sodium channelsCerebellar Purkinje cellsGanglion neuronsSensory neuronsAxotomySurgical modelSodium channel transcriptsExperimental modelCerebellar functionChannel transcriptsNeuronsSitu hybridizationCellsExpressionNav1.8Sclerosis
1996
Orphan nuclear receptor RORα gene: isoform-specific spatiotemporal expression during postnatal development of brain
Sashihara S, Felts P, Waxman S, Matsui T. Orphan nuclear receptor RORα gene: isoform-specific spatiotemporal expression during postnatal development of brain. Brain Research 1996, 42: 109-117. PMID: 8915586, DOI: 10.1016/s0169-328x(96)00118-0.Peer-Reviewed Original ResearchConceptsROR alphaAlpha cDNAOrphan nuclear receptor ROR alphaSpatiotemporal expressionN-terminal regionIsoform-specific regulationAlpha expressionSpecific transcriptsCell typesHybridization signalsPurkinje cellsCDNAExpressionPostnatal developmentRelative levelsRegulationCellsAlphaPostnatal maturationTranscriptsOlfactory bulbRodent brainIsoformsBrain regionsMaturationExpression of mRNA for a sodium channel in subfamily 2 in spinal sensory neurons
Waxman S, Black J. Expression of mRNA for a sodium channel in subfamily 2 in spinal sensory neurons. Neurochemical Research 1996, 21: 395-401. PMID: 8734431, DOI: 10.1007/bf02527702.Peer-Reviewed Original ResearchConceptsDorsal root gangliaSpinal sensory neuronsSchwann cellsDRG neuronsSensory neuronsRat dorsal root gangliaSodium channelsΒ1 subunitExpression of mRNARoot gangliaSpinal cordSitu hybridization cytochemistryNeuronsΑ-subunitAntisense riboprobesBlot analysisType IMRNACellsExpressionHigh levelsGangliaRNA blot analysisHippocampusCord
1995
Na+ channel β1 subunit mRNA expression in developing rat central nervous system
Sashihara S, Oh Y, Black J, Waxman S. Na+ channel β1 subunit mRNA expression in developing rat central nervous system. Brain Research 1995, 34: 239-250. PMID: 8750827, DOI: 10.1016/0169-328x(95)00168-r.Peer-Reviewed Original ResearchConceptsGranule cell layerCell layerRat central nervous systemBeta 1Channel beta 1 subunitRexed's lamina IXDentate granule cellsPyramidal cell layerPostnatal day 2Beta 1 expressionSpecific neuronal populationsVentral-dorsal gradientCentral nervous systemSubunit mRNA expressionVoltage-dependent sodium channelsExternal granule cell layerInternal granule cell layerDorsal hornVentral hornLamina IXSpinal cordBeta 1 subunitAdult ratsIntensity of labelingGranule cellsExpression of sodium channel α- and β-subunits in the nervous system of themyelin-deficient rat
Felts P, Black J, Waxman S. Expression of sodium channel α- and β-subunits in the nervous system of themyelin-deficient rat. Brain Cell Biology 1995, 24: 654-666. PMID: 7500121, DOI: 10.1007/bf01179816.Peer-Reviewed Original ResearchConceptsSodium channel αMale littermatesSubtype-specific riboprobesDorsal root gangliaChannel αNormal male littermatesSodium channel subunitsUnaffected male littermatesDays of ageAdult expression patternRoot gangliaSpinal cordExpression patternsAdult ratsNervous systemUnaffected littermatesSodium channelsLittermatesPattern of expressionChannel subunitsRatsGreater expressionSitu hybridization techniqueUnaffected animalsPrevious reportsDifferential Na+ channel β1 subunit mRNA expression in stellate and flat astrocytes cultured from rat cortex and cerebellum: A combined in situ hybridization and immunocytochemistry study
Oh Y, Waxman S. Differential Na+ channel β1 subunit mRNA expression in stellate and flat astrocytes cultured from rat cortex and cerebellum: A combined in situ hybridization and immunocytochemistry study. Glia 1995, 13: 166-173. PMID: 7782102, DOI: 10.1002/glia.440130303.Peer-Reviewed Original ResearchConceptsGFAP-positive astrocytesRat brainChannel beta 1 subunit (Na beta 1) mRNAMRNA expressionBeta 1 mRNA expressionSubunit mRNA expressionBeta 1 mRNABeta 1 subunit mRNARat cortexGranule cellsStellate astrocytesRat astrocytesAstrocytesChannel mRNAImmunocytochemistry methodSubunit mRNAsImmunocytochemistry studiesCerebellumBrainMRNASitu hybridizationRecent studiesDifferential expressionExpressionCells
1994
In situ hybridization localization of the Na+ channel β1 subunit mRNA in rat CNS neurons
Oh Y, Sashihara S, Waxman S. In situ hybridization localization of the Na+ channel β1 subunit mRNA in rat CNS neurons. Neuroscience Letters 1994, 176: 119-122. PMID: 7970226, DOI: 10.1016/0304-3940(94)90885-0.Peer-Reviewed Original ResearchConceptsBeta 1 mRNASpinal cordGranule cellsChannel beta 1 subunit (Na beta 1) mRNABeta 1 mRNA expressionDentate granule cellsAdult rat hippocampusCA1 pyramidal cellsRat CNS neuronsBeta 1 subunit mRNASitu hybridization histochemistryCNS neuronsPyramidal cellsRat hippocampusSitu hybridization localizationChannel β1Gray matterHybridization histochemistryPurkinje cellsMRNA expressionSubunit mRNAsModerate expressionDifferent neuronsStrong expressionNeurons
1981
Impulse entrainment: Computer simulations and studies on the parallel fibers of the cerebellum
Kocsis J, Cummins K, Waxman S, Malenka R. Impulse entrainment: Computer simulations and studies on the parallel fibers of the cerebellum. Experimental Neurology 1981, 72: 628-637. PMID: 7238712, DOI: 10.1016/0014-4886(81)90011-x.Peer-Reviewed Original ResearchAction potential electrogenesis in mammalian central axons.
Kocsis J, Waxman S. Action potential electrogenesis in mammalian central axons. Advances In Neurology 1981, 31: 299-312. PMID: 6275668.Peer-Reviewed Original Research